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Gene: GSE1 |
Gene summary for GSE1 |
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Gene information | Species | Human | Gene symbol | GSE1 | Gene ID | 23199 |
Gene name | Gse1 coiled-coil protein | |
Gene Alias | CRHSP24 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q14687 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23199 | GSE1 | CA_HPV_1 | Human | Cervix | CC | 2.56e-02 | -1.09e-01 | 0.0264 |
23199 | GSE1 | CCI_1 | Human | Cervix | CC | 1.51e-04 | 6.79e-01 | 0.528 |
23199 | GSE1 | CCI_2 | Human | Cervix | CC | 7.09e-06 | 8.19e-01 | 0.5249 |
23199 | GSE1 | CCI_3 | Human | Cervix | CC | 1.40e-10 | 1.15e+00 | 0.516 |
23199 | GSE1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.06e-04 | 5.00e-01 | -0.1464 |
23199 | GSE1 | A015-C-203 | Human | Colorectum | FAP | 3.10e-22 | 8.60e-02 | -0.1294 |
23199 | GSE1 | A015-C-204 | Human | Colorectum | FAP | 1.53e-04 | 1.69e-01 | -0.0228 |
23199 | GSE1 | A014-C-040 | Human | Colorectum | FAP | 6.21e-05 | 3.05e-01 | -0.1184 |
23199 | GSE1 | A002-C-201 | Human | Colorectum | FAP | 1.73e-12 | 1.68e-01 | 0.0324 |
23199 | GSE1 | A002-C-203 | Human | Colorectum | FAP | 9.08e-04 | 8.87e-02 | 0.2786 |
23199 | GSE1 | A001-C-119 | Human | Colorectum | FAP | 2.15e-03 | 1.32e-02 | -0.1557 |
23199 | GSE1 | A001-C-108 | Human | Colorectum | FAP | 8.41e-11 | 3.64e-02 | -0.0272 |
23199 | GSE1 | A002-C-021 | Human | Colorectum | FAP | 3.43e-02 | 3.15e-01 | 0.1171 |
23199 | GSE1 | A002-C-205 | Human | Colorectum | FAP | 3.14e-17 | 2.58e-02 | -0.1236 |
23199 | GSE1 | A014-C-108 | Human | Colorectum | FAP | 1.36e-02 | 2.90e-01 | -0.124 |
23199 | GSE1 | A001-C-104 | Human | Colorectum | FAP | 1.41e-02 | 1.73e-01 | 0.0184 |
23199 | GSE1 | A015-C-006 | Human | Colorectum | FAP | 6.04e-09 | -8.70e-02 | -0.0994 |
23199 | GSE1 | A015-C-106 | Human | Colorectum | FAP | 1.66e-09 | 4.59e-02 | -0.0511 |
23199 | GSE1 | A002-C-114 | Human | Colorectum | FAP | 1.74e-14 | -1.57e-03 | -0.1561 |
23199 | GSE1 | A015-C-104 | Human | Colorectum | FAP | 5.13e-23 | 4.42e-02 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GSE1 | SNV | Missense_Mutation | rs368638789 | c.1496C>G | p.Ala499Gly | p.A499G | Q14687 | protein_coding | deleterious(0.04) | probably_damaging(0.929) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
GSE1 | SNV | Missense_Mutation | c.2942G>A | p.Gly981Glu | p.G981E | Q14687 | protein_coding | tolerated(0.95) | possibly_damaging(0.468) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GSE1 | SNV | Missense_Mutation | novel | c.299C>T | p.Pro100Leu | p.P100L | Q14687 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A2FG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | CR |
GSE1 | SNV | Missense_Mutation | novel | c.3220N>A | p.Ala1074Thr | p.A1074T | Q14687 | protein_coding | tolerated(0.58) | benign(0.236) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GSE1 | SNV | Missense_Mutation | novel | c.298C>A | p.Pro100Thr | p.P100T | Q14687 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSE1 | SNV | Missense_Mutation | rs142161580 | c.713N>T | p.Pro238Leu | p.P238L | Q14687 | protein_coding | deleterious(0.04) | possibly_damaging(0.725) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GSE1 | SNV | Missense_Mutation | c.3239N>G | p.Asn1080Ser | p.N1080S | Q14687 | protein_coding | deleterious(0.04) | benign(0.178) | TCGA-E9-A1NG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
GSE1 | SNV | Missense_Mutation | c.907N>A | p.Gly303Arg | p.G303R | Q14687 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
GSE1 | SNV | Missense_Mutation | novel | c.3506C>T | p.Ser1169Phe | p.S1169F | Q14687 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
GSE1 | deletion | Frame_Shift_Del | c.148_155delNNNNNNNN | p.Leu50ProfsTer87 | p.L50Pfs*87 | Q14687 | protein_coding | TCGA-AR-A1AH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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