![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GPRC5A |
Gene summary for GPRC5A |
![]() |
Gene information | Species | Human | Gene symbol | GPRC5A | Gene ID | 9052 |
Gene name | G protein-coupled receptor class C group 5 member A | |
Gene Alias | GPCR5A | |
Cytomap | 12p13.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q8NFJ5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9052 | GPRC5A | GSM4909282 | Human | Breast | IDC | 3.83e-18 | 7.07e-01 | -0.0288 |
9052 | GPRC5A | GSM4909290 | Human | Breast | IDC | 4.26e-03 | -2.61e-01 | 0.2096 |
9052 | GPRC5A | GSM4909293 | Human | Breast | IDC | 4.54e-03 | 3.01e-01 | 0.1581 |
9052 | GPRC5A | GSM4909296 | Human | Breast | IDC | 1.16e-02 | -1.20e-01 | 0.1524 |
9052 | GPRC5A | GSM4909304 | Human | Breast | IDC | 2.37e-02 | 2.18e-01 | 0.1636 |
9052 | GPRC5A | GSM4909311 | Human | Breast | IDC | 1.86e-12 | -1.35e-01 | 0.1534 |
9052 | GPRC5A | GSM4909312 | Human | Breast | IDC | 9.07e-08 | 3.78e-01 | 0.1552 |
9052 | GPRC5A | GSM4909313 | Human | Breast | IDC | 8.52e-06 | 5.09e-01 | 0.0391 |
9052 | GPRC5A | GSM4909317 | Human | Breast | IDC | 1.49e-03 | 3.99e-01 | 0.1355 |
9052 | GPRC5A | GSM4909319 | Human | Breast | IDC | 3.62e-14 | -2.20e-01 | 0.1563 |
9052 | GPRC5A | GSM4909321 | Human | Breast | IDC | 5.05e-09 | 3.57e-01 | 0.1559 |
9052 | GPRC5A | ctrl6 | Human | Breast | Precancer | 2.60e-32 | 1.18e+00 | -0.0061 |
9052 | GPRC5A | brca3 | Human | Breast | Precancer | 5.84e-04 | 3.43e-01 | -0.0263 |
9052 | GPRC5A | brca7 | Human | Breast | Precancer | 7.69e-03 | 8.28e-01 | -0.009 |
9052 | GPRC5A | brca10 | Human | Breast | Precancer | 6.70e-33 | 9.48e-01 | -0.0029 |
9052 | GPRC5A | M2 | Human | Breast | IDC | 9.03e-03 | -3.61e-01 | 0.21 |
9052 | GPRC5A | NCCBC11 | Human | Breast | DCIS | 5.79e-03 | -3.61e-01 | 0.1232 |
9052 | GPRC5A | NCCBC14 | Human | Breast | DCIS | 4.62e-06 | -8.15e-02 | 0.2021 |
9052 | GPRC5A | NCCBC3 | Human | Breast | DCIS | 1.71e-12 | -3.17e-01 | 0.1198 |
9052 | GPRC5A | NCCBC5 | Human | Breast | DCIS | 8.16e-05 | -1.87e-01 | 0.2046 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00336749 | Breast | Precancer | positive regulation of kinase activity | 42/1080 | 467/18723 | 2.94e-03 | 2.54e-02 | 42 |
GO:00513489 | Breast | Precancer | negative regulation of transferase activity | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
GO:005134814 | Breast | IDC | negative regulation of transferase activity | 39/1434 | 268/18723 | 7.89e-05 | 1.56e-03 | 39 |
GO:00459369 | Breast | IDC | negative regulation of phosphate metabolic process | 53/1434 | 441/18723 | 7.21e-04 | 8.79e-03 | 53 |
GO:00105639 | Breast | IDC | negative regulation of phosphorus metabolic process | 53/1434 | 442/18723 | 7.60e-04 | 9.25e-03 | 53 |
GO:00064699 | Breast | IDC | negative regulation of protein kinase activity | 27/1434 | 212/18723 | 6.30e-03 | 4.47e-02 | 27 |
GO:005134824 | Breast | DCIS | negative regulation of transferase activity | 39/1390 | 268/18723 | 4.02e-05 | 8.60e-04 | 39 |
GO:004593614 | Breast | DCIS | negative regulation of phosphate metabolic process | 53/1390 | 441/18723 | 3.48e-04 | 4.96e-03 | 53 |
GO:001056314 | Breast | DCIS | negative regulation of phosphorus metabolic process | 53/1390 | 442/18723 | 3.68e-04 | 5.18e-03 | 53 |
GO:000646913 | Breast | DCIS | negative regulation of protein kinase activity | 27/1390 | 212/18723 | 4.18e-03 | 3.30e-02 | 27 |
GO:00423269 | Breast | DCIS | negative regulation of phosphorylation | 43/1390 | 385/18723 | 4.78e-03 | 3.62e-02 | 43 |
GO:00019339 | Breast | DCIS | negative regulation of protein phosphorylation | 39/1390 | 342/18723 | 4.94e-03 | 3.71e-02 | 39 |
GO:00336738 | Breast | DCIS | negative regulation of kinase activity | 29/1390 | 237/18723 | 5.44e-03 | 3.99e-02 | 29 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPRC5A | SNV | Missense_Mutation | rs745823691 | c.1007N>A | p.Ser336Tyr | p.S336Y | Q8NFJ5 | protein_coding | tolerated(0.44) | probably_damaging(0.997) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GPRC5A | SNV | Missense_Mutation | novel | c.764T>G | p.Val255Gly | p.V255G | Q8NFJ5 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
GPRC5A | SNV | Missense_Mutation | novel | c.514N>T | p.Arg172Cys | p.R172C | Q8NFJ5 | protein_coding | deleterious(0.01) | possibly_damaging(0.745) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPRC5A | SNV | Missense_Mutation | c.313T>G | p.Phe105Val | p.F105V | Q8NFJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPRC5A | SNV | Missense_Mutation | rs775011273 | c.88N>A | p.Val30Ile | p.V30I | Q8NFJ5 | protein_coding | tolerated(0.14) | benign(0.03) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
GPRC5A | SNV | Missense_Mutation | rs775011273 | c.88N>A | p.Val30Ile | p.V30I | Q8NFJ5 | protein_coding | tolerated(0.14) | benign(0.03) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
GPRC5A | SNV | Missense_Mutation | c.962C>T | p.Ser321Phe | p.S321F | Q8NFJ5 | protein_coding | deleterious(0.01) | benign(0.384) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GPRC5A | SNV | Missense_Mutation | novel | c.250N>C | p.Ala84Pro | p.A84P | Q8NFJ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GPRC5A | SNV | Missense_Mutation | c.643N>T | p.Leu215Phe | p.L215F | Q8NFJ5 | protein_coding | tolerated(0.2) | benign(0.027) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
GPRC5A | SNV | Missense_Mutation | novel | c.752C>T | p.Ala251Val | p.A251V | Q8NFJ5 | protein_coding | tolerated(0.38) | benign(0.069) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |