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Gene: GMCL1 |
Gene summary for GMCL1 |
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Gene information | Species | Human | Gene symbol | GMCL1 | Gene ID | 64395 |
Gene name | germ cell-less 1, spermatogenesis associated | |
Gene Alias | BTBD13 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q53SE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64395 | GMCL1 | LZE2T | Human | Esophagus | ESCC | 2.56e-03 | 5.47e-01 | 0.082 |
64395 | GMCL1 | LZE4T | Human | Esophagus | ESCC | 5.17e-11 | 4.22e-01 | 0.0811 |
64395 | GMCL1 | LZE5T | Human | Esophagus | ESCC | 9.54e-04 | 3.55e-01 | 0.0514 |
64395 | GMCL1 | LZE7T | Human | Esophagus | ESCC | 1.61e-13 | 7.97e-01 | 0.0667 |
64395 | GMCL1 | LZE8T | Human | Esophagus | ESCC | 4.55e-07 | 3.16e-01 | 0.067 |
64395 | GMCL1 | LZE24T | Human | Esophagus | ESCC | 2.79e-12 | 4.52e-01 | 0.0596 |
64395 | GMCL1 | LZE21T | Human | Esophagus | ESCC | 7.44e-03 | 2.39e-01 | 0.0655 |
64395 | GMCL1 | P1T-E | Human | Esophagus | ESCC | 8.16e-07 | 4.34e-01 | 0.0875 |
64395 | GMCL1 | P2T-E | Human | Esophagus | ESCC | 9.30e-39 | 7.65e-01 | 0.1177 |
64395 | GMCL1 | P4T-E | Human | Esophagus | ESCC | 3.48e-23 | 4.68e-01 | 0.1323 |
64395 | GMCL1 | P5T-E | Human | Esophagus | ESCC | 2.82e-07 | 2.13e-01 | 0.1327 |
64395 | GMCL1 | P8T-E | Human | Esophagus | ESCC | 3.42e-13 | 3.12e-01 | 0.0889 |
64395 | GMCL1 | P9T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.72e-01 | 0.1131 |
64395 | GMCL1 | P10T-E | Human | Esophagus | ESCC | 8.47e-27 | 6.26e-01 | 0.116 |
64395 | GMCL1 | P11T-E | Human | Esophagus | ESCC | 4.88e-13 | 4.66e-01 | 0.1426 |
64395 | GMCL1 | P12T-E | Human | Esophagus | ESCC | 1.13e-36 | 8.30e-01 | 0.1122 |
64395 | GMCL1 | P15T-E | Human | Esophagus | ESCC | 1.41e-28 | 5.65e-01 | 0.1149 |
64395 | GMCL1 | P16T-E | Human | Esophagus | ESCC | 4.57e-24 | 6.72e-01 | 0.1153 |
64395 | GMCL1 | P19T-E | Human | Esophagus | ESCC | 3.87e-06 | 5.37e-01 | 0.1662 |
64395 | GMCL1 | P20T-E | Human | Esophagus | ESCC | 1.16e-19 | 5.01e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GMCL1 | SNV | Missense_Mutation | rs560427399 | c.644N>T | p.Gly215Val | p.G215V | Q96IK5 | protein_coding | tolerated(0.14) | benign(0.309) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
GMCL1 | SNV | Missense_Mutation | novel | c.143G>C | p.Gly48Ala | p.G48A | Q96IK5 | protein_coding | deleterious(0.01) | benign(0.235) | TCGA-E2-A15R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
GMCL1 | SNV | Missense_Mutation | c.1085N>T | p.Ser362Phe | p.S362F | Q96IK5 | protein_coding | deleterious(0) | benign(0.281) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GMCL1 | SNV | Missense_Mutation | c.39A>T | p.Arg13Ser | p.R13S | Q96IK5 | protein_coding | tolerated(0.61) | benign(0) | TCGA-JW-A5VH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
GMCL1 | SNV | Missense_Mutation | c.1090N>C | p.Tyr364His | p.Y364H | Q96IK5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GMCL1 | SNV | Missense_Mutation | novel | c.424N>A | p.Glu142Lys | p.E142K | Q96IK5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GMCL1 | SNV | Missense_Mutation | novel | c.376N>G | p.Leu126Val | p.L126V | Q96IK5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GMCL1 | SNV | Missense_Mutation | novel | c.920N>A | p.Ser307Tyr | p.S307Y | Q96IK5 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GMCL1 | insertion | Frame_Shift_Ins | novel | c.1541dupA | p.Asn515GlufsTer22 | p.N515Efs*22 | Q96IK5 | protein_coding | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
GMCL1 | SNV | Missense_Mutation | c.1297N>T | p.Arg433Cys | p.R433C | Q96IK5 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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