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Gene: FLT1 |
Gene summary for FLT1 |
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Gene information | Species | Human | Gene symbol | FLT1 | Gene ID | 2321 |
Gene name | fms related receptor tyrosine kinase 1 | |
Gene Alias | FLT | |
Cytomap | 13q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P17948 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2321 | FLT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.67e-04 | 1.32e-01 | 0.0155 |
2321 | FLT1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.72e-07 | 3.21e-01 | -0.1808 |
2321 | FLT1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.70e-16 | 6.30e-01 | -0.0811 |
2321 | FLT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.12e-09 | 2.59e-01 | -0.1088 |
2321 | FLT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.22e-04 | 1.62e-01 | -0.1954 |
2321 | FLT1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.26e-04 | 2.24e-01 | -0.1207 |
2321 | FLT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.02e-04 | 2.47e-01 | -0.1526 |
2321 | FLT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.19e-14 | 2.72e-01 | -0.1464 |
2321 | FLT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.05e-06 | 1.53e-01 | -0.1001 |
2321 | FLT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.18e-07 | 2.26e-01 | -0.059 |
2321 | FLT1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.77e-05 | 3.61e-01 | 0.0451 |
2321 | FLT1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.47e-02 | 2.47e-01 | 0.0131 |
2321 | FLT1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.89e-09 | 4.93e-01 | 0.0112 |
2321 | FLT1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.11e-05 | 2.54e-01 | 0.0588 |
2321 | FLT1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.30e-41 | 7.06e-01 | 0.294 |
2321 | FLT1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.69e-08 | 7.11e-01 | 0.3487 |
2321 | FLT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.44e-12 | 2.29e-01 | 0.3005 |
2321 | FLT1 | HCC1 | Human | Liver | HCC | 1.08e-08 | 4.46e+00 | 0.5336 |
2321 | FLT1 | HCC2 | Human | Liver | HCC | 1.66e-14 | 1.27e+00 | 0.5341 |
2321 | FLT1 | HCC5 | Human | Liver | HCC | 3.89e-10 | 1.16e+00 | 0.4932 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0071900 | Colorectum | AD | regulation of protein serine/threonine kinase activity | 98/3918 | 359/18723 | 2.18e-03 | 1.73e-02 | 98 |
GO:0071902 | Colorectum | AD | positive regulation of protein serine/threonine kinase activity | 58/3918 | 200/18723 | 4.09e-03 | 2.84e-02 | 58 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:00467771 | Colorectum | SER | protein autophosphorylation | 60/2897 | 227/18723 | 1.36e-05 | 4.25e-04 | 60 |
GO:00336741 | Colorectum | SER | positive regulation of kinase activity | 95/2897 | 467/18723 | 2.62e-03 | 2.41e-02 | 95 |
GO:00480171 | Colorectum | SER | inositol lipid-mediated signaling | 42/2897 | 182/18723 | 4.36e-03 | 3.49e-02 | 42 |
GO:00458601 | Colorectum | SER | positive regulation of protein kinase activity | 79/2897 | 386/18723 | 4.85e-03 | 3.79e-02 | 79 |
GO:00480151 | Colorectum | SER | phosphatidylinositol-mediated signaling | 41/2897 | 178/18723 | 4.97e-03 | 3.86e-02 | 41 |
GO:00719001 | Colorectum | SER | regulation of protein serine/threonine kinase activity | 74/2897 | 359/18723 | 5.22e-03 | 3.96e-02 | 74 |
GO:00336742 | Colorectum | MSS | positive regulation of kinase activity | 122/3467 | 467/18723 | 2.50e-05 | 5.21e-04 | 122 |
GO:00458602 | Colorectum | MSS | positive regulation of protein kinase activity | 102/3467 | 386/18723 | 6.93e-05 | 1.20e-03 | 102 |
GO:00719002 | Colorectum | MSS | regulation of protein serine/threonine kinase activity | 93/3467 | 359/18723 | 2.98e-04 | 3.91e-03 | 93 |
GO:00467772 | Colorectum | MSS | protein autophosphorylation | 63/3467 | 227/18723 | 3.96e-04 | 4.91e-03 | 63 |
GO:00506731 | Colorectum | MSS | epithelial cell proliferation | 108/3467 | 437/18723 | 6.76e-04 | 7.30e-03 | 108 |
GO:00719021 | Colorectum | MSS | positive regulation of protein serine/threonine kinase activity | 55/3467 | 200/18723 | 1.12e-03 | 1.11e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa040662 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa040663 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa040664 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa040154 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa040665 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0406622 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
hsa0451051 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0406632 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Breast | ADJ |
PGF | FLT1 | PGF_VEGFR1 | VEGF | Breast | ADJ |
VEGFA | FLT1_KDR | VEGFA_VEGFR1R2 | VEGF | Breast | ADJ |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Breast | DCIS |
VEGFB | FLT1 | VEGFB_VEGFR1 | VEGF | Breast | DCIS |
PGF | FLT1 | PGF_VEGFR1 | VEGF | Breast | DCIS |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Breast | Healthy |
VEGFB | FLT1 | VEGFB_VEGFR1 | VEGF | Breast | Healthy |
PGF | FLT1 | PGF_VEGFR1 | VEGF | Breast | Healthy |
VEGFA | FLT1_KDR | VEGFA_VEGFR1R2 | VEGF | Breast | Healthy |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Breast | IDC |
PGF | FLT1 | PGF_VEGFR1 | VEGF | Breast | IDC |
VEGFA | FLT1_KDR | VEGFA_VEGFR1R2 | VEGF | Breast | IDC |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Breast | Precancer |
PGF | FLT1 | PGF_VEGFR1 | VEGF | Breast | Precancer |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Cervix | ADJ |
VEGFB | FLT1 | VEGFB_VEGFR1 | VEGF | Cervix | ADJ |
VEGFA | FLT1_KDR | VEGFA_VEGFR1R2 | VEGF | Cervix | ADJ |
VEGFA | FLT1 | VEGFA_VEGFR1 | VEGF | Cervix | CC |
VEGFB | FLT1 | VEGFB_VEGFR1 | VEGF | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLT1 | SNV | Missense_Mutation | c.1596N>G | p.Ile532Met | p.I532M | P17948 | protein_coding | tolerated(0.98) | possibly_damaging(0.882) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FLT1 | SNV | Missense_Mutation | c.3929A>G | p.Asp1310Gly | p.D1310G | P17948 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FLT1 | SNV | Missense_Mutation | novel | c.1982C>A | p.Pro661Gln | p.P661Q | P17948 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
FLT1 | SNV | Missense_Mutation | c.3040N>C | p.Ser1014Pro | p.S1014P | P17948 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AR-A1AQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FLT1 | SNV | Missense_Mutation | c.876C>G | p.Phe292Leu | p.F292L | P17948 | protein_coding | tolerated(0.41) | probably_damaging(0.999) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FLT1 | SNV | Missense_Mutation | c.277N>T | p.Thr93Ser | p.T93S | P17948 | protein_coding | tolerated(0.28) | probably_damaging(0.978) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FLT1 | insertion | Frame_Shift_Ins | novel | c.1979_1980insCAGGTGTTCCAAGTTCT | p.Pro661ArgfsTer26 | p.P661Rfs*26 | P17948 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
FLT1 | SNV | Missense_Mutation | rs759739030 | c.3914G>A | p.Arg1305His | p.R1305H | P17948 | protein_coding | tolerated(0.2) | possibly_damaging(0.613) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FLT1 | SNV | Missense_Mutation | c.1596C>G | p.Ile532Met | p.I532M | P17948 | protein_coding | tolerated(0.98) | possibly_damaging(0.882) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FLT1 | SNV | Missense_Mutation | rs373801409 | c.406G>A | p.Val136Ile | p.V136I | P17948 | protein_coding | tolerated(0.91) | benign(0.006) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | inhibitor | VANDETANIB | VANDETANIB | |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | TABERMINOGENE VADENOVEC | |||
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | NINTEDANIB | NINTEDANIB | ||
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | VANDETANIB | VANDETANIB | ||
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | inhibitor | 178102585 | DOVITINIB | |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | inhibitor | CHEMBL522892 | DOVITINIB | |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | inhibitor | AXITINIB | AXITINIB | |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | inhibitor | CHEMBL3544927 | L-21649 | |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | inhibitor | 363894211 | PEXMETINIB | |
2321 | FLT1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, TYROSINE KINASE | PAZOPANIB | PAZOPANIB |
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