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Gene: FAM81B |
Gene summary for FAM81B |
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Gene information | Species | Human | Gene symbol | FAM81B | Gene ID | 153643 |
Gene name | family with sequence similarity 81 member B | |
Gene Alias | FAM81B | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96LP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153643 | FAM81B | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 5.90e-01 | -0.0186 |
153643 | FAM81B | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 4.97e-01 | -0.0296 |
153643 | FAM81B | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 5.54e-03 | 5.18e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM81B | SNV | Missense_Mutation | novel | c.857N>A | p.Gly286Glu | p.G286E | Q96LP2 | protein_coding | tolerated(0.07) | possibly_damaging(0.883) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | rs746583579 | c.866N>A | p.Arg289His | p.R289H | Q96LP2 | protein_coding | tolerated(0.94) | benign(0.005) | TCGA-AR-A24P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | rs756787447 | c.1102N>G | p.Gln368Glu | p.Q368E | Q96LP2 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-B6-A40B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | novel | c.879C>A | p.Asn293Lys | p.N293K | Q96LP2 | protein_coding | tolerated(0.25) | benign(0.381) | TCGA-BH-A8FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | c.373N>G | p.Ile125Val | p.I125V | Q96LP2 | protein_coding | tolerated(0.16) | benign(0.071) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
FAM81B | SNV | Missense_Mutation | c.166G>C | p.Glu56Gln | p.E56Q | Q96LP2 | protein_coding | tolerated_low_confidence(0.08) | benign(0.073) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
FAM81B | SNV | Missense_Mutation | c.122N>T | p.Ser41Leu | p.S41L | Q96LP2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.007) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM81B | SNV | Missense_Mutation | rs148381850 | c.871N>A | p.Glu291Lys | p.E291K | Q96LP2 | protein_coding | tolerated(0.05) | benign(0.069) | TCGA-VS-A957-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM81B | SNV | Missense_Mutation | c.432N>T | p.Gln144His | p.Q144H | Q96LP2 | protein_coding | tolerated(0.15) | benign(0.222) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM81B | SNV | Missense_Mutation | novel | c.607A>T | p.Asn203Tyr | p.N203Y | Q96LP2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A6-6650-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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