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Gene: FAM134A |
Gene summary for FAM134A |
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Gene information | Species | Human | Gene symbol | FAM134A | Gene ID | 79137 |
Gene name | reticulophagy regulator family member 2 | |
Gene Alias | C2orf17 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B3KR51 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79137 | FAM134A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.17e-24 | 4.04e-01 | 0.294 |
79137 | FAM134A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.91e-08 | 7.22e-01 | 0.3487 |
79137 | FAM134A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.91e-05 | 1.69e-01 | 0.281 |
79137 | FAM134A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.59e-37 | 6.32e-01 | 0.3859 |
79137 | FAM134A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.35e-11 | 3.99e-01 | 0.2585 |
79137 | FAM134A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.80e-25 | 4.63e-01 | 0.3005 |
79137 | FAM134A | P1T-E | Human | Esophagus | ESCC | 2.58e-08 | 6.61e-01 | 0.0875 |
79137 | FAM134A | P2T-E | Human | Esophagus | ESCC | 1.88e-27 | 5.77e-01 | 0.1177 |
79137 | FAM134A | P4T-E | Human | Esophagus | ESCC | 1.92e-11 | 2.31e-01 | 0.1323 |
79137 | FAM134A | P5T-E | Human | Esophagus | ESCC | 3.63e-11 | 2.58e-01 | 0.1327 |
79137 | FAM134A | P8T-E | Human | Esophagus | ESCC | 5.90e-13 | 1.98e-01 | 0.0889 |
79137 | FAM134A | P9T-E | Human | Esophagus | ESCC | 4.85e-18 | 1.87e-01 | 0.1131 |
79137 | FAM134A | P10T-E | Human | Esophagus | ESCC | 1.02e-14 | 2.04e-01 | 0.116 |
79137 | FAM134A | P11T-E | Human | Esophagus | ESCC | 3.49e-12 | 5.26e-01 | 0.1426 |
79137 | FAM134A | P12T-E | Human | Esophagus | ESCC | 1.86e-24 | 3.05e-01 | 0.1122 |
79137 | FAM134A | P15T-E | Human | Esophagus | ESCC | 1.14e-31 | 5.63e-01 | 0.1149 |
79137 | FAM134A | P16T-E | Human | Esophagus | ESCC | 8.98e-22 | 2.86e-01 | 0.1153 |
79137 | FAM134A | P17T-E | Human | Esophagus | ESCC | 1.12e-02 | 4.26e-02 | 0.1278 |
79137 | FAM134A | P19T-E | Human | Esophagus | ESCC | 1.08e-02 | 1.99e-01 | 0.1662 |
79137 | FAM134A | P20T-E | Human | Esophagus | ESCC | 1.68e-16 | 3.69e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM134A | SNV | Missense_Mutation | rs368573403 | c.341N>G | p.Tyr114Cys | p.Y114C | Q8NC44 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-AC-A3YJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
FAM134A | SNV | Missense_Mutation | c.1246N>T | p.Gly416Trp | p.G416W | Q8NC44 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
FAM134A | SNV | Missense_Mutation | c.1501N>C | p.Glu501Gln | p.E501Q | Q8NC44 | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM134A | SNV | Missense_Mutation | rs199754357 | c.1339G>A | p.Gly447Ser | p.G447S | Q8NC44 | protein_coding | tolerated(0.95) | benign(0) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM134A | SNV | Missense_Mutation | c.1322N>A | p.Gly441Asp | p.G441D | Q8NC44 | protein_coding | tolerated(0.86) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM134A | deletion | Frame_Shift_Del | c.1288delN | p.Val430TrpfsTer4 | p.V430Wfs*4 | Q8NC44 | protein_coding | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
FAM134A | SNV | Missense_Mutation | novel | c.1503N>T | p.Glu501Asp | p.E501D | Q8NC44 | protein_coding | tolerated(0.22) | benign(0.057) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM134A | SNV | Missense_Mutation | novel | c.405G>T | p.Glu135Asp | p.E135D | Q8NC44 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM134A | SNV | Missense_Mutation | rs760137264 | c.787N>T | p.Arg263Cys | p.R263C | Q8NC44 | protein_coding | deleterious(0.01) | possibly_damaging(0.676) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM134A | SNV | Missense_Mutation | novel | c.1586N>T | p.Ser529Phe | p.S529F | Q8NC44 | protein_coding | tolerated_low_confidence(0.12) | benign(0.181) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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