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Gene: FAM118A |
Gene summary for FAM118A |
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Gene information | Species | Human | Gene symbol | FAM118A | Gene ID | 55007 |
Gene name | family with sequence similarity 118 member A | |
Gene Alias | C22orf8 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R4V3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55007 | FAM118A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.03e-02 | 9.13e-02 | 0.0155 |
55007 | FAM118A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.01e-03 | 4.24e-01 | -0.059 |
55007 | FAM118A | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.22e-03 | 3.50e-01 | 0.0338 |
55007 | FAM118A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.97e-36 | 1.39e+00 | 0.281 |
55007 | FAM118A | A015-C-203 | Human | Colorectum | FAP | 4.59e-09 | -1.80e-01 | -0.1294 |
55007 | FAM118A | A002-C-201 | Human | Colorectum | FAP | 1.03e-02 | -1.29e-01 | 0.0324 |
55007 | FAM118A | A001-C-108 | Human | Colorectum | FAP | 2.10e-02 | 2.73e-02 | -0.0272 |
55007 | FAM118A | A002-C-205 | Human | Colorectum | FAP | 3.98e-07 | -8.24e-02 | -0.1236 |
55007 | FAM118A | A015-C-006 | Human | Colorectum | FAP | 9.63e-03 | -1.49e-01 | -0.0994 |
55007 | FAM118A | A002-C-114 | Human | Colorectum | FAP | 5.20e-04 | -1.04e-01 | -0.1561 |
55007 | FAM118A | A015-C-104 | Human | Colorectum | FAP | 2.27e-09 | -2.16e-01 | -0.1899 |
55007 | FAM118A | A001-C-014 | Human | Colorectum | FAP | 6.76e-03 | -2.87e-02 | 0.0135 |
55007 | FAM118A | A002-C-016 | Human | Colorectum | FAP | 1.72e-07 | -1.17e-01 | 0.0521 |
55007 | FAM118A | A015-C-002 | Human | Colorectum | FAP | 1.11e-02 | -1.04e-01 | -0.0763 |
55007 | FAM118A | A002-C-116 | Human | Colorectum | FAP | 1.61e-14 | -1.90e-01 | -0.0452 |
55007 | FAM118A | A014-C-008 | Human | Colorectum | FAP | 2.02e-03 | -5.92e-02 | -0.191 |
55007 | FAM118A | A018-E-020 | Human | Colorectum | FAP | 6.87e-06 | -6.25e-02 | -0.2034 |
55007 | FAM118A | F034 | Human | Colorectum | FAP | 4.25e-05 | -6.68e-02 | -0.0665 |
55007 | FAM118A | CRC-1-8810 | Human | Colorectum | CRC | 1.17e-03 | -3.02e-01 | 0.6257 |
55007 | FAM118A | LZE2T | Human | Esophagus | ESCC | 3.79e-06 | 8.49e-01 | 0.082 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM118A | insertion | Frame_Shift_Ins | novel | c.821_822insC | p.Gln275SerfsTer19 | p.Q275Sfs*19 | Q9NWS6 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAM118A | insertion | Nonsense_Mutation | novel | c.822_823insGCCTGGCCGTGGTATTGAATTTCCACA | p.His274_Gln275insAlaTrpProTrpTyrTerIleSerThr | p.H274_Q275insAWPWY*IST | Q9NWS6 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAM118A | SNV | Missense_Mutation | rs768565583 | c.302G>A | p.Arg101His | p.R101H | Q9NWS6 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
FAM118A | SNV | Missense_Mutation | c.739N>A | p.Phe247Ile | p.F247I | Q9NWS6 | protein_coding | tolerated(0.15) | possibly_damaging(0.833) | TCGA-AA-3494-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PR | |
FAM118A | SNV | Missense_Mutation | c.749N>G | p.Ser250Cys | p.S250C | Q9NWS6 | protein_coding | deleterious(0.02) | probably_damaging(0.923) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM118A | SNV | Missense_Mutation | c.755C>A | p.Pro252Gln | p.P252Q | Q9NWS6 | protein_coding | tolerated(0.25) | benign(0.048) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM118A | deletion | Frame_Shift_Del | c.1035delA | p.Lys345AsnfsTer23 | p.K345Nfs*23 | Q9NWS6 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
FAM118A | insertion | Frame_Shift_Ins | novel | c.1028_1029insA | p.Arg346ThrfsTer7 | p.R346Tfs*7 | Q9NWS6 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
FAM118A | SNV | Missense_Mutation | novel | c.740N>G | p.Phe247Cys | p.F247C | Q9NWS6 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM118A | SNV | Missense_Mutation | novel | c.956N>T | p.Ser319Ile | p.S319I | Q9NWS6 | protein_coding | deleterious_low_confidence(0) | benign(0.386) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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