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Gene: ENDOD1 |
Gene summary for ENDOD1 |
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Gene information | Species | Human | Gene symbol | ENDOD1 | Gene ID | 23052 |
Gene name | endonuclease domain containing 1 | |
Gene Alias | ENDOD1 | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O94919 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23052 | ENDOD1 | LZE4T | Human | Esophagus | ESCC | 3.36e-08 | 2.44e-01 | 0.0811 |
23052 | ENDOD1 | P1T-E | Human | Esophagus | ESCC | 1.09e-02 | 1.40e-01 | 0.0875 |
23052 | ENDOD1 | P2T-E | Human | Esophagus | ESCC | 1.26e-10 | 1.28e-01 | 0.1177 |
23052 | ENDOD1 | P4T-E | Human | Esophagus | ESCC | 2.69e-37 | 8.68e-01 | 0.1323 |
23052 | ENDOD1 | P5T-E | Human | Esophagus | ESCC | 1.46e-16 | 3.40e-01 | 0.1327 |
23052 | ENDOD1 | P8T-E | Human | Esophagus | ESCC | 2.22e-22 | 4.68e-01 | 0.0889 |
23052 | ENDOD1 | P9T-E | Human | Esophagus | ESCC | 9.33e-10 | 1.51e-01 | 0.1131 |
23052 | ENDOD1 | P10T-E | Human | Esophagus | ESCC | 1.44e-13 | 1.88e-01 | 0.116 |
23052 | ENDOD1 | P11T-E | Human | Esophagus | ESCC | 3.60e-21 | 9.17e-01 | 0.1426 |
23052 | ENDOD1 | P12T-E | Human | Esophagus | ESCC | 1.51e-30 | 5.04e-01 | 0.1122 |
23052 | ENDOD1 | P15T-E | Human | Esophagus | ESCC | 4.44e-05 | 8.09e-02 | 0.1149 |
23052 | ENDOD1 | P16T-E | Human | Esophagus | ESCC | 3.74e-15 | 2.48e-01 | 0.1153 |
23052 | ENDOD1 | P17T-E | Human | Esophagus | ESCC | 7.88e-07 | 5.39e-01 | 0.1278 |
23052 | ENDOD1 | P19T-E | Human | Esophagus | ESCC | 1.01e-14 | 9.75e-01 | 0.1662 |
23052 | ENDOD1 | P20T-E | Human | Esophagus | ESCC | 1.64e-06 | 2.42e-01 | 0.1124 |
23052 | ENDOD1 | P21T-E | Human | Esophagus | ESCC | 5.36e-24 | 4.85e-01 | 0.1617 |
23052 | ENDOD1 | P22T-E | Human | Esophagus | ESCC | 1.28e-08 | 1.27e-01 | 0.1236 |
23052 | ENDOD1 | P23T-E | Human | Esophagus | ESCC | 5.04e-13 | 2.74e-01 | 0.108 |
23052 | ENDOD1 | P24T-E | Human | Esophagus | ESCC | 6.29e-18 | 4.19e-01 | 0.1287 |
23052 | ENDOD1 | P26T-E | Human | Esophagus | ESCC | 1.08e-14 | 2.46e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00903051 | Oral cavity | LP | nucleic acid phosphodiester bond hydrolysis | 92/4623 | 261/18723 | 8.07e-05 | 1.04e-03 | 92 |
GO:00903054 | Skin | cSCC | nucleic acid phosphodiester bond hydrolysis | 97/4864 | 261/18723 | 4.08e-05 | 4.34e-04 | 97 |
GO:00903055 | Thyroid | PTC | nucleic acid phosphodiester bond hydrolysis | 105/5968 | 261/18723 | 2.53e-03 | 1.31e-02 | 105 |
GO:009030511 | Thyroid | ATC | nucleic acid phosphodiester bond hydrolysis | 107/6293 | 261/18723 | 7.21e-03 | 2.84e-02 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENDOD1 | SNV | Missense_Mutation | novel | c.1188N>A | p.Ser396Arg | p.S396R | O94919 | protein_coding | deleterious(0) | possibly_damaging(0.795) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ENDOD1 | SNV | Missense_Mutation | novel | c.184N>A | p.Ala62Thr | p.A62T | O94919 | protein_coding | tolerated(0.5) | benign(0.138) | TCGA-LD-A9QF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
ENDOD1 | insertion | In_Frame_Ins | novel | c.914_915insGGGGACTTCTCCAGAGTCTGGGCAGGATGA | p.Leu305_Ser306insGlyThrSerProGluSerGlyGlnAspAsp | p.L305_S306insGTSPESGQDD | O94919 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ENDOD1 | insertion | Frame_Shift_Ins | novel | c.1223_1224insGG | p.Ile409AlafsTer13 | p.I409Afs*13 | O94919 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ENDOD1 | insertion | Nonsense_Mutation | novel | c.1225_1226insGTCCCTGAGTTTGTTTGGCTGGCAGCC | p.Ile409delinsSerProTerValCysLeuAlaGlySerLeu | p.I409delinsSP*VCLAGSL | O94919 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ENDOD1 | SNV | Missense_Mutation | novel | c.478N>G | p.Leu160Val | p.L160V | O94919 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENDOD1 | SNV | Missense_Mutation | c.1152N>G | p.Ile384Met | p.I384M | O94919 | protein_coding | tolerated(0.18) | benign(0.1) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ENDOD1 | SNV | Missense_Mutation | novel | c.1055C>T | p.Ala352Val | p.A352V | O94919 | protein_coding | tolerated(0.24) | benign(0.107) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ENDOD1 | SNV | Missense_Mutation | novel | c.1385N>T | p.Thr462Ile | p.T462I | O94919 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENDOD1 | SNV | Missense_Mutation | novel | c.841N>C | p.Lys281Gln | p.K281Q | O94919 | protein_coding | tolerated(0.15) | probably_damaging(0.939) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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