Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DUOXA1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DUOXA1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DUOXA1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DUOXA1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200037718 | Esophagus | ESCC | regulation of reactive oxygen species metabolic process | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:00103101 | Esophagus | ESCC | regulation of hydrogen peroxide metabolic process | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:200037918 | Esophagus | ESCC | positive regulation of reactive oxygen species metabolic process | 45/8552 | 76/18723 | 1.21e-02 | 4.04e-02 | 45 |
GO:200037716 | Oral cavity | OSCC | regulation of reactive oxygen species metabolic process | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:007259316 | Oral cavity | OSCC | reactive oxygen species metabolic process | 122/7305 | 239/18723 | 9.73e-05 | 7.34e-04 | 122 |
GO:200037916 | Oral cavity | OSCC | positive regulation of reactive oxygen species metabolic process | 43/7305 | 76/18723 | 1.41e-03 | 6.84e-03 | 43 |
GO:00065756 | Oral cavity | OSCC | cellular modified amino acid metabolic process | 91/7305 | 188/18723 | 5.33e-03 | 2.07e-02 | 91 |
GO:200037717 | Oral cavity | LP | regulation of reactive oxygen species metabolic process | 67/4623 | 157/18723 | 5.54e-07 | 1.51e-05 | 67 |
GO:200037917 | Oral cavity | LP | positive regulation of reactive oxygen species metabolic process | 35/4623 | 76/18723 | 4.04e-05 | 5.90e-04 | 35 |
GO:007259317 | Oral cavity | LP | reactive oxygen species metabolic process | 85/4623 | 239/18723 | 1.04e-04 | 1.26e-03 | 85 |
GO:000657512 | Oral cavity | LP | cellular modified amino acid metabolic process | 64/4623 | 188/18723 | 2.43e-03 | 1.73e-02 | 64 |
GO:00065758 | Skin | cSCC | cellular modified amino acid metabolic process | 73/4864 | 188/18723 | 7.11e-05 | 6.85e-04 | 73 |
GO:200037719 | Skin | cSCC | regulation of reactive oxygen species metabolic process | 58/4864 | 157/18723 | 1.55e-03 | 9.60e-03 | 58 |
GO:007259319 | Skin | cSCC | reactive oxygen species metabolic process | 81/4864 | 239/18723 | 3.80e-03 | 2.03e-02 | 81 |
GO:00323502 | Skin | cSCC | regulation of hormone metabolic process | 16/4864 | 35/18723 | 9.09e-03 | 4.16e-02 | 16 |
GO:0072593110 | Thyroid | PTC | reactive oxygen species metabolic process | 108/5968 | 239/18723 | 1.02e-05 | 1.13e-04 | 108 |
GO:000657513 | Thyroid | PTC | cellular modified amino acid metabolic process | 85/5968 | 188/18723 | 8.29e-05 | 7.01e-04 | 85 |
GO:2000377110 | Thyroid | PTC | regulation of reactive oxygen species metabolic process | 71/5968 | 157/18723 | 3.03e-04 | 2.12e-03 | 71 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUOXA1 | SNV | Missense_Mutation | | c.1222C>T | p.Arg408Trp | p.R408W | Q1HG43 | protein_coding | deleterious_low_confidence(0.01) | benign(0.249) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DUOXA1 | deletion | Frame_Shift_Del | novel | c.140delN | p.Gly47GlufsTer12 | p.G47Efs*12 | Q1HG43 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DUOXA1 | SNV | Missense_Mutation | novel | c.1220C>A | p.Pro407Gln | p.P407Q | Q1HG43 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.694) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DUOXA1 | SNV | Missense_Mutation | | c.128N>G | p.Pro43Arg | p.P43R | Q1HG43 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-JW-A5VG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DUOXA1 | deletion | In_Frame_Del | novel | c.1014_1037delNNNNNNNNNNNNNNNNNNNNNNNN | p.Val339_Leu346del | p.V339_L346del | Q1HG43 | protein_coding | | | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
DUOXA1 | SNV | Missense_Mutation | | c.680C>T | p.Ala227Val | p.A227V | Q1HG43 | protein_coding | tolerated(0.17) | benign(0.03) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUOXA1 | SNV | Missense_Mutation | | c.1379N>A | p.Arg460His | p.R460H | Q1HG43 | protein_coding | deleterious_low_confidence(0) | benign(0.046) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DUOXA1 | SNV | Missense_Mutation | | c.1379N>A | p.Arg460His | p.R460H | Q1HG43 | protein_coding | deleterious_low_confidence(0) | benign(0.046) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DUOXA1 | SNV | Missense_Mutation | rs777729115 | c.169N>A | p.Val57Met | p.V57M | Q1HG43 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUOXA1 | SNV | Missense_Mutation | rs755140602 | c.1328G>A | p.Gly443Asp | p.G443D | Q1HG43 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |