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Gene: DENND11 |
Gene summary for DENND11 |
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Gene information | Species | Human | Gene symbol | DENND11 | Gene ID | 57189 |
Gene name | DENN domain containing 11 | |
Gene Alias | KIAA1147 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4D1U4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57189 | DENND11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.87e-02 | 1.07e-01 | -0.1808 |
57189 | DENND11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.73e-09 | 2.98e-01 | -0.0811 |
57189 | DENND11 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.71e-23 | 5.39e-01 | -0.1088 |
57189 | DENND11 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.88e-15 | 3.36e-01 | -0.1954 |
57189 | DENND11 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.07e-04 | 1.23e-01 | -0.1464 |
57189 | DENND11 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-08 | 1.81e-01 | -0.1001 |
57189 | DENND11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-09 | 2.19e-01 | -0.059 |
57189 | DENND11 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 2.45e-01 | -0.0842 |
57189 | DENND11 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 3.00e-01 | 0.0171 |
57189 | DENND11 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.67e-03 | 1.44e-01 | 0.0338 |
57189 | DENND11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.07e-07 | 1.74e-01 | 0.0674 |
57189 | DENND11 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.25e-06 | 3.09e-01 | 0.0112 |
57189 | DENND11 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.54e-06 | 2.30e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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