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Gene: CFAP44 |
Gene summary for CFAP44 |
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Gene information | Species | Human | Gene symbol | CFAP44 | Gene ID | 55779 |
Gene name | cilia and flagella associated protein 44 | |
Gene Alias | SPGF20 | |
Cytomap | 3q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96MT7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55779 | CFAP44 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.40e-19 | -5.84e-01 | 0.0155 |
55779 | CFAP44 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.24e-10 | -5.76e-01 | -0.1808 |
55779 | CFAP44 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.45e-03 | -6.06e-01 | 0.0216 |
55779 | CFAP44 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.83e-07 | -5.67e-01 | -0.0811 |
55779 | CFAP44 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.75e-14 | -5.89e-01 | -0.1088 |
55779 | CFAP44 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.14e-15 | -5.36e-01 | -0.1954 |
55779 | CFAP44 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.39e-02 | -6.06e-01 | -0.2196 |
55779 | CFAP44 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.50e-09 | -5.93e-01 | -0.1207 |
55779 | CFAP44 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.64e-06 | -5.75e-01 | -0.1526 |
55779 | CFAP44 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-27 | -5.93e-01 | -0.1464 |
55779 | CFAP44 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.06e-22 | -5.61e-01 | -0.1001 |
55779 | CFAP44 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.26e-14 | -5.70e-01 | -0.059 |
55779 | CFAP44 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.68e-05 | -6.06e-01 | -0.2061 |
55779 | CFAP44 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.45e-03 | -6.06e-01 | -0.1462 |
55779 | CFAP44 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.75e-08 | -6.06e-01 | -0.0842 |
55779 | CFAP44 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.05e-06 | -6.06e-01 | -0.0179 |
55779 | CFAP44 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.26e-18 | -5.86e-01 | 0.096 |
55779 | CFAP44 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.45e-03 | -6.06e-01 | 0.0446 |
55779 | CFAP44 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.06e-05 | -6.06e-01 | 0.0528 |
55779 | CFAP44 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.38e-04 | -5.84e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP44 | SNV | Missense_Mutation | novel | c.3028G>C | p.Glu1010Gln | p.E1010Q | protein_coding | tolerated(0.09) | possibly_damaging(0.629) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.3680N>G | p.Val1227Gly | p.V1227G | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | rs200395263 | c.3146N>G | p.Val1049Gly | p.V1049G | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | c.2246N>A | p.Ser749Tyr | p.S749Y | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CFAP44 | SNV | Missense_Mutation | c.3650T>C | p.Ile1217Thr | p.I1217T | protein_coding | deleterious(0) | possibly_damaging(0.86) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CFAP44 | SNV | Missense_Mutation | novel | c.3680N>G | p.Val1227Gly | p.V1227G | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
CFAP44 | SNV | Missense_Mutation | rs200395263 | c.3146N>G | p.Val1049Gly | p.V1049G | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
CFAP44 | SNV | Missense_Mutation | rs200395263 | c.3146N>G | p.Val1049Gly | p.V1049G | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-A2-A0T5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Taxotere | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.3680T>G | p.Val1227Gly | p.V1227G | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | c.218G>T | p.Ser73Ile | p.S73I | protein_coding | deleterious_low_confidence(0.01) | benign(0.316) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55779 | CFAP44 | PROTEASE | hmg coa reductase inhibitors | 25602530 |
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