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Gene: CAPN8 |
Gene summary for CAPN8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CAPN8 | Gene ID | 388743 |
Gene name | calpain 8 | |
Gene Alias | nCL-2 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A6NHC0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388743 | CAPN8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.45e-03 | -2.58e-01 | 0.0155 |
388743 | CAPN8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.59e-03 | 7.25e-01 | -0.1808 |
388743 | CAPN8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.43e-20 | 9.95e-01 | -0.0811 |
388743 | CAPN8 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.20e-03 | 3.63e-01 | -0.1954 |
388743 | CAPN8 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.72e-06 | 1.56e+00 | -0.2602 |
388743 | CAPN8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.58e-05 | 1.04e+00 | -0.2196 |
388743 | CAPN8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.81e-11 | 9.29e-01 | -0.059 |
388743 | CAPN8 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.79e-08 | -4.43e-01 | 0.096 |
388743 | CAPN8 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.35e-03 | 4.92e-01 | 0.0588 |
388743 | CAPN8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.35e-11 | -3.94e-01 | 0.3005 |
388743 | CAPN8 | A015-C-203 | Human | Colorectum | FAP | 9.76e-15 | -3.16e-01 | -0.1294 |
388743 | CAPN8 | A002-C-201 | Human | Colorectum | FAP | 5.45e-04 | -7.44e-02 | 0.0324 |
388743 | CAPN8 | A002-C-203 | Human | Colorectum | FAP | 6.98e-06 | 3.24e-01 | 0.2786 |
388743 | CAPN8 | A001-C-119 | Human | Colorectum | FAP | 4.85e-03 | -2.93e-01 | -0.1557 |
388743 | CAPN8 | A001-C-108 | Human | Colorectum | FAP | 3.38e-06 | 3.42e-02 | -0.0272 |
388743 | CAPN8 | A002-C-205 | Human | Colorectum | FAP | 1.08e-10 | -2.76e-01 | -0.1236 |
388743 | CAPN8 | A015-C-005 | Human | Colorectum | FAP | 1.24e-02 | -2.76e-01 | -0.0336 |
388743 | CAPN8 | A015-C-006 | Human | Colorectum | FAP | 1.13e-07 | -2.46e-01 | -0.0994 |
388743 | CAPN8 | A015-C-106 | Human | Colorectum | FAP | 1.78e-06 | -1.10e-01 | -0.0511 |
388743 | CAPN8 | A002-C-114 | Human | Colorectum | FAP | 9.76e-09 | -2.21e-01 | -0.1561 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007586 | Stomach | GC | digestion | 38/1159 | 137/18723 | 1.80e-15 | 1.22e-12 | 38 |
GO:00075861 | Stomach | CAG with IM | digestion | 29/1050 | 137/18723 | 4.42e-10 | 6.93e-08 | 29 |
GO:00075862 | Stomach | CSG | digestion | 25/1034 | 137/18723 | 1.15e-07 | 8.25e-06 | 25 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN8 | SNV | Missense_Mutation | novel | c.37N>C | p.Ala13Pro | p.A13P | A6NHC0 | protein_coding | tolerated(0.2) | possibly_damaging(0.603) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CAPN8 | SNV | Missense_Mutation | c.1913N>T | p.Gly638Val | p.G638V | A6NHC0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
CAPN8 | SNV | Missense_Mutation | c.211C>G | p.Gln71Glu | p.Q71E | A6NHC0 | protein_coding | tolerated(0.08) | benign(0.127) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CAPN8 | SNV | Missense_Mutation | novel | c.37N>C | p.Ala13Pro | p.A13P | A6NHC0 | protein_coding | tolerated(0.2) | possibly_damaging(0.603) | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN8 | SNV | Missense_Mutation | novel | c.37N>C | p.Ala13Pro | p.A13P | A6NHC0 | protein_coding | tolerated(0.2) | possibly_damaging(0.603) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CAPN8 | SNV | Missense_Mutation | novel | c.37N>C | p.Ala13Pro | p.A13P | A6NHC0 | protein_coding | tolerated(0.2) | possibly_damaging(0.603) | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CAPN8 | SNV | Missense_Mutation | novel | c.37N>C | p.Ala13Pro | p.A13P | A6NHC0 | protein_coding | tolerated(0.2) | possibly_damaging(0.603) | TCGA-B6-A0IH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CAPN8 | SNV | Missense_Mutation | novel | c.37N>C | p.Ala13Pro | p.A13P | A6NHC0 | protein_coding | tolerated(0.2) | possibly_damaging(0.603) | TCGA-BH-A0DL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
CAPN8 | SNV | Missense_Mutation | novel | c.2010N>G | p.Ile670Met | p.I670M | A6NHC0 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
CAPN8 | insertion | In_Frame_Ins | novel | c.49_50insATGGAGTCTTGCTCTGTCACCCAGGCTGGA | p.Gly17delinsAspGlyValLeuLeuCysHisProGlyTrpSer | p.G17delinsDGVLLCHPGWS | A6NHC0 | protein_coding | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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