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Gene: C7orf25 |
Gene summary for C7ORF25 |
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Gene information | Species | Human | Gene symbol | C7orf25 | Gene ID | 79020 |
Gene name | chromosome 7 open reading frame 25 | |
Gene Alias | C7orf25 | |
Cytomap | 7p14.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9BPX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79020 | C7orf25 | HCC1 | Human | Liver | HCC | 1.89e-02 | 1.19e+00 | 0.5336 |
79020 | C7orf25 | HCC2 | Human | Liver | HCC | 5.11e-07 | 1.37e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C7orf25 | SNV | Missense_Mutation | c.359N>T | p.Ser120Phe | p.S120F | Q9BPX7 | protein_coding | deleterious(0.01) | possibly_damaging(0.844) | TCGA-A8-A06R-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
C7orf25 | SNV | Missense_Mutation | c.262G>C | p.Gly88Arg | p.G88R | Q9BPX7 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C7orf25 | SNV | Missense_Mutation | novel | c.1421C>A | p.Thr474Lys | p.T474K | Q9BPX7 | protein_coding | tolerated_low_confidence(0.61) | benign(0.098) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C7orf25 | SNV | Missense_Mutation | c.1000C>T | p.Leu334Phe | p.L334F | Q9BPX7 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C7orf25 | SNV | Missense_Mutation | c.257N>T | p.Arg86Ile | p.R86I | Q9BPX7 | protein_coding | deleterious_low_confidence(0.02) | benign(0.189) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C7orf25 | SNV | Missense_Mutation | c.1373N>G | p.Leu458Arg | p.L458R | Q9BPX7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
C7orf25 | SNV | Missense_Mutation | c.318C>A | p.Phe106Leu | p.F106L | Q9BPX7 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
C7orf25 | SNV | Missense_Mutation | c.576N>T | p.Arg192Ser | p.R192S | Q9BPX7 | protein_coding | deleterious(0.02) | benign(0.17) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C7orf25 | deletion | Frame_Shift_Del | c.1281delN | p.Ala428ProfsTer4 | p.A428Pfs*4 | Q9BPX7 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
C7orf25 | SNV | Missense_Mutation | novel | c.334G>T | p.Ala112Ser | p.A112S | Q9BPX7 | protein_coding | tolerated(0.68) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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