![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C2orf72 |
Gene summary for C2ORF72 |
![]() |
Gene information | Species | Human | Gene symbol | C2orf72 | Gene ID | 257407 |
Gene name | chromosome 2 open reading frame 72 | |
Gene Alias | C2orf72 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6NCS6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
257407 | C2orf72 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.88e-28 | 8.84e-01 | -0.1954 |
257407 | C2orf72 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.57e-04 | 4.14e-01 | -0.1464 |
257407 | C2orf72 | A015-C-203 | Human | Colorectum | FAP | 3.76e-03 | -1.37e-01 | -0.1294 |
257407 | C2orf72 | A002-C-201 | Human | Colorectum | FAP | 1.03e-03 | -1.47e-01 | 0.0324 |
257407 | C2orf72 | A001-C-108 | Human | Colorectum | FAP | 4.14e-04 | -1.59e-01 | -0.0272 |
257407 | C2orf72 | A002-C-205 | Human | Colorectum | FAP | 3.96e-08 | -1.96e-01 | -0.1236 |
257407 | C2orf72 | A015-C-005 | Human | Colorectum | FAP | 3.33e-02 | -1.53e-01 | -0.0336 |
257407 | C2orf72 | A015-C-006 | Human | Colorectum | FAP | 6.53e-03 | -1.74e-01 | -0.0994 |
257407 | C2orf72 | A002-C-114 | Human | Colorectum | FAP | 1.03e-03 | -1.60e-01 | -0.1561 |
257407 | C2orf72 | A015-C-104 | Human | Colorectum | FAP | 1.16e-04 | -1.80e-01 | -0.1899 |
257407 | C2orf72 | A002-C-016 | Human | Colorectum | FAP | 2.52e-02 | -1.69e-01 | 0.0521 |
257407 | C2orf72 | A001-C-007 | Human | Colorectum | CRC | 4.53e-02 | -1.96e-01 | 0.1899 |
257407 | C2orf72 | A002-C-116 | Human | Colorectum | FAP | 9.56e-07 | -1.74e-01 | -0.0452 |
257407 | C2orf72 | A014-C-008 | Human | Colorectum | FAP | 2.33e-04 | -1.96e-01 | -0.191 |
257407 | C2orf72 | A018-E-020 | Human | Colorectum | FAP | 4.23e-04 | -1.66e-01 | -0.2034 |
257407 | C2orf72 | F034 | Human | Colorectum | FAP | 9.82e-07 | -1.83e-01 | -0.0665 |
257407 | C2orf72 | NAFLD1 | Human | Liver | NAFLD | 4.79e-08 | 6.10e-01 | -0.04 |
257407 | C2orf72 | S43 | Human | Liver | Cirrhotic | 2.38e-03 | -5.49e-02 | -0.0187 |
257407 | C2orf72 | HCC1_Meng | Human | Liver | HCC | 6.44e-41 | 1.91e-04 | 0.0246 |
257407 | C2orf72 | HCC2_Meng | Human | Liver | HCC | 5.11e-06 | -5.03e-02 | 0.0107 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C2orf72 | SNV | Missense_Mutation | novel | c.707N>T | p.Arg236Met | p.R236M | A6NCS6 | protein_coding | deleterious(0.02) | probably_damaging(0.912) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |