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Gene: C21orf59 |
Gene summary for C21ORF59 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C21orf59 | Gene ID | 56683 |
Gene name | cilia and flagella associated protein 298 | |
Gene Alias | C21orf48 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | P57076 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56683 | C21orf59 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.08e-11 | 2.22e-01 | 0.294 |
56683 | C21orf59 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.36e-07 | 6.78e-01 | 0.3487 |
56683 | C21orf59 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.24e-29 | 5.97e-01 | 0.3859 |
56683 | C21orf59 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.14e-04 | 1.99e-01 | 0.2585 |
56683 | C21orf59 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.92e-23 | 4.16e-01 | 0.3005 |
56683 | C21orf59 | P1T-E | Human | Esophagus | ESCC | 5.98e-11 | 5.60e-01 | 0.0875 |
56683 | C21orf59 | P2T-E | Human | Esophagus | ESCC | 6.66e-30 | 5.02e-01 | 0.1177 |
56683 | C21orf59 | P4T-E | Human | Esophagus | ESCC | 1.27e-39 | 9.44e-01 | 0.1323 |
56683 | C21orf59 | P5T-E | Human | Esophagus | ESCC | 4.08e-30 | 5.50e-01 | 0.1327 |
56683 | C21orf59 | P8T-E | Human | Esophagus | ESCC | 2.19e-18 | 3.90e-01 | 0.0889 |
56683 | C21orf59 | P9T-E | Human | Esophagus | ESCC | 8.20e-15 | 4.07e-01 | 0.1131 |
56683 | C21orf59 | P10T-E | Human | Esophagus | ESCC | 4.90e-34 | 8.94e-01 | 0.116 |
56683 | C21orf59 | P11T-E | Human | Esophagus | ESCC | 2.81e-11 | 5.34e-01 | 0.1426 |
56683 | C21orf59 | P12T-E | Human | Esophagus | ESCC | 4.94e-22 | 5.42e-01 | 0.1122 |
56683 | C21orf59 | P15T-E | Human | Esophagus | ESCC | 3.83e-13 | 3.02e-01 | 0.1149 |
56683 | C21orf59 | P16T-E | Human | Esophagus | ESCC | 9.88e-39 | 7.56e-01 | 0.1153 |
56683 | C21orf59 | P17T-E | Human | Esophagus | ESCC | 1.27e-09 | 3.84e-01 | 0.1278 |
56683 | C21orf59 | P19T-E | Human | Esophagus | ESCC | 2.76e-07 | 7.48e-01 | 0.1662 |
56683 | C21orf59 | P20T-E | Human | Esophagus | ESCC | 3.14e-25 | 5.20e-01 | 0.1124 |
56683 | C21orf59 | P21T-E | Human | Esophagus | ESCC | 2.14e-37 | 8.89e-01 | 0.1617 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C21orf59 | SNV | Missense_Mutation | novel | c.689N>A | p.Arg230Gln | p.R230Q | P57076 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C21orf59 | SNV | Missense_Mutation | c.31G>C | p.Glu11Gln | p.E11Q | P57076 | protein_coding | tolerated(0.2) | benign(0.287) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
C21orf59 | SNV | Missense_Mutation | novel | c.125N>G | p.Gln42Arg | p.Q42R | P57076 | protein_coding | tolerated(0.47) | benign(0.013) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | c.588G>T | p.Lys196Asn | p.K196N | P57076 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C21orf59 | SNV | Missense_Mutation | rs878855068 | c.250N>A | p.Val84Ile | p.V84I | P57076 | protein_coding | tolerated(1) | benign(0) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
C21orf59 | deletion | Frame_Shift_Del | c.246delN | p.Lys82AsnfsTer27 | p.K82Nfs*27 | P57076 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
C21orf59 | SNV | Missense_Mutation | novel | c.668N>T | p.Arg223Met | p.R223M | P57076 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | novel | c.172N>A | p.Leu58Ile | p.L58I | P57076 | protein_coding | tolerated(0.08) | possibly_damaging(0.521) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | novel | c.782A>G | p.Asp261Gly | p.D261G | P57076 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C21orf59 | SNV | Missense_Mutation | rs761867633 | c.494G>A | p.Arg165His | p.R165H | P57076 | protein_coding | deleterious(0.04) | probably_damaging(0.932) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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