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Gene: B9D1 |
Gene summary for B9D1 |
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Gene information | Species | Human | Gene symbol | B9D1 | Gene ID | 27077 |
Gene name | B9 domain containing 1 | |
Gene Alias | B9 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | A8MYG7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27077 | B9D1 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 4.43e-01 | 0.082 |
27077 | B9D1 | LZE4T | Human | Esophagus | ESCC | 1.47e-07 | 2.19e-01 | 0.0811 |
27077 | B9D1 | LZE7T | Human | Esophagus | ESCC | 9.32e-08 | 2.61e-01 | 0.0667 |
27077 | B9D1 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.45e-01 | 0.067 |
27077 | B9D1 | LZE24T | Human | Esophagus | ESCC | 1.68e-09 | 2.63e-01 | 0.0596 |
27077 | B9D1 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.08e-01 | 0.0655 |
27077 | B9D1 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.43e-01 | 0.0875 |
27077 | B9D1 | P2T-E | Human | Esophagus | ESCC | 2.77e-20 | 3.86e-01 | 0.1177 |
27077 | B9D1 | P4T-E | Human | Esophagus | ESCC | 1.46e-31 | 6.02e-01 | 0.1323 |
27077 | B9D1 | P5T-E | Human | Esophagus | ESCC | 1.39e-13 | 2.65e-01 | 0.1327 |
27077 | B9D1 | P8T-E | Human | Esophagus | ESCC | 2.85e-07 | 1.11e-01 | 0.0889 |
27077 | B9D1 | P9T-E | Human | Esophagus | ESCC | 2.79e-12 | 2.49e-01 | 0.1131 |
27077 | B9D1 | P10T-E | Human | Esophagus | ESCC | 1.42e-14 | 2.92e-01 | 0.116 |
27077 | B9D1 | P11T-E | Human | Esophagus | ESCC | 1.06e-12 | 4.56e-01 | 0.1426 |
27077 | B9D1 | P12T-E | Human | Esophagus | ESCC | 1.57e-07 | 3.01e-01 | 0.1122 |
27077 | B9D1 | P15T-E | Human | Esophagus | ESCC | 1.53e-11 | 2.41e-01 | 0.1149 |
27077 | B9D1 | P16T-E | Human | Esophagus | ESCC | 1.20e-37 | 7.25e-01 | 0.1153 |
27077 | B9D1 | P17T-E | Human | Esophagus | ESCC | 9.15e-12 | 3.22e-01 | 0.1278 |
27077 | B9D1 | P19T-E | Human | Esophagus | ESCC | 2.95e-08 | 5.23e-01 | 0.1662 |
27077 | B9D1 | P20T-E | Human | Esophagus | ESCC | 1.35e-11 | 2.28e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00487367 | Esophagus | ESCC | appendage development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00601737 | Esophagus | ESCC | limb development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:000170117 | Oral cavity | LP | in utero embryonic development | 142/4623 | 367/18723 | 1.48e-09 | 6.75e-08 | 142 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
B9D1 | insertion | Frame_Shift_Ins | novel | c.111_112insTGGCCAGTCCGCT | p.Gln38TrpfsTer38 | p.Q38Wfs*38 | Q9UPM9 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
B9D1 | insertion | Nonsense_Mutation | novel | c.361_362insGGCTGAGGAGAGCGTGAGCTTAGC | p.Met121delinsArgLeuArgArgAlaTerAlaTerLeu | p.M121delinsRLRRA*A*L | Q9UPM9 | protein_coding | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
B9D1 | SNV | Missense_Mutation | novel | c.418N>T | p.Arg140Trp | p.R140W | Q9UPM9 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
B9D1 | SNV | Missense_Mutation | c.565N>C | p.Asp189His | p.D189H | Q9UPM9 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
B9D1 | SNV | Missense_Mutation | rs771997194 | c.109N>A | p.Gly37Ser | p.G37S | Q9UPM9 | protein_coding | deleterious(0.02) | possibly_damaging(0.641) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
B9D1 | SNV | Missense_Mutation | novel | c.539N>C | p.Lys180Thr | p.K180T | Q9UPM9 | protein_coding | tolerated(0.13) | benign(0.04) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
B9D1 | SNV | Missense_Mutation | novel | c.600N>T | p.Gln200His | p.Q200H | Q9UPM9 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
B9D1 | SNV | Missense_Mutation | novel | c.79N>T | p.Asp27Tyr | p.D27Y | Q9UPM9 | protein_coding | tolerated(0.06) | benign(0.209) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
B9D1 | SNV | Missense_Mutation | novel | c.178N>A | p.Val60Met | p.V60M | Q9UPM9 | protein_coding | tolerated(0.1) | possibly_damaging(0.579) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
B9D1 | SNV | Missense_Mutation | c.220N>A | p.Phe74Ile | p.F74I | Q9UPM9 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-DD-A118-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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