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Gene: ARL6IP6 |
Gene summary for ARL6IP6 |
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Gene information | Species | Human | Gene symbol | ARL6IP6 | Gene ID | 151188 |
Gene name | ADP ribosylation factor like GTPase 6 interacting protein 6 | |
Gene Alias | AIP-6 | |
Cytomap | 2q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B3KMZ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151188 | ARL6IP6 | LZE2T | Human | Esophagus | ESCC | 1.77e-02 | 4.03e-01 | 0.082 |
151188 | ARL6IP6 | LZE4T | Human | Esophagus | ESCC | 2.74e-22 | 7.12e-01 | 0.0811 |
151188 | ARL6IP6 | LZE5T | Human | Esophagus | ESCC | 4.24e-02 | 1.69e-01 | 0.0514 |
151188 | ARL6IP6 | LZE7T | Human | Esophagus | ESCC | 2.90e-09 | 7.46e-01 | 0.0667 |
151188 | ARL6IP6 | LZE8T | Human | Esophagus | ESCC | 1.07e-10 | 4.31e-01 | 0.067 |
151188 | ARL6IP6 | LZE20T | Human | Esophagus | ESCC | 6.80e-07 | 3.43e-01 | 0.0662 |
151188 | ARL6IP6 | LZE22D1 | Human | Esophagus | HGIN | 3.43e-06 | 2.49e-01 | 0.0595 |
151188 | ARL6IP6 | LZE22T | Human | Esophagus | ESCC | 1.71e-06 | 8.00e-01 | 0.068 |
151188 | ARL6IP6 | LZE24T | Human | Esophagus | ESCC | 1.06e-31 | 8.20e-01 | 0.0596 |
151188 | ARL6IP6 | LZE21T | Human | Esophagus | ESCC | 9.73e-06 | 4.36e-01 | 0.0655 |
151188 | ARL6IP6 | LZE6T | Human | Esophagus | ESCC | 1.71e-14 | 6.18e-01 | 0.0845 |
151188 | ARL6IP6 | P1T-E | Human | Esophagus | ESCC | 2.08e-12 | 4.88e-01 | 0.0875 |
151188 | ARL6IP6 | P2T-E | Human | Esophagus | ESCC | 8.40e-51 | 8.79e-01 | 0.1177 |
151188 | ARL6IP6 | P4T-E | Human | Esophagus | ESCC | 2.35e-57 | 1.37e+00 | 0.1323 |
151188 | ARL6IP6 | P5T-E | Human | Esophagus | ESCC | 1.19e-32 | 7.38e-01 | 0.1327 |
151188 | ARL6IP6 | P8T-E | Human | Esophagus | ESCC | 2.38e-36 | 7.13e-01 | 0.0889 |
151188 | ARL6IP6 | P9T-E | Human | Esophagus | ESCC | 2.20e-12 | 2.96e-01 | 0.1131 |
151188 | ARL6IP6 | P10T-E | Human | Esophagus | ESCC | 1.25e-54 | 8.24e-01 | 0.116 |
151188 | ARL6IP6 | P11T-E | Human | Esophagus | ESCC | 9.49e-24 | 7.91e-01 | 0.1426 |
151188 | ARL6IP6 | P12T-E | Human | Esophagus | ESCC | 1.82e-101 | 1.74e+00 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL6IP6 | SNV | Missense_Mutation | novel | c.127G>A | p.Asp43Asn | p.D43N | Q8N6S5 | protein_coding | deleterious_low_confidence(0.02) | benign(0.127) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ARL6IP6 | SNV | Missense_Mutation | c.638N>C | p.Asn213Thr | p.N213T | Q8N6S5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL6IP6 | SNV | Missense_Mutation | c.578N>T | p.Ala193Val | p.A193V | Q8N6S5 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ARL6IP6 | SNV | Missense_Mutation | rs776457567 | c.209G>T | p.Arg70Leu | p.R70L | Q8N6S5 | protein_coding | tolerated_low_confidence(0.18) | benign(0.011) | TCGA-E2-A1AZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ARL6IP6 | SNV | Missense_Mutation | rs759482982 | c.516N>C | p.Trp172Cys | p.W172C | Q8N6S5 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-EW-A1PD-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | SD |
ARL6IP6 | SNV | Missense_Mutation | c.132N>C | p.Glu44Asp | p.E44D | Q8N6S5 | protein_coding | tolerated_low_confidence(0.26) | benign(0.001) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL6IP6 | SNV | Missense_Mutation | c.325N>A | p.Leu109Ile | p.L109I | Q8N6S5 | protein_coding | deleterious(0.03) | possibly_damaging(0.888) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL6IP6 | SNV | Missense_Mutation | c.376N>A | p.Ala126Thr | p.A126T | Q8N6S5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL6IP6 | SNV | Missense_Mutation | novel | c.484N>G | p.Thr162Ala | p.T162A | Q8N6S5 | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARL6IP6 | SNV | Missense_Mutation | novel | c.346C>T | p.Leu116Phe | p.L116F | Q8N6S5 | protein_coding | deleterious(0.02) | possibly_damaging(0.849) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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