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Gene: ZNF829 |
Gene summary for ZNF829 |
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Gene information | Species | Human | Gene symbol | ZNF829 | Gene ID | 374899 |
Gene name | zinc finger protein 829 | |
Gene Alias | ZNF829 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q3KNS6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374899 | ZNF829 | HCC1 | Human | Liver | HCC | 3.71e-02 | 1.57e+00 | 0.5336 |
374899 | ZNF829 | HCC2 | Human | Liver | HCC | 7.32e-06 | 1.24e+00 | 0.5341 |
374899 | ZNF829 | HCC5 | Human | Liver | HCC | 1.53e-02 | 2.39e-01 | 0.4932 |
374899 | ZNF829 | male-WTA | Human | Thyroid | PTC | 4.82e-02 | 5.89e-02 | 0.1037 |
374899 | ZNF829 | ATC13 | Human | Thyroid | ATC | 5.97e-59 | 9.08e-01 | 0.34 |
374899 | ZNF829 | ATC5 | Human | Thyroid | ATC | 1.84e-69 | 9.75e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF829 | SNV | Missense_Mutation | c.1358N>A | p.Arg453Lys | p.R453K | Q3KNS6 | protein_coding | tolerated(0.09) | possibly_damaging(0.878) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF829 | SNV | Missense_Mutation | c.852N>C | p.Gln284His | p.Q284H | Q3KNS6 | protein_coding | tolerated(0.06) | possibly_damaging(0.628) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF829 | SNV | Missense_Mutation | c.1522G>A | p.Glu508Lys | p.E508K | Q3KNS6 | protein_coding | deleterious(0.04) | benign(0.384) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
ZNF829 | SNV | Missense_Mutation | c.467G>C | p.Gly156Ala | p.G156A | Q3KNS6 | protein_coding | deleterious(0.02) | possibly_damaging(0.554) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ZNF829 | insertion | Frame_Shift_Ins | novel | c.340_341insATGGTATTTATTTTGAGAGAGGAAAAAGA | p.Gly114AspfsTer13 | p.G114Dfs*13 | Q3KNS6 | protein_coding | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF829 | SNV | Missense_Mutation | rs748080072 | c.43N>A | p.Gly15Arg | p.G15R | Q3KNS6 | protein_coding | deleterious_low_confidence(0.05) | unknown(0) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF829 | SNV | Missense_Mutation | novel | c.761N>T | p.Gln254Leu | p.Q254L | Q3KNS6 | protein_coding | tolerated(0.22) | probably_damaging(0.99) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF829 | SNV | Missense_Mutation | novel | c.1027C>T | p.His343Tyr | p.H343Y | Q3KNS6 | protein_coding | deleterious(0.01) | possibly_damaging(0.885) | TCGA-DS-A7WH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF829 | SNV | Missense_Mutation | c.874N>A | p.Pro292Thr | p.P292T | Q3KNS6 | protein_coding | deleterious(0.05) | benign(0.272) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF829 | insertion | In_Frame_Ins | novel | c.761_762insTGTTCG | p.Gln254delinsHisValArg | p.Q254delinsHVR | Q3KNS6 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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