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Gene: ZNF557 |
Gene summary for ZNF557 |
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Gene information | Species | Human | Gene symbol | ZNF557 | Gene ID | 79230 |
Gene name | zinc finger protein 557 | |
Gene Alias | ZNF557 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8N988 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79230 | ZNF557 | HCC1_Meng | Human | Liver | HCC | 2.43e-17 | -2.94e-02 | 0.0246 |
79230 | ZNF557 | HCC2_Meng | Human | Liver | HCC | 7.62e-07 | -1.34e-02 | 0.0107 |
79230 | ZNF557 | HCC1 | Human | Liver | HCC | 2.02e-06 | 2.80e+00 | 0.5336 |
79230 | ZNF557 | HCC2 | Human | Liver | HCC | 1.91e-13 | 1.53e+00 | 0.5341 |
79230 | ZNF557 | HCC5 | Human | Liver | HCC | 9.70e-07 | 8.72e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF557 | SNV | Missense_Mutation | c.681N>C | p.Lys227Asn | p.K227N | Q8N988 | protein_coding | deleterious(0.01) | possibly_damaging(0.534) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF557 | SNV | Missense_Mutation | c.341C>T | p.Pro114Leu | p.P114L | Q8N988 | protein_coding | tolerated(0.06) | benign(0.116) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF557 | SNV | Missense_Mutation | rs201284911 | c.926N>T | p.Ser309Leu | p.S309L | Q8N988 | protein_coding | tolerated(0.69) | benign(0) | TCGA-C5-A3HD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF557 | SNV | Missense_Mutation | rs561457120 | c.211N>A | p.Val71Met | p.V71M | Q8N988 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-Q1-A73Q-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF557 | SNV | Missense_Mutation | novel | c.278N>T | p.Ser93Phe | p.S93F | Q8N988 | protein_coding | tolerated(0.07) | benign(0.104) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF557 | SNV | Missense_Mutation | rs747902079 | c.1268N>T | p.Thr423Met | p.T423M | Q8N988 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | c.872N>G | p.His291Arg | p.H291R | Q8N988 | protein_coding | tolerated(0.09) | benign(0.352) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF557 | SNV | Missense_Mutation | rs577102341 | c.5N>T | p.Ala2Val | p.A2V | Q8N988 | protein_coding | deleterious(0.01) | probably_damaging(0.935) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | rs569224650 | c.811N>T | p.Arg271Cys | p.R271C | Q8N988 | protein_coding | deleterious(0) | benign(0.129) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF557 | SNV | Missense_Mutation | c.662N>G | p.Ser221Cys | p.S221C | Q8N988 | protein_coding | deleterious(0.03) | probably_damaging(0.923) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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