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Gene: ZNF530 |
Gene summary for ZNF530 |
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Gene information | Species | Human | Gene symbol | ZNF530 | Gene ID | 348327 |
Gene name | zinc finger protein 530 | |
Gene Alias | ZNF530 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6P9A1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
348327 | ZNF530 | HCC1 | Human | Liver | HCC | 9.63e-03 | 2.31e+00 | 0.5336 |
348327 | ZNF530 | HCC2 | Human | Liver | HCC | 2.47e-19 | 1.52e+00 | 0.5341 |
348327 | ZNF530 | HCC5 | Human | Liver | HCC | 2.05e-12 | 8.21e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF530 | SNV | Missense_Mutation | c.606N>T | p.Leu202Phe | p.L202F | Q6P9A1 | protein_coding | tolerated(0.71) | benign(0.222) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF530 | SNV | Missense_Mutation | c.895N>A | p.Glu299Lys | p.E299K | Q6P9A1 | protein_coding | deleterious(0.03) | possibly_damaging(0.838) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF530 | SNV | Missense_Mutation | rs370195949 | c.1103N>A | p.Arg368Gln | p.R368Q | Q6P9A1 | protein_coding | tolerated(0.86) | benign(0.031) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF530 | SNV | Missense_Mutation | c.67N>G | p.Phe23Val | p.F23V | Q6P9A1 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
ZNF530 | SNV | Missense_Mutation | c.992N>A | p.Ser331Tyr | p.S331Y | Q6P9A1 | protein_coding | deleterious(0.04) | probably_damaging(0.962) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ZNF530 | SNV | Missense_Mutation | novel | c.107N>A | p.Arg36Lys | p.R36K | Q6P9A1 | protein_coding | tolerated(0.1) | possibly_damaging(0.791) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF530 | SNV | Missense_Mutation | novel | c.1565A>G | p.Asp522Gly | p.D522G | Q6P9A1 | protein_coding | tolerated(0.31) | benign(0.006) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF530 | SNV | Missense_Mutation | c.596N>G | p.Ile199Ser | p.I199S | Q6P9A1 | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF530 | SNV | Missense_Mutation | rs760632344 | c.131T>C | p.Leu44Pro | p.L44P | Q6P9A1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF530 | SNV | Missense_Mutation | c.676T>G | p.Phe226Val | p.F226V | Q6P9A1 | protein_coding | deleterious(0.01) | benign(0.065) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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