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Gene: ZNF471 |
Gene summary for ZNF471 |
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Gene information | Species | Human | Gene symbol | ZNF471 | Gene ID | 57573 |
Gene name | zinc finger protein 471 | |
Gene Alias | ERP1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BX82 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57573 | ZNF471 | HCC1 | Human | Liver | HCC | 9.91e-07 | 2.30e+00 | 0.5336 |
57573 | ZNF471 | HCC2 | Human | Liver | HCC | 1.60e-20 | 3.32e+00 | 0.5341 |
57573 | ZNF471 | HCC5 | Human | Liver | HCC | 1.24e-02 | 2.05e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF471 | SNV | Missense_Mutation | c.1041A>T | p.Glu347Asp | p.E347D | Q9BX82 | protein_coding | deleterious(0.01) | benign(0.067) | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ZNF471 | SNV | Missense_Mutation | c.356N>G | p.Ser119Cys | p.S119C | Q9BX82 | protein_coding | tolerated(0.05) | possibly_damaging(0.533) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF471 | SNV | Missense_Mutation | c.1436N>T | p.Arg479Ile | p.R479I | Q9BX82 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF471 | SNV | Missense_Mutation | novel | c.773G>C | p.Gly258Ala | p.G258A | Q9BX82 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
ZNF471 | insertion | Frame_Shift_Ins | novel | c.643_644insG | p.Phe215CysfsTer4 | p.F215Cfs*4 | Q9BX82 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
ZNF471 | insertion | Frame_Shift_Ins | novel | c.643_644insGTTATGTACAGGCATG | p.Phe215CysfsTer9 | p.F215Cfs*9 | Q9BX82 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF471 | insertion | Frame_Shift_Ins | novel | c.1480_1481insAG | p.Ala495LysfsTer121 | p.A495Kfs*121 | Q9BX82 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF471 | SNV | Missense_Mutation | c.1268N>T | p.Arg423Ile | p.R423I | Q9BX82 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF471 | SNV | Missense_Mutation | novel | c.917C>T | p.Ala306Val | p.A306V | Q9BX82 | protein_coding | tolerated(0.6) | benign(0.227) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF471 | SNV | Missense_Mutation | c.1009N>G | p.Gln337Glu | p.Q337E | Q9BX82 | protein_coding | deleterious(0) | benign(0.209) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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