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Gene: ZNF395 |
Gene summary for ZNF395 |
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Gene information | Species | Human | Gene symbol | ZNF395 | Gene ID | 55893 |
Gene name | zinc finger protein 395 | |
Gene Alias | HDBP-2 | |
Cytomap | 8p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7L9C8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55893 | ZNF395 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.21e-03 | 3.62e-01 | -0.0811 |
55893 | ZNF395 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.68e-03 | 3.22e-01 | -0.1088 |
55893 | ZNF395 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.06e-07 | 3.38e-01 | -0.1954 |
55893 | ZNF395 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.23e-05 | 4.53e-01 | -0.0179 |
55893 | ZNF395 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.25e-02 | 3.97e-01 | -0.0177 |
55893 | ZNF395 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.17e-09 | 3.22e-01 | 0.0674 |
55893 | ZNF395 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.14e-03 | 6.16e-01 | -0.0124 |
55893 | ZNF395 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.94e-04 | 2.52e-01 | 0.294 |
55893 | ZNF395 | LZE4T | Human | Esophagus | ESCC | 2.27e-04 | 1.59e-02 | 0.0811 |
55893 | ZNF395 | LZE8T | Human | Esophagus | ESCC | 1.47e-05 | -1.33e-02 | 0.067 |
55893 | ZNF395 | LZE20T | Human | Esophagus | ESCC | 9.86e-03 | -1.28e-01 | 0.0662 |
55893 | ZNF395 | LZE22T | Human | Esophagus | ESCC | 2.98e-02 | 4.44e-02 | 0.068 |
55893 | ZNF395 | LZE24T | Human | Esophagus | ESCC | 9.61e-11 | 2.09e-01 | 0.0596 |
55893 | ZNF395 | P2T-E | Human | Esophagus | ESCC | 6.47e-32 | 2.22e-01 | 0.1177 |
55893 | ZNF395 | P4T-E | Human | Esophagus | ESCC | 3.53e-11 | 8.02e-02 | 0.1323 |
55893 | ZNF395 | P5T-E | Human | Esophagus | ESCC | 1.92e-08 | -1.16e-01 | 0.1327 |
55893 | ZNF395 | P8T-E | Human | Esophagus | ESCC | 9.18e-16 | 3.75e-01 | 0.0889 |
55893 | ZNF395 | P9T-E | Human | Esophagus | ESCC | 8.50e-05 | -5.33e-02 | 0.1131 |
55893 | ZNF395 | P10T-E | Human | Esophagus | ESCC | 2.40e-26 | 4.64e-01 | 0.116 |
55893 | ZNF395 | P11T-E | Human | Esophagus | ESCC | 6.01e-03 | 2.67e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF395 | SNV | Missense_Mutation | rs764292183 | c.1336C>T | p.Arg446Trp | p.R446W | Q9H8N7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF395 | SNV | Missense_Mutation | rs747728421 | c.1380N>T | p.Met460Ile | p.M460I | Q9H8N7 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF395 | SNV | Missense_Mutation | c.1322N>G | p.Ser441Cys | p.S441C | Q9H8N7 | protein_coding | deleterious(0.01) | probably_damaging(0.912) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF395 | insertion | Frame_Shift_Ins | novel | c.1337_1338insATGGGTGACTC | p.Ser447TrpfsTer6 | p.S447Wfs*6 | Q9H8N7 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF395 | SNV | Missense_Mutation | novel | c.805N>G | p.Pro269Ala | p.P269A | Q9H8N7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF395 | SNV | Missense_Mutation | rs142226591 | c.124G>A | p.Ala42Thr | p.A42T | Q9H8N7 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
ZNF395 | SNV | Missense_Mutation | c.1538N>G | p.Asp513Gly | p.D513G | Q9H8N7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF395 | SNV | Missense_Mutation | c.982C>A | p.Leu328Met | p.L328M | Q9H8N7 | protein_coding | tolerated(0.36) | benign(0) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
ZNF395 | SNV | Missense_Mutation | novel | c.1382N>C | p.Lys461Thr | p.K461T | Q9H8N7 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF395 | SNV | Missense_Mutation | c.88G>A | p.Ala30Thr | p.A30T | Q9H8N7 | protein_coding | tolerated(0.63) | benign(0.342) | TCGA-DM-A28C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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