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Gene: ZNF195 |
Gene summary for ZNF195 |
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Gene information | Species | Human | Gene symbol | ZNF195 | Gene ID | 7748 |
Gene name | zinc finger protein 195 | |
Gene Alias | HRF1 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O14628 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7748 | ZNF195 | LZE4T | Human | Esophagus | ESCC | 4.64e-03 | 8.30e-02 | 0.0811 |
7748 | ZNF195 | LZE7T | Human | Esophagus | ESCC | 1.77e-05 | 2.32e-01 | 0.0667 |
7748 | ZNF195 | LZE8T | Human | Esophagus | ESCC | 3.42e-04 | 8.68e-02 | 0.067 |
7748 | ZNF195 | LZE20T | Human | Esophagus | ESCC | 7.92e-03 | 6.17e-02 | 0.0662 |
7748 | ZNF195 | LZE24T | Human | Esophagus | ESCC | 3.03e-14 | 3.87e-01 | 0.0596 |
7748 | ZNF195 | LZE21T | Human | Esophagus | ESCC | 1.05e-02 | 1.85e-01 | 0.0655 |
7748 | ZNF195 | P1T-E | Human | Esophagus | ESCC | 4.31e-02 | 1.35e-01 | 0.0875 |
7748 | ZNF195 | P2T-E | Human | Esophagus | ESCC | 1.94e-26 | 5.52e-01 | 0.1177 |
7748 | ZNF195 | P4T-E | Human | Esophagus | ESCC | 2.74e-11 | 3.06e-01 | 0.1323 |
7748 | ZNF195 | P5T-E | Human | Esophagus | ESCC | 2.53e-06 | 5.12e-02 | 0.1327 |
7748 | ZNF195 | P8T-E | Human | Esophagus | ESCC | 2.31e-17 | 2.14e-01 | 0.0889 |
7748 | ZNF195 | P9T-E | Human | Esophagus | ESCC | 1.10e-06 | 1.33e-01 | 0.1131 |
7748 | ZNF195 | P10T-E | Human | Esophagus | ESCC | 4.66e-20 | 3.67e-01 | 0.116 |
7748 | ZNF195 | P11T-E | Human | Esophagus | ESCC | 1.00e-08 | 4.69e-01 | 0.1426 |
7748 | ZNF195 | P12T-E | Human | Esophagus | ESCC | 2.03e-22 | 3.95e-01 | 0.1122 |
7748 | ZNF195 | P15T-E | Human | Esophagus | ESCC | 2.04e-24 | 2.62e-01 | 0.1149 |
7748 | ZNF195 | P16T-E | Human | Esophagus | ESCC | 7.96e-08 | 1.70e-01 | 0.1153 |
7748 | ZNF195 | P17T-E | Human | Esophagus | ESCC | 6.23e-07 | 2.60e-01 | 0.1278 |
7748 | ZNF195 | P20T-E | Human | Esophagus | ESCC | 3.48e-17 | 2.61e-01 | 0.1124 |
7748 | ZNF195 | P21T-E | Human | Esophagus | ESCC | 1.96e-09 | 1.87e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF195 | SNV | Missense_Mutation | c.1237G>A | p.Glu413Lys | p.E413K | O14628 | protein_coding | tolerated(0.1) | possibly_damaging(0.663) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF195 | deletion | Frame_Shift_Del | novel | c.1312delN | p.Tyr438ThrfsTer184 | p.Y438Tfs*184 | O14628 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF195 | SNV | Missense_Mutation | c.712A>C | p.Asn238His | p.N238H | O14628 | protein_coding | tolerated(1) | benign(0) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
ZNF195 | SNV | Missense_Mutation | novel | c.710G>T | p.Ser237Ile | p.S237I | O14628 | protein_coding | tolerated(0.54) | benign(0.022) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF195 | SNV | Missense_Mutation | c.698N>C | p.Arg233Thr | p.R233T | O14628 | protein_coding | tolerated(0.2) | probably_damaging(0.966) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF195 | SNV | Missense_Mutation | novel | c.1040A>G | p.His347Arg | p.H347R | O14628 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
ZNF195 | SNV | Missense_Mutation | rs775701149 | c.1204A>G | p.Arg402Gly | p.R402G | O14628 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF195 | SNV | Missense_Mutation | c.155N>C | p.Leu52Pro | p.L52P | O14628 | protein_coding | deleterious(0.05) | possibly_damaging(0.766) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF195 | SNV | Missense_Mutation | rs748909798 | c.598N>T | p.Asp200Tyr | p.D200Y | O14628 | protein_coding | tolerated(0.15) | probably_damaging(0.99) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF195 | SNV | Missense_Mutation | rs559329436 | c.1484N>T | p.Thr495Met | p.T495M | O14628 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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