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Gene: ZNF181 |
Gene summary for ZNF181 |
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Gene information | Species | Human | Gene symbol | ZNF181 | Gene ID | 339318 |
Gene name | zinc finger protein 181 | |
Gene Alias | HHZ181 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DM69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339318 | ZNF181 | PTC04 | Human | Thyroid | PTC | 4.49e-03 | 2.49e-02 | 0.1927 |
339318 | ZNF181 | PTC05 | Human | Thyroid | PTC | 1.48e-03 | 1.06e-01 | 0.2065 |
339318 | ZNF181 | PTC07 | Human | Thyroid | PTC | 5.78e-08 | 1.06e-01 | 0.2044 |
339318 | ZNF181 | ATC13 | Human | Thyroid | ATC | 3.75e-33 | 6.10e-01 | 0.34 |
339318 | ZNF181 | ATC2 | Human | Thyroid | ATC | 2.92e-03 | 2.85e-01 | 0.34 |
339318 | ZNF181 | ATC5 | Human | Thyroid | ATC | 7.46e-35 | 6.71e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF181 | SNV | Missense_Mutation | c.1139G>C | p.Arg380Thr | p.R380T | Q2M3W8 | protein_coding | tolerated(0.19) | benign(0.027) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
ZNF181 | SNV | Missense_Mutation | c.829N>T | p.Gly277Cys | p.G277C | Q2M3W8 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-E2-A158-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | arimidex | SD | |
ZNF181 | SNV | Missense_Mutation | rs771789443 | c.527N>A | p.Ile176Asn | p.I176N | Q2M3W8 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF181 | SNV | Missense_Mutation | novel | c.1252N>C | p.Ser418Pro | p.S418P | Q2M3W8 | protein_coding | tolerated(0.07) | probably_damaging(0.939) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF181 | insertion | Frame_Shift_Ins | novel | c.1236_1237insCA | p.Val413GlnfsTer37 | p.V413Qfs*37 | Q2M3W8 | protein_coding | TCGA-EK-A2PK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF181 | SNV | Missense_Mutation | c.194T>C | p.Met65Thr | p.M65T | Q2M3W8 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF181 | SNV | Missense_Mutation | c.154N>C | p.Tyr52His | p.Y52H | Q2M3W8 | protein_coding | tolerated(0.35) | benign(0) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
ZNF181 | SNV | Missense_Mutation | c.1190N>T | p.Arg397Ile | p.R397I | Q2M3W8 | protein_coding | deleterious(0) | benign(0.386) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF181 | SNV | Missense_Mutation | c.1247N>T | p.Ser416Ile | p.S416I | Q2M3W8 | protein_coding | tolerated(0.18) | possibly_damaging(0.505) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF181 | SNV | Missense_Mutation | c.689C>T | p.Thr230Ile | p.T230I | Q2M3W8 | protein_coding | tolerated(0.13) | probably_damaging(0.979) | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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