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Gene: ZNF146 |
Gene summary for ZNF146 |
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Gene information | Species | Human | Gene symbol | ZNF146 | Gene ID | 7705 |
Gene name | zinc finger protein 146 | |
Gene Alias | OZF | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q15072 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7705 | ZNF146 | LZE4T | Human | Esophagus | ESCC | 3.24e-16 | 2.49e-01 | 0.0811 |
7705 | ZNF146 | LZE5T | Human | Esophagus | ESCC | 4.95e-03 | 3.87e-01 | 0.0514 |
7705 | ZNF146 | LZE7T | Human | Esophagus | ESCC | 2.91e-08 | 3.17e-01 | 0.0667 |
7705 | ZNF146 | LZE8T | Human | Esophagus | ESCC | 4.07e-09 | 1.92e-01 | 0.067 |
7705 | ZNF146 | LZE20T | Human | Esophagus | ESCC | 8.31e-07 | 7.68e-04 | 0.0662 |
7705 | ZNF146 | LZE22T | Human | Esophagus | ESCC | 1.09e-02 | 4.77e-02 | 0.068 |
7705 | ZNF146 | LZE24T | Human | Esophagus | ESCC | 4.50e-12 | 4.80e-01 | 0.0596 |
7705 | ZNF146 | LZE6T | Human | Esophagus | ESCC | 1.37e-08 | 2.76e-01 | 0.0845 |
7705 | ZNF146 | P1T-E | Human | Esophagus | ESCC | 9.37e-06 | 3.04e-01 | 0.0875 |
7705 | ZNF146 | P2T-E | Human | Esophagus | ESCC | 3.30e-23 | 4.28e-01 | 0.1177 |
7705 | ZNF146 | P4T-E | Human | Esophagus | ESCC | 1.18e-23 | 4.60e-01 | 0.1323 |
7705 | ZNF146 | P5T-E | Human | Esophagus | ESCC | 1.90e-17 | 1.74e-01 | 0.1327 |
7705 | ZNF146 | P8T-E | Human | Esophagus | ESCC | 1.45e-35 | 6.73e-01 | 0.0889 |
7705 | ZNF146 | P9T-E | Human | Esophagus | ESCC | 4.04e-11 | 2.94e-01 | 0.1131 |
7705 | ZNF146 | P10T-E | Human | Esophagus | ESCC | 3.38e-74 | 1.29e+00 | 0.116 |
7705 | ZNF146 | P11T-E | Human | Esophagus | ESCC | 8.85e-12 | 4.55e-01 | 0.1426 |
7705 | ZNF146 | P12T-E | Human | Esophagus | ESCC | 3.22e-29 | 6.49e-01 | 0.1122 |
7705 | ZNF146 | P15T-E | Human | Esophagus | ESCC | 5.72e-20 | 5.27e-01 | 0.1149 |
7705 | ZNF146 | P16T-E | Human | Esophagus | ESCC | 1.05e-20 | 3.90e-01 | 0.1153 |
7705 | ZNF146 | P17T-E | Human | Esophagus | ESCC | 2.94e-10 | 2.40e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF146 | SNV | Missense_Mutation | c.769N>G | p.Leu257Val | p.L257V | Q15072 | protein_coding | tolerated(0.52) | possibly_damaging(0.469) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF146 | SNV | Missense_Mutation | c.323N>T | p.Ala108Val | p.A108V | Q15072 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF146 | SNV | Missense_Mutation | c.266N>T | p.Thr89Met | p.T89M | Q15072 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF146 | SNV | Missense_Mutation | c.737G>A | p.Gly246Glu | p.G246E | Q15072 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF146 | SNV | Missense_Mutation | c.217G>A | p.Glu73Lys | p.E73K | Q15072 | protein_coding | tolerated(0.53) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF146 | SNV | Missense_Mutation | c.386T>C | p.Val129Ala | p.V129A | Q15072 | protein_coding | tolerated(0.16) | benign(0.254) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF146 | SNV | Missense_Mutation | novel | c.542A>G | p.Glu181Gly | p.E181G | Q15072 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | novel | c.716C>A | p.Pro239His | p.P239H | Q15072 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | novel | c.677C>T | p.Ser226Phe | p.S226F | Q15072 | protein_coding | tolerated(0.17) | probably_damaging(0.997) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF146 | SNV | Missense_Mutation | novel | c.352C>T | p.His118Tyr | p.H118Y | Q15072 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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