GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00196938 | Breast | Precancer | ribose phosphate metabolic process | 49/1080 | 396/18723 | 3.81e-07 | 1.78e-05 | 49 |
GO:00091509 | Breast | Precancer | purine ribonucleotide metabolic process | 46/1080 | 368/18723 | 6.47e-07 | 2.71e-05 | 46 |
GO:00091179 | Breast | Precancer | nucleotide metabolic process | 56/1080 | 489/18723 | 7.40e-07 | 3.00e-05 | 56 |
GO:00092598 | Breast | Precancer | ribonucleotide metabolic process | 47/1080 | 385/18723 | 9.69e-07 | 3.84e-05 | 47 |
GO:00469398 | Breast | Precancer | nucleotide phosphorylation | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:00067539 | Breast | Precancer | nucleoside phosphate metabolic process | 56/1080 | 497/18723 | 1.24e-06 | 4.70e-05 | 56 |
GO:00061639 | Breast | Precancer | purine nucleotide metabolic process | 47/1080 | 396/18723 | 2.14e-06 | 7.50e-05 | 47 |
GO:00091858 | Breast | Precancer | ribonucleoside diphosphate metabolic process | 20/1080 | 106/18723 | 2.37e-06 | 8.17e-05 | 20 |
GO:00060968 | Breast | Precancer | glycolytic process | 17/1080 | 81/18723 | 2.94e-06 | 9.73e-05 | 17 |
GO:00061658 | Breast | Precancer | nucleoside diphosphate phosphorylation | 19/1080 | 99/18723 | 3.23e-06 | 1.05e-04 | 19 |
GO:00067578 | Breast | Precancer | ATP generation from ADP | 17/1080 | 82/18723 | 3.52e-06 | 1.13e-04 | 17 |
GO:00434677 | Breast | Precancer | regulation of generation of precursor metabolites and energy | 22/1080 | 130/18723 | 4.95e-06 | 1.51e-04 | 22 |
GO:00091328 | Breast | Precancer | nucleoside diphosphate metabolic process | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00725219 | Breast | Precancer | purine-containing compound metabolic process | 47/1080 | 416/18723 | 8.19e-06 | 2.20e-04 | 47 |
GO:00460318 | Breast | Precancer | ADP metabolic process | 17/1080 | 90/18723 | 1.31e-05 | 3.30e-04 | 17 |
GO:00091359 | Breast | Precancer | purine nucleoside diphosphate metabolic process | 18/1080 | 103/18723 | 2.24e-05 | 5.20e-04 | 18 |
GO:00091799 | Breast | Precancer | purine ribonucleoside diphosphate metabolic process | 18/1080 | 103/18723 | 2.24e-05 | 5.20e-04 | 18 |
GO:00060908 | Breast | Precancer | pyruvate metabolic process | 18/1080 | 106/18723 | 3.35e-05 | 7.29e-04 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB2 | SNV | Missense_Mutation | | c.764N>T | p.Ala255Val | p.A255V | Q8N680 | protein_coding | tolerated(0.98) | benign(0.07) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB2 | SNV | Missense_Mutation | | c.233N>G | p.His78Arg | p.H78R | Q8N680 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AR-A1AW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
ZBTB2 | SNV | Missense_Mutation | | c.406C>G | p.Gln136Glu | p.Q136E | Q8N680 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZBTB2 | SNV | Missense_Mutation | | c.239N>A | p.Met80Lys | p.M80K | Q8N680 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-D8-A1XZ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen+anastrozolum | SD |
ZBTB2 | SNV | Missense_Mutation | | c.629N>G | p.Pro210Arg | p.P210R | Q8N680 | protein_coding | tolerated(0.58) | benign(0.044) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB2 | SNV | Missense_Mutation | | c.28N>G | p.Leu10Val | p.L10V | Q8N680 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZBTB2 | insertion | Frame_Shift_Ins | novel | c.823_824insCGAAGGGCGATCCATTCTCCTGGGC | p.Ile275ThrfsTer18 | p.I275Tfs*18 | Q8N680 | protein_coding | | | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZBTB2 | SNV | Missense_Mutation | | c.602N>T | p.Ser201Leu | p.S201L | Q8N680 | protein_coding | tolerated(0.22) | benign(0.144) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZBTB2 | SNV | Missense_Mutation | rs762417728 | c.635C>T | p.Pro212Leu | p.P212L | Q8N680 | protein_coding | tolerated(0.33) | benign(0.025) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZBTB2 | SNV | Missense_Mutation | rs191541534 | c.340N>A | p.Ala114Thr | p.A114T | Q8N680 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |