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Gene: WDR92 |
Gene summary for WDR92 |
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Gene information | Species | Human | Gene symbol | WDR92 | Gene ID | 116143 |
Gene name | dynein axonemal assembly factor 10 | |
Gene Alias | WDR92 | |
Cytomap | 2p14 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96MX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116143 | WDR92 | HCC1_Meng | Human | Liver | HCC | 2.74e-25 | 3.79e-02 | 0.0246 |
116143 | WDR92 | HCC1 | Human | Liver | HCC | 1.17e-19 | 2.23e+00 | 0.5336 |
116143 | WDR92 | HCC2 | Human | Liver | HCC | 1.69e-26 | 2.95e+00 | 0.5341 |
116143 | WDR92 | HCC5 | Human | Liver | HCC | 1.11e-27 | 1.86e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR92 | SNV | Missense_Mutation | novel | c.919N>A | p.Val307Ile | p.V307I | Q96MX6 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
WDR92 | SNV | Missense_Mutation | novel | c.301N>A | p.Glu101Lys | p.E101K | Q96MX6 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-E2-A1IH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
WDR92 | SNV | Missense_Mutation | c.874C>A | p.Pro292Thr | p.P292T | Q96MX6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-Q1-A6DV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR92 | SNV | Missense_Mutation | c.905N>A | p.Gly302Glu | p.G302E | Q96MX6 | protein_coding | deleterious(0.01) | possibly_damaging(0.684) | TCGA-AA-3666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
WDR92 | SNV | Missense_Mutation | c.662N>G | p.Asp221Gly | p.D221G | Q96MX6 | protein_coding | deleterious(0) | possibly_damaging(0.728) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WDR92 | SNV | Missense_Mutation | c.83N>T | p.Pro28Leu | p.P28L | Q96MX6 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WDR92 | SNV | Missense_Mutation | novel | c.230N>A | p.Ser77Tyr | p.S77Y | Q96MX6 | protein_coding | deleterious(0) | possibly_damaging(0.789) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDR92 | deletion | Frame_Shift_Del | c.125delN | p.Gly42AlafsTer15 | p.G42Afs*15 | Q96MX6 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
WDR92 | deletion | Frame_Shift_Del | c.629delN | p.Asn210MetfsTer13 | p.N210Mfs*13 | Q96MX6 | protein_coding | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WDR92 | SNV | Missense_Mutation | novel | c.128N>A | p.Thr43Asn | p.T43N | Q96MX6 | protein_coding | tolerated(0.06) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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