![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: U2AF1L5 |
Gene summary for U2AF1L5 |
![]() |
Gene information | Species | Human | Gene symbol | U2AF1L5 | Gene ID | 102724594 |
Gene name | U2 small nuclear RNA auxiliary factor 1 like 5 | |
Gene Alias | U2AF1L5 | |
Cytomap | 21p12 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P0DN76 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
102724594 | U2AF1L5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.74e-27 | 5.97e-01 | 0.0155 |
102724594 | U2AF1L5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.12e-37 | 9.95e-01 | -0.1808 |
102724594 | U2AF1L5 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.69e-11 | 8.43e-01 | 0.0216 |
102724594 | U2AF1L5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.37e-41 | 1.27e+00 | -0.0811 |
102724594 | U2AF1L5 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.92e-27 | 8.26e-01 | -0.1088 |
102724594 | U2AF1L5 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.57e-58 | 1.14e+00 | -0.1954 |
102724594 | U2AF1L5 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-15 | 1.26e+00 | -0.2602 |
102724594 | U2AF1L5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.60e-06 | 7.46e-01 | -0.2196 |
102724594 | U2AF1L5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.11e-20 | 8.71e-01 | -0.1207 |
102724594 | U2AF1L5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.43e-25 | 9.34e-01 | -0.1526 |
102724594 | U2AF1L5 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.96e-53 | 1.16e+00 | -0.1464 |
102724594 | U2AF1L5 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.44e-38 | 8.11e-01 | -0.1001 |
102724594 | U2AF1L5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.39e-53 | 1.40e+00 | -0.059 |
102724594 | U2AF1L5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.17e-17 | 8.61e-01 | -0.1706 |
102724594 | U2AF1L5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.29e-11 | 8.15e-01 | -0.2061 |
102724594 | U2AF1L5 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.16e-12 | 8.06e-01 | -0.1462 |
102724594 | U2AF1L5 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.92e-20 | 9.50e-01 | -0.0842 |
102724594 | U2AF1L5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.23e-04 | 6.40e-01 | -0.00410000000000005 |
102724594 | U2AF1L5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.08e-26 | 1.01e+00 | -0.0179 |
102724594 | U2AF1L5 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-47 | 1.17e+00 | 0.096 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa051315 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa051316 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa051317 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |