![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TSSC1 |
Gene summary for TSSC1 |
![]() |
Gene information | Species | Human | Gene symbol | TSSC1 | Gene ID | 7260 |
Gene name | EARP complex and GARP complex interacting protein 1 | |
Gene Alias | EIPR-1 | |
Cytomap | 2p25.3 | |
Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | A8MUM1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7260 | TSSC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.56e-16 | 3.43e-01 | 0.294 |
7260 | TSSC1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.11e-13 | 1.04e+00 | 0.3487 |
7260 | TSSC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.96e-16 | 4.47e-01 | 0.281 |
7260 | TSSC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.12e-29 | 5.52e-01 | 0.3859 |
7260 | TSSC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.22e-05 | 2.27e-01 | 0.2585 |
7260 | TSSC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.75e-18 | 3.54e-01 | 0.3005 |
7260 | TSSC1 | P1T-E | Human | Esophagus | ESCC | 8.92e-04 | 2.29e-01 | 0.0875 |
7260 | TSSC1 | P2T-E | Human | Esophagus | ESCC | 9.57e-45 | 6.47e-01 | 0.1177 |
7260 | TSSC1 | P4T-E | Human | Esophagus | ESCC | 4.60e-21 | 4.93e-01 | 0.1323 |
7260 | TSSC1 | P5T-E | Human | Esophagus | ESCC | 2.45e-21 | 3.49e-01 | 0.1327 |
7260 | TSSC1 | P8T-E | Human | Esophagus | ESCC | 5.45e-26 | 3.63e-01 | 0.0889 |
7260 | TSSC1 | P9T-E | Human | Esophagus | ESCC | 8.21e-07 | 2.04e-01 | 0.1131 |
7260 | TSSC1 | P10T-E | Human | Esophagus | ESCC | 6.11e-29 | 5.04e-01 | 0.116 |
7260 | TSSC1 | P11T-E | Human | Esophagus | ESCC | 2.33e-07 | 4.10e-01 | 0.1426 |
7260 | TSSC1 | P12T-E | Human | Esophagus | ESCC | 3.26e-17 | 2.94e-01 | 0.1122 |
7260 | TSSC1 | P15T-E | Human | Esophagus | ESCC | 1.93e-08 | 2.27e-01 | 0.1149 |
7260 | TSSC1 | P16T-E | Human | Esophagus | ESCC | 1.30e-16 | 2.30e-01 | 0.1153 |
7260 | TSSC1 | P17T-E | Human | Esophagus | ESCC | 2.41e-06 | 2.23e-01 | 0.1278 |
7260 | TSSC1 | P19T-E | Human | Esophagus | ESCC | 4.96e-08 | 6.67e-01 | 0.1662 |
7260 | TSSC1 | P20T-E | Human | Esophagus | ESCC | 2.78e-19 | 4.23e-01 | 0.1124 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSSC1 | SNV | Missense_Mutation | c.385N>T | p.Pro129Ser | p.P129S | protein_coding | tolerated(0.05) | benign(0.177) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
TSSC1 | SNV | Missense_Mutation | c.560T>C | p.Leu187Pro | p.L187P | protein_coding | tolerated(0.09) | benign(0.445) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TSSC1 | SNV | Missense_Mutation | novel | c.1186N>A | p.Asp396Asn | p.D396N | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
TSSC1 | SNV | Missense_Mutation | novel | c.500N>C | p.Val167Ala | p.V167A | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSSC1 | SNV | Missense_Mutation | novel | c.301N>T | p.Gly101Trp | p.G101W | protein_coding | deleterious_low_confidence(0.03) | benign(0.017) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TSSC1 | insertion | Nonsense_Mutation | novel | c.864_865insCATCACTAGGGG | p.Val288_Thr289insHisHisTerGly | p.V288_T289insHH*G | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TSSC1 | SNV | Missense_Mutation | rs766526306 | c.916C>T | p.Arg306Cys | p.R306C | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TSSC1 | SNV | Missense_Mutation | rs376448610 | c.547N>A | p.Asp183Asn | p.D183N | protein_coding | tolerated(0.05) | benign(0.111) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | SD | ||
TSSC1 | SNV | Missense_Mutation | novel | c.4G>C | p.Glu2Gln | p.E2Q | protein_coding | deleterious(0.01) | possibly_damaging(0.551) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSSC1 | SNV | Missense_Mutation | novel | c.691N>A | p.Ala231Thr | p.A231T | protein_coding | deleterious(0.01) | benign(0.17) | TCGA-ZJ-AAXI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |