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Gene: TPP1 |
Gene summary for TPP1 |
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Gene information | Species | Human | Gene symbol | TPP1 | Gene ID | 1200 |
Gene name | tripeptidyl peptidase 1 | |
Gene Alias | CLN2 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | O14773 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1200 | TPP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.41e-09 | 4.39e-01 | -0.1808 |
1200 | TPP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.07e-12 | 3.49e-01 | -0.1954 |
1200 | TPP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.87e-02 | 2.36e-01 | -0.1526 |
1200 | TPP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.32e-05 | 3.09e-01 | -0.059 |
1200 | TPP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.42e-02 | 3.16e-01 | -0.1462 |
1200 | TPP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.14e-09 | 3.37e-01 | 0.096 |
1200 | TPP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.40e-05 | 2.64e-01 | 0.294 |
1200 | TPP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.01e-10 | 3.92e-01 | 0.281 |
1200 | TPP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.01e-12 | 4.00e-01 | 0.3859 |
1200 | TPP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.08e-02 | 1.95e-01 | 0.2585 |
1200 | TPP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.11e-03 | 1.97e-01 | 0.3005 |
1200 | TPP1 | LZE4T | Human | Esophagus | ESCC | 8.73e-04 | 2.18e-01 | 0.0811 |
1200 | TPP1 | LZE7T | Human | Esophagus | ESCC | 1.18e-09 | 2.82e-01 | 0.0667 |
1200 | TPP1 | LZE8T | Human | Esophagus | ESCC | 1.55e-06 | 1.48e-01 | 0.067 |
1200 | TPP1 | LZE20T | Human | Esophagus | ESCC | 2.82e-02 | -3.85e-03 | 0.0662 |
1200 | TPP1 | LZE22D1 | Human | Esophagus | HGIN | 1.16e-02 | -1.66e-02 | 0.0595 |
1200 | TPP1 | LZE22T | Human | Esophagus | ESCC | 7.75e-06 | 1.29e-01 | 0.068 |
1200 | TPP1 | LZE24T | Human | Esophagus | ESCC | 1.12e-20 | 6.31e-01 | 0.0596 |
1200 | TPP1 | LZE21T | Human | Esophagus | ESCC | 3.29e-03 | 7.45e-02 | 0.0655 |
1200 | TPP1 | P1T-E | Human | Esophagus | ESCC | 3.95e-07 | 2.19e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091418 | Breast | Precancer | nucleoside triphosphate metabolic process | 26/1080 | 112/18723 | 7.72e-10 | 6.66e-08 | 26 |
GO:00091179 | Breast | Precancer | nucleotide metabolic process | 56/1080 | 489/18723 | 7.40e-07 | 3.00e-05 | 56 |
GO:00067539 | Breast | Precancer | nucleoside phosphate metabolic process | 56/1080 | 497/18723 | 1.24e-06 | 4.70e-05 | 56 |
GO:00346558 | Breast | Precancer | nucleobase-containing compound catabolic process | 42/1080 | 407/18723 | 1.91e-04 | 3.06e-03 | 42 |
GO:00467007 | Breast | Precancer | heterocycle catabolic process | 44/1080 | 445/18723 | 3.49e-04 | 4.88e-03 | 44 |
GO:00442708 | Breast | Precancer | cellular nitrogen compound catabolic process | 44/1080 | 451/18723 | 4.64e-04 | 6.12e-03 | 44 |
GO:00714969 | Breast | Precancer | cellular response to external stimulus | 33/1080 | 320/18723 | 9.01e-04 | 1.03e-02 | 33 |
GO:00194397 | Breast | Precancer | aromatic compound catabolic process | 44/1080 | 467/18723 | 9.55e-04 | 1.07e-02 | 44 |
GO:00316688 | Breast | Precancer | cellular response to extracellular stimulus | 27/1080 | 246/18723 | 1.02e-03 | 1.13e-02 | 27 |
GO:19013617 | Breast | Precancer | organic cyclic compound catabolic process | 45/1080 | 495/18723 | 1.73e-03 | 1.74e-02 | 45 |
GO:000914114 | Breast | IDC | nucleoside triphosphate metabolic process | 29/1434 | 112/18723 | 3.68e-09 | 3.03e-07 | 29 |
GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
GO:000911713 | Breast | IDC | nucleotide metabolic process | 67/1434 | 489/18723 | 2.28e-06 | 9.05e-05 | 67 |
GO:007149614 | Breast | IDC | cellular response to external stimulus | 45/1434 | 320/18723 | 5.40e-05 | 1.15e-03 | 45 |
GO:003166814 | Breast | IDC | cellular response to extracellular stimulus | 35/1434 | 246/18723 | 2.79e-04 | 4.26e-03 | 35 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
GO:001943912 | Breast | IDC | aromatic compound catabolic process | 51/1434 | 467/18723 | 6.54e-03 | 4.59e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TPP1 | SNV | Missense_Mutation | c.508G>A | p.Val170Met | p.V170M | O14773 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TPP1 | SNV | Missense_Mutation | c.1514N>T | p.Pro505Leu | p.P505L | O14773 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
TPP1 | SNV | Missense_Mutation | novel | c.312N>T | p.Leu104Phe | p.L104F | O14773 | protein_coding | deleterious(0.05) | benign(0.165) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
TPP1 | SNV | Missense_Mutation | rs149529997 | c.1526N>G | p.Gln509Arg | p.Q509R | O14773 | protein_coding | tolerated(0.12) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
TPP1 | SNV | Missense_Mutation | rs778410642 | c.802N>T | p.Arg268Trp | p.R268W | O14773 | protein_coding | deleterious(0.02) | possibly_damaging(0.812) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TPP1 | SNV | Missense_Mutation | rs769487055 | c.1279A>T | p.Thr427Ser | p.T427S | O14773 | protein_coding | tolerated(0.84) | benign(0) | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
TPP1 | SNV | Missense_Mutation | rs368914445 | c.1123C>T | p.Arg375Cys | p.R375C | O14773 | protein_coding | tolerated(0.06) | probably_damaging(0.99) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TPP1 | SNV | Missense_Mutation | rs140176031 | c.776N>A | p.Arg259His | p.R259H | O14773 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AA-A024-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TPP1 | SNV | Missense_Mutation | c.1157N>A | p.Thr386Asn | p.T386N | O14773 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
TPP1 | SNV | Missense_Mutation | c.800N>C | p.Gly267Ala | p.G267A | O14773 | protein_coding | tolerated(0.13) | benign(0.14) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1200 | TPP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | Cerliponase Alfa | |||
1200 | TPP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | cerliponase alfa | |||
1200 | TPP1 | PROTEASE, ENZYME, DRUGGABLE GENOME | Cerliponase Alfa |
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