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Gene: TMEM74B |
Gene summary for TMEM74B |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM74B | Gene ID | 55321 |
Gene name | transmembrane protein 74B | |
Gene Alias | C20orf46 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NUR3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55321 | TMEM74B | HCC1_Meng | Human | Liver | HCC | 1.52e-08 | 1.79e-02 | 0.0246 |
55321 | TMEM74B | Pt13.b | Human | Liver | HCC | 4.52e-03 | 1.36e-01 | 0.0251 |
55321 | TMEM74B | S014 | Human | Liver | HCC | 1.18e-23 | 9.06e-01 | 0.2254 |
55321 | TMEM74B | S015 | Human | Liver | HCC | 1.80e-23 | 9.10e-01 | 0.2375 |
55321 | TMEM74B | S016 | Human | Liver | HCC | 2.43e-38 | 9.78e-01 | 0.2243 |
55321 | TMEM74B | S028 | Human | Liver | HCC | 1.58e-20 | 6.31e-01 | 0.2503 |
55321 | TMEM74B | S029 | Human | Liver | HCC | 5.64e-17 | 5.23e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM74B | SNV | Missense_Mutation | c.197C>T | p.Ser66Leu | p.S66L | Q9NUR3 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM74B | SNV | Missense_Mutation | rs201827576 | c.469N>T | p.Arg157Trp | p.R157W | Q9NUR3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A423-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TMEM74B | SNV | Missense_Mutation | novel | c.512N>T | p.Ser171Phe | p.S171F | Q9NUR3 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
TMEM74B | SNV | Missense_Mutation | rs201827576 | c.469C>T | p.Arg157Trp | p.R157W | Q9NUR3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM74B | SNV | Missense_Mutation | novel | c.256A>G | p.Ser86Gly | p.S86G | Q9NUR3 | protein_coding | deleterious(0.05) | probably_damaging(0.969) | TCGA-5M-AATE-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMEM74B | SNV | Missense_Mutation | c.23N>C | p.Glu8Ala | p.E8A | Q9NUR3 | protein_coding | tolerated_low_confidence(0.73) | benign(0.003) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM74B | SNV | Missense_Mutation | rs377316018 | c.376N>A | p.Ala126Thr | p.A126T | Q9NUR3 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM74B | SNV | Missense_Mutation | c.200N>C | p.Glu67Ala | p.E67A | Q9NUR3 | protein_coding | deleterious(0) | benign(0.246) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
TMEM74B | SNV | Missense_Mutation | novel | c.605G>A | p.Gly202Asp | p.G202D | Q9NUR3 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM74B | SNV | Missense_Mutation | rs781279001 | c.467N>T | p.Ala156Val | p.A156V | Q9NUR3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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