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Gene: TMEM47 |
Gene summary for TMEM47 |
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Gene information | Species | Human | Gene symbol | TMEM47 | Gene ID | 83604 |
Gene name | transmembrane protein 47 | |
Gene Alias | BCMP1 | |
Cytomap | Xp21.1 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | A0A024RBY7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83604 | TMEM47 | P2T-E | Human | Esophagus | ESCC | 9.49e-04 | 6.16e-02 | 0.1177 |
83604 | TMEM47 | P9T-E | Human | Esophagus | ESCC | 4.82e-02 | 1.04e-01 | 0.1131 |
83604 | TMEM47 | P10T-E | Human | Esophagus | ESCC | 3.43e-03 | 3.64e-02 | 0.116 |
83604 | TMEM47 | P11T-E | Human | Esophagus | ESCC | 7.66e-09 | 5.22e-01 | 0.1426 |
83604 | TMEM47 | P12T-E | Human | Esophagus | ESCC | 3.77e-02 | 7.21e-02 | 0.1122 |
83604 | TMEM47 | P19T-E | Human | Esophagus | ESCC | 3.72e-06 | 6.46e-01 | 0.1662 |
83604 | TMEM47 | P32T-E | Human | Esophagus | ESCC | 5.05e-05 | 2.24e-01 | 0.1666 |
83604 | TMEM47 | P42T-E | Human | Esophagus | ESCC | 1.23e-03 | 2.84e-01 | 0.1175 |
83604 | TMEM47 | P44T-E | Human | Esophagus | ESCC | 1.04e-09 | 3.44e-01 | 0.1096 |
83604 | TMEM47 | P47T-E | Human | Esophagus | ESCC | 1.10e-02 | 2.97e-02 | 0.1067 |
83604 | TMEM47 | P57T-E | Human | Esophagus | ESCC | 1.35e-02 | 1.01e-01 | 0.0926 |
83604 | TMEM47 | P61T-E | Human | Esophagus | ESCC | 9.15e-06 | 1.66e-01 | 0.099 |
83604 | TMEM47 | P76T-E | Human | Esophagus | ESCC | 3.32e-05 | 1.13e-01 | 0.1207 |
83604 | TMEM47 | P79T-E | Human | Esophagus | ESCC | 3.54e-61 | 1.28e+00 | 0.1154 |
83604 | TMEM47 | P107T-E | Human | Esophagus | ESCC | 1.17e-02 | 2.38e-01 | 0.171 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM47 | SNV | Missense_Mutation | novel | c.83N>C | p.Phe28Ser | p.F28S | Q9BQJ4 | protein_coding | deleterious(0.03) | benign(0.212) | TCGA-EK-A2PK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM47 | SNV | Missense_Mutation | novel | c.176N>A | p.Arg59Gln | p.R59Q | Q9BQJ4 | protein_coding | tolerated(0.63) | benign(0.028) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM47 | SNV | Missense_Mutation | novel | c.31N>A | p.Val11Met | p.V11M | Q9BQJ4 | protein_coding | tolerated(0.1) | possibly_damaging(0.459) | TCGA-VS-A9UP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TMEM47 | SNV | Missense_Mutation | c.41N>T | p.Ser14Leu | p.S14L | Q9BQJ4 | protein_coding | tolerated(0.35) | benign(0.063) | TCGA-A6-2684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM47 | SNV | Missense_Mutation | c.300N>T | p.Leu100Phe | p.L100F | Q9BQJ4 | protein_coding | deleterious(0.01) | possibly_damaging(0.813) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TMEM47 | SNV | Missense_Mutation | c.110N>T | p.Ala37Val | p.A37V | Q9BQJ4 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
TMEM47 | SNV | Missense_Mutation | c.407A>C | p.Lys136Thr | p.K136T | Q9BQJ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM47 | SNV | Missense_Mutation | novel | c.535N>T | p.Asp179Tyr | p.D179Y | Q9BQJ4 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM47 | SNV | Missense_Mutation | rs779449154 | c.265G>A | p.Ala89Thr | p.A89T | Q9BQJ4 | protein_coding | tolerated(0.25) | possibly_damaging(0.49) | TCGA-AG-A01W-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
TMEM47 | SNV | Missense_Mutation | novel | c.34N>T | p.Arg12Cys | p.R12C | Q9BQJ4 | protein_coding | deleterious(0) | possibly_damaging(0.68) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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