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Gene: TMEM134 |
Gene summary for TMEM134 |
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Gene information | Species | Human | Gene symbol | TMEM134 | Gene ID | 80194 |
Gene name | transmembrane protein 134 | |
Gene Alias | TMEM134 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6X4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80194 | TMEM134 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.80e-07 | 3.79e-01 | -0.1808 |
80194 | TMEM134 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.01e-03 | 3.63e-01 | -0.0811 |
80194 | TMEM134 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.11e-05 | 2.73e-01 | -0.1954 |
80194 | TMEM134 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.50e-07 | 3.70e-01 | -0.1207 |
80194 | TMEM134 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.18e-15 | 3.77e-01 | -0.1464 |
80194 | TMEM134 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.89e-10 | 2.77e-01 | -0.1001 |
80194 | TMEM134 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.06e-14 | 4.40e-01 | -0.059 |
80194 | TMEM134 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.22e-02 | 3.08e-01 | -0.0842 |
80194 | TMEM134 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.88e-02 | 2.69e-01 | 0.0528 |
80194 | TMEM134 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.12e-03 | 3.92e-01 | 0.0131 |
80194 | TMEM134 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.08e-04 | 2.90e-01 | 0.0338 |
80194 | TMEM134 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.51e-14 | 3.26e-01 | 0.0674 |
80194 | TMEM134 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.44e-07 | 3.49e-01 | 0.0588 |
80194 | TMEM134 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.45e-10 | 2.80e-01 | 0.294 |
80194 | TMEM134 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.08e-02 | 2.50e-01 | 0.281 |
80194 | TMEM134 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.14e-11 | 3.29e-01 | 0.3859 |
80194 | TMEM134 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.59e-11 | 2.55e-01 | 0.3005 |
80194 | TMEM134 | LZE2T | Human | Esophagus | ESCC | 1.14e-05 | 8.80e-01 | 0.082 |
80194 | TMEM134 | LZE4T | Human | Esophagus | ESCC | 1.11e-23 | 5.51e-01 | 0.0811 |
80194 | TMEM134 | LZE5T | Human | Esophagus | ESCC | 4.89e-04 | 3.42e-01 | 0.0514 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM134 | SNV | Missense_Mutation | c.469N>A | p.Phe157Ile | p.F157I | Q9H6X4 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM134 | SNV | Missense_Mutation | rs754993164 | c.308G>A | p.Arg103His | p.R103H | Q9H6X4 | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM134 | SNV | Missense_Mutation | c.503N>C | p.Gly168Ala | p.G168A | Q9H6X4 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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