Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/TMCO1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TMCO1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TMCO1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/TMCO1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TMCO1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TMCO1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TMCO1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/TMCO1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TMCO1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TMCO1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00712167 | Breast | Precancer | cellular response to biotic stimulus | 28/1080 | 246/18723 | 4.67e-04 | 6.14e-03 | 28 |
GO:00324697 | Breast | Precancer | endoplasmic reticulum calcium ion homeostasis | 6/1080 | 25/18723 | 2.49e-03 | 2.28e-02 | 6 |
GO:00069845 | Breast | Precancer | ER-nucleus signaling pathway | 8/1080 | 46/18723 | 4.40e-03 | 3.43e-02 | 8 |
GO:0072503 | Breast | Precancer | cellular divalent inorganic cation homeostasis | 42/1080 | 486/18723 | 5.91e-03 | 4.21e-02 | 42 |
GO:003497614 | Breast | IDC | response to endoplasmic reticulum stress | 43/1434 | 256/18723 | 8.42e-07 | 3.82e-05 | 43 |
GO:003246913 | Breast | IDC | endoplasmic reticulum calcium ion homeostasis | 8/1434 | 25/18723 | 3.85e-04 | 5.40e-03 | 8 |
GO:000698412 | Breast | IDC | ER-nucleus signaling pathway | 10/1434 | 46/18723 | 2.15e-03 | 2.00e-02 | 10 |
GO:007121611 | Breast | IDC | cellular response to biotic stimulus | 31/1434 | 246/18723 | 4.23e-03 | 3.31e-02 | 31 |
GO:003497622 | Breast | DCIS | response to endoplasmic reticulum stress | 43/1390 | 256/18723 | 3.65e-07 | 1.71e-05 | 43 |
GO:000698421 | Breast | DCIS | ER-nucleus signaling pathway | 10/1390 | 46/18723 | 1.70e-03 | 1.68e-02 | 10 |
GO:003246922 | Breast | DCIS | endoplasmic reticulum calcium ion homeostasis | 7/1390 | 25/18723 | 1.79e-03 | 1.73e-02 | 7 |
GO:007121621 | Breast | DCIS | cellular response to biotic stimulus | 30/1390 | 246/18723 | 4.99e-03 | 3.72e-02 | 30 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0032469 | Colorectum | AD | endoplasmic reticulum calcium ion homeostasis | 16/3918 | 25/18723 | 3.80e-06 | 1.04e-04 | 16 |
GO:0006984 | Colorectum | AD | ER-nucleus signaling pathway | 21/3918 | 46/18723 | 1.47e-04 | 2.08e-03 | 21 |
GO:00349762 | Colorectum | MSS | response to endoplasmic reticulum stress | 81/3467 | 256/18723 | 2.65e-07 | 1.10e-05 | 81 |
GO:00324692 | Colorectum | MSS | endoplasmic reticulum calcium ion homeostasis | 16/3467 | 25/18723 | 6.86e-07 | 2.48e-05 | 16 |
GO:00069842 | Colorectum | MSS | ER-nucleus signaling pathway | 19/3467 | 46/18723 | 2.79e-04 | 3.69e-03 | 19 |
GO:0006983 | Colorectum | MSS | ER overload response | 7/3467 | 13/18723 | 4.46e-03 | 3.15e-02 | 7 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMCO1 | SNV | Missense_Mutation | | c.354G>C | p.Lys118Asn | p.K118N | | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMCO1 | SNV | Missense_Mutation | novel | c.143N>A | p.Arg48Gln | p.R48Q | | protein_coding | deleterious_low_confidence(0.03) | benign(0.034) | TCGA-BH-A0HB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
TMCO1 | SNV | Missense_Mutation | | c.442T>A | p.Cys148Ser | p.C148S | | protein_coding | tolerated(0.34) | benign(0.006) | TCGA-D8-A146-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMCO1 | SNV | Missense_Mutation | | c.410N>C | p.Val137Ala | p.V137A | | protein_coding | tolerated(0.19) | possibly_damaging(0.469) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
TMCO1 | SNV | Missense_Mutation | | c.332N>T | p.Ser111Leu | p.S111L | | protein_coding | tolerated(0.11) | possibly_damaging(0.861) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMCO1 | SNV | Missense_Mutation | rs763875549 | c.413G>A | p.Arg138Gln | p.R138Q | | protein_coding | deleterious(0.01) | possibly_damaging(0.591) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMCO1 | SNV | Missense_Mutation | | c.236T>A | p.Val79Asp | p.V79D | | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMCO1 | SNV | Missense_Mutation | novel | c.586N>G | p.Phe196Val | p.F196V | | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMCO1 | SNV | Missense_Mutation | novel | c.527T>C | p.Ile176Thr | p.I176T | | protein_coding | deleterious(0.03) | benign(0.041) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TMCO1 | SNV | Missense_Mutation | rs763875549 | c.413G>A | p.Arg138Gln | p.R138Q | | protein_coding | deleterious(0.01) | possibly_damaging(0.591) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |