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Gene: SMIM12 |
Gene summary for SMIM12 |
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Gene information | Species | Human | Gene symbol | SMIM12 | Gene ID | 113444 |
Gene name | small integral membrane protein 12 | |
Gene Alias | C1orf212 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | L0R6D7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113444 | SMIM12 | LZE2D | Human | Esophagus | HGIN | 5.77e-03 | 2.77e-01 | 0.0642 |
113444 | SMIM12 | LZE2T | Human | Esophagus | ESCC | 5.96e-07 | 8.98e-01 | 0.082 |
113444 | SMIM12 | LZE4T | Human | Esophagus | ESCC | 6.92e-15 | 1.97e-01 | 0.0811 |
113444 | SMIM12 | LZE7T | Human | Esophagus | ESCC | 1.87e-08 | 4.76e-01 | 0.0667 |
113444 | SMIM12 | LZE8T | Human | Esophagus | ESCC | 1.17e-03 | 2.35e-01 | 0.067 |
113444 | SMIM12 | LZE20T | Human | Esophagus | ESCC | 3.35e-09 | 2.69e-01 | 0.0662 |
113444 | SMIM12 | LZE22D1 | Human | Esophagus | HGIN | 1.59e-05 | 2.42e-01 | 0.0595 |
113444 | SMIM12 | LZE22T | Human | Esophagus | ESCC | 4.79e-03 | 3.64e-01 | 0.068 |
113444 | SMIM12 | LZE24T | Human | Esophagus | ESCC | 4.39e-18 | 5.12e-01 | 0.0596 |
113444 | SMIM12 | LZE6T | Human | Esophagus | ESCC | 1.34e-05 | 4.02e-01 | 0.0845 |
113444 | SMIM12 | P1T-E | Human | Esophagus | ESCC | 4.24e-10 | 4.69e-01 | 0.0875 |
113444 | SMIM12 | P2T-E | Human | Esophagus | ESCC | 1.11e-27 | 4.75e-01 | 0.1177 |
113444 | SMIM12 | P4T-E | Human | Esophagus | ESCC | 2.41e-25 | 5.71e-01 | 0.1323 |
113444 | SMIM12 | P5T-E | Human | Esophagus | ESCC | 9.53e-22 | 5.03e-01 | 0.1327 |
113444 | SMIM12 | P8T-E | Human | Esophagus | ESCC | 1.29e-15 | 3.66e-01 | 0.0889 |
113444 | SMIM12 | P9T-E | Human | Esophagus | ESCC | 1.33e-12 | 2.83e-01 | 0.1131 |
113444 | SMIM12 | P10T-E | Human | Esophagus | ESCC | 1.22e-20 | 3.42e-01 | 0.116 |
113444 | SMIM12 | P11T-E | Human | Esophagus | ESCC | 3.28e-18 | 7.91e-01 | 0.1426 |
113444 | SMIM12 | P12T-E | Human | Esophagus | ESCC | 2.27e-15 | 3.60e-01 | 0.1122 |
113444 | SMIM12 | P15T-E | Human | Esophagus | ESCC | 4.10e-25 | 5.64e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMIM12 | SNV | Missense_Mutation | novel | c.31A>G | p.Thr11Ala | p.T11A | Q96EX1 | protein_coding | tolerated(0.12) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SMIM12 | SNV | Missense_Mutation | rs764683292 | c.166C>T | p.Arg56Cys | p.R56C | Q96EX1 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SMIM12 | SNV | Missense_Mutation | c.179A>G | p.Glu60Gly | p.E60G | Q96EX1 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SMIM12 | SNV | Missense_Mutation | rs753993701 | c.263N>A | p.Arg88His | p.R88H | Q96EX1 | protein_coding | tolerated(0.23) | probably_damaging(0.991) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMIM12 | SNV | Missense_Mutation | novel | c.92N>G | p.Leu31Arg | p.L31R | Q96EX1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM12 | SNV | Missense_Mutation | novel | c.273G>T | p.Lys91Asn | p.K91N | Q96EX1 | protein_coding | tolerated_low_confidence(0.18) | possibly_damaging(0.634) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM12 | SNV | Missense_Mutation | novel | c.22N>A | p.Val8Met | p.V8M | Q96EX1 | protein_coding | tolerated(0.3) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMIM12 | SNV | Missense_Mutation | c.179N>T | p.Glu60Val | p.E60V | Q96EX1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-DD-AAEA-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SMIM12 | SNV | Missense_Mutation | novel | c.247G>C | p.Val83Leu | p.V83L | Q96EX1 | protein_coding | deleterious(0.04) | benign(0.12) | TCGA-39-5027-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SMIM12 | SNV | Missense_Mutation | c.184N>G | p.Leu62Val | p.L62V | Q96EX1 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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