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Gene: SLC16A10 |
Gene summary for SLC16A10 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SLC16A10 | Gene ID | 117247 |
| Gene name | solute carrier family 16 member 10 | |
| Gene Alias | MCT10 | |
| Cytomap | 6q21 | |
| Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | Q8TF71 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 117247 | SLC16A10 | TD9 | Human | Lung | IAC | 4.12e-03 | 8.27e-01 | 0.088 |
| 117247 | SLC16A10 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.33e-16 | 7.01e-01 | -0.2116 |
| 117247 | SLC16A10 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.17e-06 | 7.07e-01 | -0.1941 |
| 117247 | SLC16A10 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.99e-11 | 6.22e-01 | -0.2119 |
| 117247 | SLC16A10 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 4.99e-02 | 7.71e-01 | -0.0296 |
| 117247 | SLC16A10 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.28e-02 | 7.54e-01 | -0.0263 |
| 117247 | SLC16A10 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 3.85e-10 | 4.08e-01 | -0.0166 |
| 117247 | SLC16A10 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.65e-14 | 4.84e-01 | -0.0132 |
| 117247 | SLC16A10 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 6.85e-17 | 5.17e-01 | -0.013 |
| 117247 | SLC16A10 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 9.06e-09 | 3.72e-01 | -0.0121 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Breast | Precancer |  |
| Breast | IDC |  |
| Breast | DCIS |  |
| Cervix | CC |  |
| Cervix | HSIL_HPV |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0491914 | Lung | IAC | Thyroid hormone signaling pathway | 27/1053 | 121/8465 | 1.61e-03 | 9.49e-03 | 6.30e-03 | 27 |
| hsa0491915 | Lung | IAC | Thyroid hormone signaling pathway | 27/1053 | 121/8465 | 1.61e-03 | 9.49e-03 | 6.30e-03 | 27 |
| hsa0491921 | Lung | AIS | Thyroid hormone signaling pathway | 27/961 | 121/8465 | 3.92e-04 | 3.85e-03 | 2.47e-03 | 27 |
| hsa0491931 | Lung | AIS | Thyroid hormone signaling pathway | 27/961 | 121/8465 | 3.92e-04 | 3.85e-03 | 2.47e-03 | 27 |
| hsa0491941 | Lung | MIAC | Thyroid hormone signaling pathway | 16/507 | 121/8465 | 2.23e-03 | 2.03e-02 | 1.47e-02 | 16 |
| hsa0491951 | Lung | MIAC | Thyroid hormone signaling pathway | 16/507 | 121/8465 | 2.23e-03 | 2.03e-02 | 1.47e-02 | 16 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SLC16A10 | SNV | Missense_Mutation | c.962G>T | p.Arg321Ile | p.R321I | Q8TF71 | protein_coding | deleterious(0.03) | benign(0.281) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SLC16A10 | SNV | Missense_Mutation | rs774929205 | c.1324C>T | p.Arg442Cys | p.R442C | Q8TF71 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SLC16A10 | SNV | Missense_Mutation | c.611N>A | p.Gly204Asp | p.G204D | Q8TF71 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SLC16A10 | SNV | Missense_Mutation | novel | c.806N>A | p.Ser269Tyr | p.S269Y | Q8TF71 | protein_coding | deleterious(0.04) | benign(0.242) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SLC16A10 | insertion | Nonsense_Mutation | novel | c.607_608insTGTCATAATTCCCCCCACGCTTTCCCTTCTTTTACAGC | p.Asn203MetfsTer3 | p.N203Mfs*3 | Q8TF71 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
| SLC16A10 | SNV | Missense_Mutation | c.962N>T | p.Arg321Ile | p.R321I | Q8TF71 | protein_coding | deleterious(0.03) | benign(0.281) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| SLC16A10 | SNV | Missense_Mutation | rs772294671 | c.592C>T | p.Arg198Cys | p.R198C | Q8TF71 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SLC16A10 | SNV | Missense_Mutation | novel | c.482T>G | p.Phe161Cys | p.F161C | Q8TF71 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SLC16A10 | SNV | Missense_Mutation | c.518G>T | p.Gly173Val | p.G173V | Q8TF71 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| SLC16A10 | SNV | Missense_Mutation | novel | c.1186G>A | p.Asp396Asn | p.D396N | Q8TF71 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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