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Gene: RNF223 |
Gene summary for RNF223 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RNF223 | Gene ID | 401934 |
Gene name | ring finger protein 223 | |
Gene Alias | RNF223 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | E7ERA6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401934 | RNF223 | LZE24T | Human | Esophagus | ESCC | 1.92e-08 | 3.77e-01 | 0.0596 |
401934 | RNF223 | P1T-E | Human | Esophagus | ESCC | 7.10e-06 | 4.28e-01 | 0.0875 |
401934 | RNF223 | P4T-E | Human | Esophagus | ESCC | 4.13e-15 | 4.01e-01 | 0.1323 |
401934 | RNF223 | P8T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.95e-01 | 0.0889 |
401934 | RNF223 | P28T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.28e-01 | 0.1149 |
401934 | RNF223 | P31T-E | Human | Esophagus | ESCC | 1.44e-02 | 1.75e-01 | 0.1251 |
401934 | RNF223 | P39T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.89e-01 | 0.0894 |
401934 | RNF223 | P40T-E | Human | Esophagus | ESCC | 1.21e-02 | 2.32e-01 | 0.109 |
401934 | RNF223 | P47T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.64e-01 | 0.1067 |
401934 | RNF223 | P49T-E | Human | Esophagus | ESCC | 6.27e-03 | 2.62e-01 | 0.1768 |
401934 | RNF223 | P52T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.30e-01 | 0.1555 |
401934 | RNF223 | P54T-E | Human | Esophagus | ESCC | 3.58e-04 | 1.77e-01 | 0.0975 |
401934 | RNF223 | P57T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.18e-01 | 0.0926 |
401934 | RNF223 | P74T-E | Human | Esophagus | ESCC | 3.95e-05 | 2.28e-01 | 0.1479 |
401934 | RNF223 | P75T-E | Human | Esophagus | ESCC | 5.88e-35 | 9.10e-01 | 0.1125 |
401934 | RNF223 | P76T-E | Human | Esophagus | ESCC | 4.16e-02 | 1.09e-01 | 0.1207 |
401934 | RNF223 | P80T-E | Human | Esophagus | ESCC | 2.47e-08 | 4.17e-01 | 0.155 |
401934 | RNF223 | P82T-E | Human | Esophagus | ESCC | 6.42e-11 | 6.58e-01 | 0.1072 |
401934 | RNF223 | P84T-E | Human | Esophagus | ESCC | 2.46e-04 | 5.83e-01 | 0.0933 |
401934 | RNF223 | P104T-E | Human | Esophagus | ESCC | 9.48e-07 | 4.65e-01 | 0.0931 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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