Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RFX7_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RFX7_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RFX7_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RFX7_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/RFX7_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
RFX7 | TFH | Breast | ADJ | XKR6,BMPR2,CSGALNACT1, etc. | 8.90e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
RFX7 | PLA | Breast | DCIS | XKR6,BMPR2,CSGALNACT1, etc. | 1.15e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
RFX7 | BMEM | Breast | DCIS | XKR6,BMPR2,CSGALNACT1, etc. | 9.22e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
RFX7 | CD8TEFF | Breast | Healthy | XKR6,BMPR2,CSGALNACT1, etc. | 5.47e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
RFX7 | TFH | Breast | IDC | XKR6,BMPR2,CSGALNACT1, etc. | 1.33e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
RFX7 | CD8TEFF | Breast | Precancer | XKR6,BMPR2,CSGALNACT1, etc. | 6.06e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
RFX7 | MAIT | Colorectum | AD | POGLUT1,RTKN2,EGLN1, etc. | 1.24e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_AD/regulons_activity_in_dotplot.png) |
RFX7 | TREG | Colorectum | ADJ | POGLUT1,RTKN2,EGLN1, etc. | 1.16e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
RFX7 | TREG | Colorectum | CRC | POGLUT1,RTKN2,EGLN1, etc. | 1.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
RFX7 | TH1 | Colorectum | CRC | POGLUT1,RTKN2,EGLN1, etc. | 1.96e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RFX7 | SNV | Missense_Mutation | | c.739C>G | p.Leu247Val | p.L247V | Q2KHR2 | protein_coding | tolerated(0.1) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RFX7 | SNV | Missense_Mutation | | c.2555N>T | p.Thr852Ile | p.T852I | Q2KHR2 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RFX7 | SNV | Missense_Mutation | novel | c.858G>C | p.Met286Ile | p.M286I | Q2KHR2 | protein_coding | tolerated(0.21) | benign(0) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR |
RFX7 | SNV | Missense_Mutation | novel | c.1333N>A | p.Glu445Lys | p.E445K | Q2KHR2 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RFX7 | insertion | Frame_Shift_Ins | novel | c.1707_1708insTTGGCAGCTTTAATCCAAATGGATGGCA | p.Thr570LeufsTer37 | p.T570Lfs*37 | Q2KHR2 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
RFX7 | insertion | In_Frame_Ins | novel | c.2840_2841insCAACTTCAGATGCCGGAGTGTGAGCCCTGCTGT | p.Ser947_Pro948insAsnPheArgCysArgSerValSerProAlaVal | p.S947_P948insNFRCRSVSPAV | Q2KHR2 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RFX7 | insertion | Frame_Shift_Ins | novel | c.2579_2580insAAATCTTTAT | p.Pro861AsnfsTer13 | p.P861Nfs*13 | Q2KHR2 | protein_coding | | | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
RFX7 | insertion | In_Frame_Ins | novel | c.2577_2578insGAAGCC | p.Pro859_Thr860insGluAla | p.P859_T860insEA | Q2KHR2 | protein_coding | | | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
RFX7 | insertion | Nonsense_Mutation | novel | c.1584_1585insCTTTTAGCTTAATAATAGTGGAGATAGGAGGTTCAAGGGTTC | p.Ser528_Val529insLeuLeuAlaTerTerTerTrpArgTerGluValGlnGlyPhe | p.S528_V529insLLA***WR*EVQGF | Q2KHR2 | protein_coding | | | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
RFX7 | deletion | Frame_Shift_Del | novel | c.2588delN | p.Pro863GlnfsTer9 | p.P863Qfs*9 | Q2KHR2 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |