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Gene: REG4 |
Gene summary for REG4 |
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Gene information | Species | Human | Gene symbol | REG4 | Gene ID | 83998 |
Gene name | regenerating family member 4 | |
Gene Alias | GISP | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R0M1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83998 | REG4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.56e-53 | 4.85e+00 | -0.1808 |
83998 | REG4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.00e-26 | 2.05e+00 | -0.0811 |
83998 | REG4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.16e-34 | 2.67e+00 | -0.1088 |
83998 | REG4 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.16e-37 | 5.67e+00 | -0.2602 |
83998 | REG4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.86e-22 | 3.24e+00 | -0.2196 |
83998 | REG4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.30e-11 | 1.18e+00 | -0.1207 |
83998 | REG4 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.98e-07 | 9.25e-01 | -0.1526 |
83998 | REG4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.52e-49 | 2.21e+00 | -0.1464 |
83998 | REG4 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.60e-02 | 4.58e-01 | -0.1001 |
83998 | REG4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.23e-25 | 1.31e+00 | -0.059 |
83998 | REG4 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.96e-02 | 4.04e-01 | -0.0842 |
83998 | REG4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.14e-05 | 2.39e-01 | 0.096 |
83998 | REG4 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.13e-21 | 2.01e+00 | 0.0446 |
83998 | REG4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.73e-21 | 1.67e+00 | 0.0528 |
83998 | REG4 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.65e-10 | 7.04e-01 | 0.0171 |
83998 | REG4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.32e-02 | 8.81e-02 | 0.0674 |
83998 | REG4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.28e-07 | 3.22e-01 | 0.0588 |
83998 | REG4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.12e-18 | 2.06e+00 | 0.3487 |
83998 | REG4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.09e-05 | 3.09e-01 | 0.281 |
83998 | REG4 | Pat01-B | Human | Stomach | GC | 6.15e-46 | 1.14e+00 | 0.5754 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REG4 | SNV | Missense_Mutation | novel | c.261N>C | p.Gln87His | p.Q87H | Q9BYZ8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
REG4 | SNV | Missense_Mutation | c.292N>C | p.Asp98His | p.D98H | Q9BYZ8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-5255-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
REG4 | SNV | Missense_Mutation | c.365N>A | p.Ser122Tyr | p.S122Y | Q9BYZ8 | protein_coding | deleterious(0.05) | possibly_damaging(0.704) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
REG4 | SNV | Missense_Mutation | rs780517734 | c.398N>A | p.Ser133Asn | p.S133N | Q9BYZ8 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
REG4 | SNV | Missense_Mutation | rs747842213 | c.20N>A | p.Arg7Gln | p.R7Q | Q9BYZ8 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
REG4 | SNV | Missense_Mutation | novel | c.61N>A | p.Leu21Met | p.L21M | Q9BYZ8 | protein_coding | tolerated(0.08) | possibly_damaging(0.753) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REG4 | SNV | Missense_Mutation | novel | c.329G>A | p.Gly110Glu | p.G110E | Q9BYZ8 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REG4 | SNV | Missense_Mutation | rs150927973 | c.433G>A | p.Glu145Lys | p.E145K | Q9BYZ8 | protein_coding | tolerated(0.41) | benign(0.045) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REG4 | SNV | Missense_Mutation | rs143957193 | c.446N>A | p.Arg149His | p.R149H | Q9BYZ8 | protein_coding | tolerated(0.32) | benign(0.014) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REG4 | SNV | Missense_Mutation | novel | c.28N>A | p.Leu10Ile | p.L10I | Q9BYZ8 | protein_coding | deleterious(0.02) | benign(0.189) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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