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Gene: PRUNE2 |
Gene summary for PRUNE2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PRUNE2 | Gene ID | 158471 |
Gene name | prune homolog 2 with BCH domain | |
Gene Alias | BMCC1 | |
Cytomap | 9q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | A0A088AWP5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158471 | PRUNE2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.90e-27 | 1.26e+00 | -0.0811 |
158471 | PRUNE2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.52e-22 | 1.08e+00 | -0.1088 |
158471 | PRUNE2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.39e-11 | 6.78e-01 | -0.1954 |
158471 | PRUNE2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.77e-02 | 5.43e-01 | -0.1464 |
158471 | PRUNE2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.65e-08 | 8.04e-01 | -0.1001 |
158471 | PRUNE2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.36e-05 | 6.37e-01 | -0.059 |
158471 | PRUNE2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.85e-03 | 6.13e-01 | 0.0446 |
158471 | PRUNE2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.58e-03 | 4.63e-01 | 0.0338 |
158471 | PRUNE2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.28e-22 | 1.21e+00 | 0.0588 |
158471 | PRUNE2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.74e-26 | 9.75e-01 | 0.294 |
158471 | PRUNE2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.62e-07 | 1.43e+00 | 0.3487 |
158471 | PRUNE2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.58e-27 | 1.86e+00 | 0.281 |
158471 | PRUNE2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.38e-21 | 1.17e+00 | 0.3859 |
158471 | PRUNE2 | A002-C-010 | Human | Colorectum | FAP | 1.49e-07 | 5.51e-01 | 0.242 |
158471 | PRUNE2 | A001-C-207 | Human | Colorectum | FAP | 1.61e-07 | 5.91e-01 | 0.1278 |
158471 | PRUNE2 | A015-C-203 | Human | Colorectum | FAP | 5.80e-05 | 1.69e-01 | -0.1294 |
158471 | PRUNE2 | A002-C-201 | Human | Colorectum | FAP | 1.89e-05 | 3.88e-01 | 0.0324 |
158471 | PRUNE2 | A002-C-203 | Human | Colorectum | FAP | 3.36e-18 | 7.92e-01 | 0.2786 |
158471 | PRUNE2 | A001-C-108 | Human | Colorectum | FAP | 3.00e-07 | 4.45e-01 | -0.0272 |
158471 | PRUNE2 | A002-C-021 | Human | Colorectum | FAP | 2.15e-11 | 5.42e-01 | 0.1171 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRUNE2 | SNV | Missense_Mutation | c.1727G>A | p.Ser576Asn | p.S576N | Q8WUY3 | protein_coding | tolerated(0.67) | benign(0.033) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
PRUNE2 | SNV | Missense_Mutation | c.6274N>T | p.His2092Tyr | p.H2092Y | Q8WUY3 | protein_coding | deleterious(0.02) | benign(0.082) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PRUNE2 | SNV | Missense_Mutation | c.2489A>T | p.Asp830Val | p.D830V | Q8WUY3 | protein_coding | tolerated(0.25) | benign(0.079) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PRUNE2 | SNV | Missense_Mutation | novel | c.2258N>A | p.Thr753Lys | p.T753K | Q8WUY3 | protein_coding | deleterious(0.02) | benign(0.115) | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRUNE2 | SNV | Missense_Mutation | rs769204874 | c.8323G>A | p.Val2775Met | p.V2775M | Q8WUY3 | protein_coding | tolerated(0.73) | benign(0.007) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRUNE2 | SNV | Missense_Mutation | c.7295N>T | p.Ser2432Phe | p.S2432F | Q8WUY3 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRUNE2 | SNV | Missense_Mutation | c.6113N>G | p.Ser2038Cys | p.S2038C | Q8WUY3 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRUNE2 | SNV | Missense_Mutation | c.1775N>A | p.Gly592Glu | p.G592E | Q8WUY3 | protein_coding | tolerated(1) | benign(0.018) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PRUNE2 | SNV | Missense_Mutation | novel | c.8824N>A | p.Leu2942Ile | p.L2942I | Q8WUY3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRUNE2 | SNV | Missense_Mutation | novel | c.5641N>G | p.Thr1881Ala | p.T1881A | Q8WUY3 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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