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Gene: POLR1C |
Gene summary for POLR1C |
Gene summary. |
Gene information | Species | Human | Gene symbol | POLR1C | Gene ID | 9533 |
Gene name | RNA polymerase I and III subunit C | |
Gene Alias | AC40 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O15160 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9533 | POLR1C | LZE2T | Human | Esophagus | ESCC | 2.45e-06 | 1.23e+00 | 0.082 |
9533 | POLR1C | LZE4T | Human | Esophagus | ESCC | 1.64e-10 | 1.42e-01 | 0.0811 |
9533 | POLR1C | LZE7T | Human | Esophagus | ESCC | 1.21e-05 | 2.82e-01 | 0.0667 |
9533 | POLR1C | LZE20T | Human | Esophagus | ESCC | 2.23e-06 | 1.51e-01 | 0.0662 |
9533 | POLR1C | LZE22T | Human | Esophagus | ESCC | 9.38e-05 | 3.23e-01 | 0.068 |
9533 | POLR1C | LZE24T | Human | Esophagus | ESCC | 2.34e-14 | 3.17e-01 | 0.0596 |
9533 | POLR1C | LZE21T | Human | Esophagus | ESCC | 1.89e-07 | 3.09e-01 | 0.0655 |
9533 | POLR1C | LZE6T | Human | Esophagus | ESCC | 4.80e-05 | 1.02e-01 | 0.0845 |
9533 | POLR1C | P1T-E | Human | Esophagus | ESCC | 5.04e-07 | 1.77e-01 | 0.0875 |
9533 | POLR1C | P2T-E | Human | Esophagus | ESCC | 1.13e-21 | 4.52e-01 | 0.1177 |
9533 | POLR1C | P4T-E | Human | Esophagus | ESCC | 1.27e-22 | 6.52e-01 | 0.1323 |
9533 | POLR1C | P5T-E | Human | Esophagus | ESCC | 2.76e-21 | 4.80e-01 | 0.1327 |
9533 | POLR1C | P8T-E | Human | Esophagus | ESCC | 3.52e-20 | 3.53e-01 | 0.0889 |
9533 | POLR1C | P9T-E | Human | Esophagus | ESCC | 1.15e-20 | 3.88e-01 | 0.1131 |
9533 | POLR1C | P10T-E | Human | Esophagus | ESCC | 1.51e-25 | 4.09e-01 | 0.116 |
9533 | POLR1C | P11T-E | Human | Esophagus | ESCC | 1.80e-10 | 1.24e-01 | 0.1426 |
9533 | POLR1C | P12T-E | Human | Esophagus | ESCC | 2.75e-14 | 3.59e-01 | 0.1122 |
9533 | POLR1C | P15T-E | Human | Esophagus | ESCC | 1.82e-22 | 2.96e-01 | 0.1149 |
9533 | POLR1C | P16T-E | Human | Esophagus | ESCC | 4.87e-25 | 4.81e-01 | 0.1153 |
9533 | POLR1C | P17T-E | Human | Esophagus | ESCC | 9.38e-11 | 3.71e-01 | 0.1278 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:0006360 | Liver | HCC | transcription by RNA polymerase I | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:0006383 | Liver | HCC | transcription by RNA polymerase III | 31/7958 | 46/18723 | 5.67e-04 | 3.61e-03 | 31 |
GO:00063832 | Oral cavity | OSCC | transcription by RNA polymerase III | 34/7305 | 46/18723 | 1.61e-06 | 2.11e-05 | 34 |
GO:00063601 | Oral cavity | OSCC | transcription by RNA polymerase I | 36/7305 | 55/18723 | 6.42e-05 | 5.22e-04 | 36 |
GO:00063831 | Oral cavity | LP | transcription by RNA polymerase III | 20/4623 | 46/18723 | 4.03e-03 | 2.61e-02 | 20 |
GO:00063603 | Skin | cSCC | transcription by RNA polymerase I | 30/4864 | 55/18723 | 6.13e-06 | 8.70e-05 | 30 |
GO:00063834 | Skin | cSCC | transcription by RNA polymerase III | 20/4864 | 46/18723 | 7.44e-03 | 3.50e-02 | 20 |
GO:00063604 | Thyroid | PTC | transcription by RNA polymerase I | 28/5968 | 55/18723 | 2.55e-03 | 1.31e-02 | 28 |
GO:00063835 | Thyroid | PTC | transcription by RNA polymerase III | 23/5968 | 46/18723 | 7.89e-03 | 3.33e-02 | 23 |
GO:000636011 | Thyroid | ATC | transcription by RNA polymerase I | 28/6293 | 55/18723 | 5.94e-03 | 2.39e-02 | 28 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046234 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0462311 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa03020 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa030201 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa04623 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa046231 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa046232 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
hsa046233 | Oral cavity | LP | Cytosolic DNA-sensing pathway | 31/2418 | 75/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 31 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR1C | SNV | Missense_Mutation | rs745593101 | c.68A>G | p.Asn23Ser | p.N23S | O15160 | protein_coding | tolerated(0.06) | benign(0.357) | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
POLR1C | SNV | Missense_Mutation | novel | c.20N>C | p.Val7Ala | p.V7A | O15160 | protein_coding | tolerated(0.16) | benign(0.039) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLR1C | insertion | Nonsense_Mutation | novel | c.521_522insTGTGCCGGGCCAGGAGGGGGTTTTTTAATCA | p.Trp175ValfsTer9 | p.W175Vfs*9 | O15160 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
POLR1C | SNV | Missense_Mutation | rs753326212 | c.359N>A | p.Arg120His | p.R120H | O15160 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
POLR1C | SNV | Missense_Mutation | rs777698504 | c.1004N>A | p.Arg335His | p.R335H | O15160 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-EK-A2R7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
POLR1C | SNV | Missense_Mutation | c.190N>C | p.Asp64His | p.D64H | O15160 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
POLR1C | SNV | Missense_Mutation | c.695N>T | p.Ser232Ile | p.S232I | O15160 | protein_coding | deleterious(0.02) | probably_damaging(0.969) | TCGA-Q1-A73R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
POLR1C | SNV | Missense_Mutation | c.640N>C | p.Cys214Arg | p.C214R | O15160 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR1C | SNV | Missense_Mutation | c.685N>A | p.Ala229Thr | p.A229T | O15160 | protein_coding | deleterious(0.02) | probably_damaging(0.955) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR1C | SNV | Missense_Mutation | novel | c.797N>T | p.Glu266Val | p.E266V | O15160 | protein_coding | tolerated(0.06) | benign(0.424) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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