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Gene: PHC3 |
Gene summary for PHC3 |
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Gene information | Species | Human | Gene symbol | PHC3 | Gene ID | 80012 |
Gene name | polyhomeotic homolog 3 | |
Gene Alias | EDR3 | |
Cytomap | 3q26.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4E2T1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80012 | PHC3 | CCI_1 | Human | Cervix | CC | 4.53e-02 | 5.15e-01 | 0.528 |
80012 | PHC3 | CCI_2 | Human | Cervix | CC | 2.60e-20 | 1.78e+00 | 0.5249 |
80012 | PHC3 | CCI_3 | Human | Cervix | CC | 1.83e-11 | 1.00e+00 | 0.516 |
80012 | PHC3 | sample3 | Human | Cervix | CC | 1.42e-02 | 7.04e-02 | 0.1387 |
80012 | PHC3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.73e-04 | -3.08e-01 | 0.0155 |
80012 | PHC3 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.20e-05 | 4.68e-01 | -0.1954 |
80012 | PHC3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.47e-03 | -1.48e-01 | 0.0338 |
80012 | PHC3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.97e-03 | -2.49e-01 | 0.0674 |
80012 | PHC3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.85e-03 | -5.52e-01 | 0.2585 |
80012 | PHC3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.76e-14 | -4.68e-01 | 0.3005 |
80012 | PHC3 | A001-C-207 | Human | Colorectum | FAP | 2.92e-03 | -3.00e-01 | 0.1278 |
80012 | PHC3 | A015-C-203 | Human | Colorectum | FAP | 3.49e-38 | -6.49e-01 | -0.1294 |
80012 | PHC3 | A015-C-204 | Human | Colorectum | FAP | 6.86e-11 | -5.17e-01 | -0.0228 |
80012 | PHC3 | A014-C-040 | Human | Colorectum | FAP | 3.16e-03 | -3.28e-01 | -0.1184 |
80012 | PHC3 | A002-C-201 | Human | Colorectum | FAP | 4.86e-15 | -4.80e-01 | 0.0324 |
80012 | PHC3 | A002-C-203 | Human | Colorectum | FAP | 1.54e-05 | -3.18e-01 | 0.2786 |
80012 | PHC3 | A001-C-119 | Human | Colorectum | FAP | 6.63e-07 | -4.71e-01 | -0.1557 |
80012 | PHC3 | A001-C-108 | Human | Colorectum | FAP | 2.15e-22 | -4.17e-01 | -0.0272 |
80012 | PHC3 | A002-C-205 | Human | Colorectum | FAP | 3.19e-25 | -6.15e-01 | -0.1236 |
80012 | PHC3 | A001-C-104 | Human | Colorectum | FAP | 4.88e-07 | -3.66e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHC3 | SNV | Missense_Mutation | c.638N>T | p.Ser213Leu | p.S213L | Q8NDX5 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHC3 | SNV | Missense_Mutation | c.720C>G | p.Ser240Arg | p.S240R | Q8NDX5 | protein_coding | deleterious(0.01) | possibly_damaging(0.696) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHC3 | SNV | Missense_Mutation | c.947C>G | p.Ser316Cys | p.S316C | Q8NDX5 | protein_coding | deleterious(0.02) | possibly_damaging(0.473) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
PHC3 | SNV | Missense_Mutation | rs780757485 | c.1045N>G | p.Ile349Val | p.I349V | Q8NDX5 | protein_coding | tolerated(0.12) | benign(0) | TCGA-D8-A1XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHC3 | SNV | Missense_Mutation | c.203G>A | p.Arg68Gln | p.R68Q | Q8NDX5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PHC3 | SNV | Missense_Mutation | rs368703405 | c.56N>T | p.Pro19Leu | p.P19L | Q8NDX5 | protein_coding | tolerated_low_confidence(0.08) | benign(0) | TCGA-EK-A2PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PHC3 | SNV | Missense_Mutation | novel | c.742N>G | p.Ser248Gly | p.S248G | Q8NDX5 | protein_coding | tolerated(0.14) | benign(0) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PHC3 | SNV | Missense_Mutation | c.1910N>A | p.Gly637Glu | p.G637E | Q8NDX5 | protein_coding | deleterious(0.03) | possibly_damaging(0.774) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHC3 | SNV | Missense_Mutation | c.1469N>A | p.Gly490Asp | p.G490D | Q8NDX5 | protein_coding | deleterious(0.01) | benign(0.158) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PHC3 | SNV | Missense_Mutation | c.2945C>T | p.Ala982Val | p.A982V | Q8NDX5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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