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Gene: PEX3 |
Gene summary for PEX3 |
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Gene information | Species | Human | Gene symbol | PEX3 | Gene ID | 8504 |
Gene name | peroxisomal biogenesis factor 3 | |
Gene Alias | PBD10A | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | P56589 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8504 | PEX3 | LZE4T | Human | Esophagus | ESCC | 4.13e-10 | 2.33e-01 | 0.0811 |
8504 | PEX3 | LZE7T | Human | Esophagus | ESCC | 2.13e-02 | 1.75e-01 | 0.0667 |
8504 | PEX3 | LZE24T | Human | Esophagus | ESCC | 8.25e-08 | 1.76e-01 | 0.0596 |
8504 | PEX3 | P1T-E | Human | Esophagus | ESCC | 8.81e-05 | 2.03e-01 | 0.0875 |
8504 | PEX3 | P2T-E | Human | Esophagus | ESCC | 8.65e-18 | 2.15e-01 | 0.1177 |
8504 | PEX3 | P4T-E | Human | Esophagus | ESCC | 2.39e-14 | 3.30e-01 | 0.1323 |
8504 | PEX3 | P5T-E | Human | Esophagus | ESCC | 2.57e-12 | 2.05e-01 | 0.1327 |
8504 | PEX3 | P8T-E | Human | Esophagus | ESCC | 2.02e-21 | 2.45e-01 | 0.0889 |
8504 | PEX3 | P9T-E | Human | Esophagus | ESCC | 2.11e-03 | 6.53e-02 | 0.1131 |
8504 | PEX3 | P10T-E | Human | Esophagus | ESCC | 1.90e-16 | 2.01e-01 | 0.116 |
8504 | PEX3 | P11T-E | Human | Esophagus | ESCC | 3.73e-07 | 2.09e-01 | 0.1426 |
8504 | PEX3 | P12T-E | Human | Esophagus | ESCC | 6.09e-12 | 1.48e-01 | 0.1122 |
8504 | PEX3 | P15T-E | Human | Esophagus | ESCC | 9.46e-17 | 3.59e-01 | 0.1149 |
8504 | PEX3 | P16T-E | Human | Esophagus | ESCC | 1.09e-17 | 3.13e-01 | 0.1153 |
8504 | PEX3 | P17T-E | Human | Esophagus | ESCC | 1.68e-07 | 2.28e-01 | 0.1278 |
8504 | PEX3 | P19T-E | Human | Esophagus | ESCC | 3.35e-02 | 3.19e-01 | 0.1662 |
8504 | PEX3 | P20T-E | Human | Esophagus | ESCC | 9.38e-13 | 2.34e-01 | 0.1124 |
8504 | PEX3 | P21T-E | Human | Esophagus | ESCC | 9.57e-22 | 5.20e-01 | 0.1617 |
8504 | PEX3 | P22T-E | Human | Esophagus | ESCC | 2.54e-08 | 1.21e-01 | 0.1236 |
8504 | PEX3 | P23T-E | Human | Esophagus | ESCC | 1.76e-12 | 3.69e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:00066124 | Esophagus | ESCC | protein targeting to membrane | 83/8552 | 131/18723 | 3.31e-05 | 2.73e-04 | 83 |
GO:00440918 | Esophagus | ESCC | membrane biogenesis | 38/8552 | 55/18723 | 3.78e-04 | 2.19e-03 | 38 |
GO:00066252 | Esophagus | ESCC | protein targeting to peroxisome | 14/8552 | 18/18723 | 5.77e-03 | 2.14e-02 | 14 |
GO:00726622 | Esophagus | ESCC | protein localization to peroxisome | 14/8552 | 18/18723 | 5.77e-03 | 2.14e-02 | 14 |
GO:00726632 | Esophagus | ESCC | establishment of protein localization to peroxisome | 14/8552 | 18/18723 | 5.77e-03 | 2.14e-02 | 14 |
GO:00435742 | Esophagus | ESCC | peroxisomal transport | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:007259418 | Oral cavity | OSCC | establishment of protein localization to organelle | 284/7305 | 422/18723 | 1.50e-32 | 1.35e-29 | 284 |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:001703815 | Oral cavity | OSCC | protein import | 136/7305 | 206/18723 | 3.15e-15 | 2.08e-13 | 136 |
GO:009015018 | Oral cavity | OSCC | establishment of protein localization to membrane | 163/7305 | 260/18723 | 7.13e-15 | 4.47e-13 | 163 |
GO:00066123 | Oral cavity | OSCC | protein targeting to membrane | 75/7305 | 131/18723 | 1.72e-05 | 1.69e-04 | 75 |
GO:00440917 | Oral cavity | OSCC | membrane biogenesis | 35/7305 | 55/18723 | 1.88e-04 | 1.27e-03 | 35 |
GO:0006625 | Oral cavity | OSCC | protein targeting to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0072662 | Oral cavity | OSCC | protein localization to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0072663 | Oral cavity | OSCC | establishment of protein localization to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0043574 | Oral cavity | OSCC | peroxisomal transport | 16/7305 | 22/18723 | 1.40e-03 | 6.79e-03 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414621 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0414631 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEX3 | SNV | Missense_Mutation | c.329N>C | p.Ile110Thr | p.I110T | P56589 | protein_coding | deleterious(0.01) | possibly_damaging(0.696) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PEX3 | SNV | Missense_Mutation | c.1036N>G | p.Gln346Glu | p.Q346E | P56589 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
PEX3 | SNV | Missense_Mutation | novel | c.601N>C | p.Ser201Pro | p.S201P | P56589 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PEX3 | SNV | Missense_Mutation | c.894N>A | p.Phe298Leu | p.F298L | P56589 | protein_coding | tolerated(0.13) | possibly_damaging(0.824) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PEX3 | SNV | Missense_Mutation | c.885N>T | p.Met295Ile | p.M295I | P56589 | protein_coding | tolerated(0.62) | benign(0.006) | TCGA-AG-4008-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PEX3 | SNV | Missense_Mutation | novel | c.158N>A | p.Arg53Gln | p.R53Q | P56589 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PEX3 | SNV | Missense_Mutation | rs866735953 | c.388N>T | p.Arg130Trp | p.R130W | P56589 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PEX3 | insertion | Frame_Shift_Ins | novel | c.181_182insCTATATTC | p.Asn61ThrfsTer10 | p.N61Tfs*10 | P56589 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PEX3 | insertion | Frame_Shift_Ins | novel | c.500_501insATCTGAAA | p.Ser167ArgfsTer13 | p.S167Rfs*13 | P56589 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PEX3 | SNV | Missense_Mutation | rs866735953 | c.388N>T | p.Arg130Trp | p.R130W | P56589 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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