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Gene: PDGFD |
Gene summary for PDGFD |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PDGFD | Gene ID | 80310 |
| Gene name | platelet derived growth factor D | |
| Gene Alias | IEGF | |
| Cytomap | 11q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9GZP0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 80310 | PDGFD | HTA12-18-3 | Human | Pancreas | PDAC | 3.00e-03 | 7.34e-01 | 0.0716 |
| 80310 | PDGFD | HTA12-9-2 | Human | Pancreas | PDAC | 2.06e-05 | 5.12e-01 | 0.0835 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Breast | Precancer |  |
| Breast | IDC |  |
| Breast | DCIS |  |
| Cervix | CC |  |
| Cervix | HSIL_HPV |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Breast | ADJ |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Breast | DCIS |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Breast | Healthy |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Cervix | ADJ |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Cervix | Precancer |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | AD |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | ADJ |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | CRC |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | FAP |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | MSI-H |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | SER |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Endometrium | ADJ |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Endometrium | AEH |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Endometrium | EEC |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Esophagus | ESCC |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | GC | ADJ |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | GC | GC |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | HNSCC | ADJ |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | HNSCC | OSCC |
| PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | HNSCC | Precancer |
| Page: 1 2 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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