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Gene: PDGFD |
Gene summary for PDGFD |
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Gene information | Species | Human | Gene symbol | PDGFD | Gene ID | 80310 |
Gene name | platelet derived growth factor D | |
Gene Alias | IEGF | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9GZP0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80310 | PDGFD | HTA12-18-3 | Human | Pancreas | PDAC | 3.00e-03 | 7.34e-01 | 0.0716 |
80310 | PDGFD | HTA12-9-2 | Human | Pancreas | PDAC | 2.06e-05 | 5.12e-01 | 0.0835 |
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Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Breast | ADJ |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Breast | DCIS |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Breast | Healthy |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Cervix | ADJ |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Cervix | Precancer |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | AD |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | ADJ |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | CRC |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | FAP |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | MSI-H |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | CRC | SER |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Endometrium | ADJ |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Endometrium | AEH |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Endometrium | EEC |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | Esophagus | ESCC |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | GC | ADJ |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | GC | GC |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | HNSCC | ADJ |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | HNSCC | OSCC |
PDGFD | PDGFRB | PDGFD_PDGFRB | PDGF | HNSCC | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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