![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NFYC |
Gene summary for NFYC |
![]() |
Gene information | Species | Human | Gene symbol | NFYC | Gene ID | 4802 |
Gene name | nuclear transcription factor Y subunit gamma | |
Gene Alias | CBF-C | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q13952 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4802 | NFYC | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.74e-04 | -3.27e-01 | 0.0155 |
4802 | NFYC | HTA11_866_3004761011 | Human | Colorectum | AD | 9.64e-04 | -2.47e-01 | 0.096 |
4802 | NFYC | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.62e-02 | -4.17e-01 | 0.2585 |
4802 | NFYC | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.20e-05 | -3.78e-01 | 0.3005 |
4802 | NFYC | A001-C-207 | Human | Colorectum | FAP | 1.40e-04 | -2.87e-01 | 0.1278 |
4802 | NFYC | A015-C-203 | Human | Colorectum | FAP | 5.40e-20 | -3.38e-01 | -0.1294 |
4802 | NFYC | A015-C-204 | Human | Colorectum | FAP | 5.03e-06 | -2.95e-01 | -0.0228 |
4802 | NFYC | A014-C-040 | Human | Colorectum | FAP | 2.47e-03 | -3.95e-01 | -0.1184 |
4802 | NFYC | A002-C-201 | Human | Colorectum | FAP | 2.08e-13 | -3.95e-01 | 0.0324 |
4802 | NFYC | A002-C-203 | Human | Colorectum | FAP | 3.49e-04 | -1.84e-01 | 0.2786 |
4802 | NFYC | A001-C-119 | Human | Colorectum | FAP | 1.84e-06 | -3.69e-01 | -0.1557 |
4802 | NFYC | A001-C-108 | Human | Colorectum | FAP | 3.44e-15 | -3.73e-01 | -0.0272 |
4802 | NFYC | A002-C-205 | Human | Colorectum | FAP | 1.06e-19 | -4.87e-01 | -0.1236 |
4802 | NFYC | A001-C-104 | Human | Colorectum | FAP | 7.37e-05 | -3.09e-01 | 0.0184 |
4802 | NFYC | A015-C-005 | Human | Colorectum | FAP | 1.27e-04 | -2.86e-01 | -0.0336 |
4802 | NFYC | A015-C-006 | Human | Colorectum | FAP | 2.36e-14 | -4.80e-01 | -0.0994 |
4802 | NFYC | A015-C-106 | Human | Colorectum | FAP | 4.92e-09 | -2.95e-01 | -0.0511 |
4802 | NFYC | A002-C-114 | Human | Colorectum | FAP | 9.10e-14 | -3.17e-01 | -0.1561 |
4802 | NFYC | A015-C-104 | Human | Colorectum | FAP | 1.78e-22 | -3.82e-01 | -0.1899 |
4802 | NFYC | A001-C-014 | Human | Colorectum | FAP | 6.03e-11 | -3.56e-01 | 0.0135 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:00064574 | Colorectum | FAP | protein folding | 44/2622 | 212/18723 | 4.36e-03 | 2.98e-02 | 44 |
GO:000645720 | Esophagus | HGIN | protein folding | 75/2587 | 212/18723 | 1.61e-15 | 3.86e-13 | 75 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:0006457111 | Skin | cSCC | protein folding | 131/4864 | 212/18723 | 2.96e-28 | 1.32e-25 | 131 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046122 | Colorectum | MSS | Antigen processing and presentation | 27/1875 | 78/8465 | 7.72e-03 | 2.91e-02 | 1.78e-02 | 27 |
hsa046123 | Colorectum | MSS | Antigen processing and presentation | 27/1875 | 78/8465 | 7.72e-03 | 2.91e-02 | 1.78e-02 | 27 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa0461230 | Esophagus | ESCC | Antigen processing and presentation | 51/4205 | 78/8465 | 3.57e-03 | 9.34e-03 | 4.78e-03 | 51 |
hsa0515212 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa04612114 | Esophagus | ESCC | Antigen processing and presentation | 51/4205 | 78/8465 | 3.57e-03 | 9.34e-03 | 4.78e-03 | 51 |
hsa0461214 | Liver | Cirrhotic | Antigen processing and presentation | 36/2530 | 78/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 36 |
hsa0461215 | Liver | Cirrhotic | Antigen processing and presentation | 36/2530 | 78/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 36 |
hsa051526 | Oral cavity | OSCC | Tuberculosis | 105/3704 | 180/8465 | 5.00e-05 | 2.04e-04 | 1.04e-04 | 105 |
hsa0461229 | Oral cavity | OSCC | Antigen processing and presentation | 47/3704 | 78/8465 | 2.37e-03 | 6.35e-03 | 3.23e-03 | 47 |
hsa0515211 | Oral cavity | OSCC | Tuberculosis | 105/3704 | 180/8465 | 5.00e-05 | 2.04e-04 | 1.04e-04 | 105 |
hsa04612113 | Oral cavity | OSCC | Antigen processing and presentation | 47/3704 | 78/8465 | 2.37e-03 | 6.35e-03 | 3.23e-03 | 47 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFYC | SNV | Missense_Mutation | c.169N>A | p.Asp57Asn | p.D57N | Q13952 | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.997) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
NFYC | SNV | Missense_Mutation | c.1214N>T | p.Pro405Leu | p.P405L | Q13952 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-D8-A1JD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NFYC | SNV | Missense_Mutation | rs200544060 | c.1348N>A | p.Gly450Arg | p.G450R | Q13952 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.515) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NFYC | deletion | Frame_Shift_Del | novel | c.1059delN | p.Ser356HisfsTer54 | p.S356Hfs*54 | Q13952 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
NFYC | SNV | Missense_Mutation | c.641N>G | p.Gln214Arg | p.Q214R | Q13952 | protein_coding | deleterious_low_confidence(0.01) | benign(0.107) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NFYC | SNV | Missense_Mutation | rs762151390 | c.1189N>A | p.Glu397Lys | p.E397K | Q13952 | protein_coding | deleterious_low_confidence(0.01) | benign(0.068) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
NFYC | SNV | Missense_Mutation | c.293G>T | p.Arg98Ile | p.R98I | Q13952 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NFYC | SNV | Missense_Mutation | rs762151390 | c.1189G>A | p.Glu397Lys | p.E397K | Q13952 | protein_coding | deleterious_low_confidence(0.01) | benign(0.068) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NFYC | SNV | Missense_Mutation | novel | c.634G>T | p.Ala212Ser | p.A212S | Q13952 | protein_coding | tolerated_low_confidence(0.16) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NFYC | SNV | Missense_Mutation | novel | c.860G>A | p.Arg287Gln | p.R287Q | Q13952 | protein_coding | tolerated_low_confidence(0.24) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |