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Gene: NDUFAF8 |
Gene summary for NDUFAF8 |
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Gene information | Species | Human | Gene symbol | NDUFAF8 | Gene ID | 284184 |
Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 8 | |
Gene Alias | C17orf89 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A1L188 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284184 | NDUFAF8 | GSM4909281 | Human | Breast | IDC | 6.15e-24 | 5.96e-01 | 0.21 |
284184 | NDUFAF8 | GSM4909282 | Human | Breast | IDC | 2.05e-03 | 2.57e-01 | -0.0288 |
284184 | NDUFAF8 | GSM4909285 | Human | Breast | IDC | 3.42e-08 | 2.33e-01 | 0.21 |
284184 | NDUFAF8 | GSM4909286 | Human | Breast | IDC | 3.40e-35 | 6.04e-01 | 0.1081 |
284184 | NDUFAF8 | GSM4909289 | Human | Breast | IDC | 2.37e-03 | 6.19e-01 | 0.1064 |
284184 | NDUFAF8 | GSM4909290 | Human | Breast | IDC | 9.76e-15 | 6.20e-01 | 0.2096 |
284184 | NDUFAF8 | GSM4909293 | Human | Breast | IDC | 1.60e-18 | 4.23e-01 | 0.1581 |
284184 | NDUFAF8 | GSM4909296 | Human | Breast | IDC | 1.18e-03 | -2.40e-01 | 0.1524 |
284184 | NDUFAF8 | GSM4909298 | Human | Breast | IDC | 5.62e-25 | 6.03e-01 | 0.1551 |
284184 | NDUFAF8 | GSM4909301 | Human | Breast | IDC | 7.79e-13 | 5.82e-01 | 0.1577 |
284184 | NDUFAF8 | GSM4909302 | Human | Breast | IDC | 1.36e-03 | 3.85e-01 | 0.1545 |
284184 | NDUFAF8 | GSM4909306 | Human | Breast | IDC | 2.38e-02 | 2.19e-01 | 0.1564 |
284184 | NDUFAF8 | GSM4909307 | Human | Breast | IDC | 2.95e-10 | 4.70e-01 | 0.1569 |
284184 | NDUFAF8 | GSM4909308 | Human | Breast | IDC | 1.70e-18 | 5.44e-01 | 0.158 |
284184 | NDUFAF8 | GSM4909311 | Human | Breast | IDC | 1.19e-11 | -3.51e-03 | 0.1534 |
284184 | NDUFAF8 | GSM4909317 | Human | Breast | IDC | 7.84e-03 | 2.40e-01 | 0.1355 |
284184 | NDUFAF8 | GSM4909319 | Human | Breast | IDC | 4.49e-28 | 2.40e-01 | 0.1563 |
284184 | NDUFAF8 | GSM4909320 | Human | Breast | IDC | 2.94e-19 | 8.37e-01 | 0.1575 |
284184 | NDUFAF8 | GSM4909321 | Human | Breast | IDC | 1.12e-08 | 3.46e-01 | 0.1559 |
284184 | NDUFAF8 | brca1 | Human | Breast | Precancer | 1.23e-14 | -3.30e-01 | -0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00102578 | Breast | Precancer | NADH dehydrogenase complex assembly | 19/1080 | 57/18723 | 1.93e-10 | 1.92e-08 | 19 |
GO:00329818 | Breast | Precancer | mitochondrial respiratory chain complex I assembly | 19/1080 | 57/18723 | 1.93e-10 | 1.92e-08 | 19 |
GO:00331088 | Breast | Precancer | mitochondrial respiratory chain complex assembly | 24/1080 | 93/18723 | 3.39e-10 | 3.16e-08 | 24 |
GO:001025713 | Breast | IDC | NADH dehydrogenase complex assembly | 22/1434 | 57/18723 | 6.20e-11 | 8.80e-09 | 22 |
GO:003298113 | Breast | IDC | mitochondrial respiratory chain complex I assembly | 22/1434 | 57/18723 | 6.20e-11 | 8.80e-09 | 22 |
GO:003310813 | Breast | IDC | mitochondrial respiratory chain complex assembly | 28/1434 | 93/18723 | 1.54e-10 | 1.83e-08 | 28 |
GO:001025723 | Breast | DCIS | NADH dehydrogenase complex assembly | 22/1390 | 57/18723 | 3.38e-11 | 5.17e-09 | 22 |
GO:003298123 | Breast | DCIS | mitochondrial respiratory chain complex I assembly | 22/1390 | 57/18723 | 3.38e-11 | 5.17e-09 | 22 |
GO:003310823 | Breast | DCIS | mitochondrial respiratory chain complex assembly | 28/1390 | 93/18723 | 7.50e-11 | 9.43e-09 | 28 |
GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
GO:001025720 | Esophagus | HGIN | NADH dehydrogenase complex assembly | 31/2587 | 57/18723 | 5.89e-13 | 8.62e-11 | 31 |
GO:003298120 | Esophagus | HGIN | mitochondrial respiratory chain complex I assembly | 31/2587 | 57/18723 | 5.89e-13 | 8.62e-11 | 31 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:001025712 | Liver | HCC | NADH dehydrogenase complex assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:003298112 | Liver | HCC | mitochondrial respiratory chain complex I assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:003310824 | Skin | cSCC | mitochondrial respiratory chain complex assembly | 64/4864 | 93/18723 | 5.48e-18 | 6.58e-16 | 64 |
GO:001025724 | Skin | cSCC | NADH dehydrogenase complex assembly | 42/4864 | 57/18723 | 6.46e-14 | 4.09e-12 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0471439 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714114 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471412 | Stomach | GC | Thermogenesis | 56/708 | 232/8465 | 1.35e-13 | 4.32e-12 | 3.04e-12 | 56 |
hsa0471413 | Stomach | GC | Thermogenesis | 56/708 | 232/8465 | 1.35e-13 | 4.32e-12 | 3.04e-12 | 56 |
hsa0471421 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
hsa0471431 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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