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Gene: NDUFAF7 |
Gene summary for NDUFAF7 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NDUFAF7 | Gene ID | 55471 |
Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 7 | |
Gene Alias | C2orf56 | |
Cytomap | 2p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q7L592 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55471 | NDUFAF7 | LZE4T | Human | Esophagus | ESCC | 2.45e-09 | 2.18e-01 | 0.0811 |
55471 | NDUFAF7 | LZE7T | Human | Esophagus | ESCC | 1.62e-04 | 2.17e-01 | 0.0667 |
55471 | NDUFAF7 | LZE8T | Human | Esophagus | ESCC | 1.10e-02 | 1.07e-01 | 0.067 |
55471 | NDUFAF7 | LZE20T | Human | Esophagus | ESCC | 7.90e-04 | 1.27e-01 | 0.0662 |
55471 | NDUFAF7 | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 2.93e-01 | 0.068 |
55471 | NDUFAF7 | LZE24T | Human | Esophagus | ESCC | 7.65e-05 | 1.42e-01 | 0.0596 |
55471 | NDUFAF7 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.39e-01 | 0.0655 |
55471 | NDUFAF7 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.50e-01 | 0.0875 |
55471 | NDUFAF7 | P2T-E | Human | Esophagus | ESCC | 2.92e-20 | 3.42e-01 | 0.1177 |
55471 | NDUFAF7 | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.27e-01 | 0.1323 |
55471 | NDUFAF7 | P5T-E | Human | Esophagus | ESCC | 4.36e-03 | 1.12e-01 | 0.1327 |
55471 | NDUFAF7 | P8T-E | Human | Esophagus | ESCC | 4.01e-10 | 1.56e-01 | 0.0889 |
55471 | NDUFAF7 | P9T-E | Human | Esophagus | ESCC | 3.82e-08 | 1.74e-01 | 0.1131 |
55471 | NDUFAF7 | P10T-E | Human | Esophagus | ESCC | 7.08e-12 | 2.21e-01 | 0.116 |
55471 | NDUFAF7 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.08e-01 | 0.1426 |
55471 | NDUFAF7 | P12T-E | Human | Esophagus | ESCC | 3.87e-15 | 2.59e-01 | 0.1122 |
55471 | NDUFAF7 | P15T-E | Human | Esophagus | ESCC | 2.65e-19 | 3.16e-01 | 0.1149 |
55471 | NDUFAF7 | P16T-E | Human | Esophagus | ESCC | 2.24e-10 | 2.54e-01 | 0.1153 |
55471 | NDUFAF7 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.31e-01 | 0.1662 |
55471 | NDUFAF7 | P20T-E | Human | Esophagus | ESCC | 1.04e-10 | 2.36e-01 | 0.1124 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:001025712 | Liver | HCC | NADH dehydrogenase complex assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:003298112 | Liver | HCC | mitochondrial respiratory chain complex I assembly | 50/7958 | 57/18723 | 1.50e-12 | 7.20e-11 | 50 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:00064792 | Liver | HCC | protein methylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00082132 | Liver | HCC | protein alkylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFAF7 | SNV | Missense_Mutation | novel | c.344N>A | p.Ser115Asn | p.S115N | Q7L592 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFAF7 | SNV | Missense_Mutation | novel | c.617C>T | p.Pro206Leu | p.P206L | Q7L592 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
NDUFAF7 | SNV | Missense_Mutation | c.5N>A | p.Ser2Asn | p.S2N | Q7L592 | protein_coding | tolerated_low_confidence(0.41) | benign(0) | TCGA-C8-A278-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
NDUFAF7 | insertion | Nonsense_Mutation | novel | c.616_617insTTTAAAAAATATA | p.Pro206LeufsTer2 | p.P206Lfs*2 | Q7L592 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
NDUFAF7 | SNV | Missense_Mutation | rs760279124 | c.1267C>T | p.Arg423Cys | p.R423C | Q7L592 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NDUFAF7 | SNV | Missense_Mutation | novel | c.651T>G | p.Phe217Leu | p.F217L | Q7L592 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFAF7 | SNV | Missense_Mutation | c.1187N>C | p.Lys396Thr | p.K396T | Q7L592 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
NDUFAF7 | SNV | Missense_Mutation | novel | c.958N>A | p.His320Asn | p.H320N | Q7L592 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NDUFAF7 | SNV | Missense_Mutation | novel | c.1124N>C | p.Lys375Thr | p.K375T | Q7L592 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NDUFAF7 | SNV | Missense_Mutation | c.1029N>T | p.Met343Ile | p.M343I | Q7L592 | protein_coding | tolerated(0.28) | benign(0.017) | TCGA-F4-6854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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