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Gene: MTERF3 |
Gene summary for MTERF3 |
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Gene information | Species | Human | Gene symbol | MTERF3 | Gene ID | 51001 |
Gene name | mitochondrial transcription termination factor 3 | |
Gene Alias | CGI-12 | |
Cytomap | 8q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | E5RIK9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51001 | MTERF3 | LZE2T | Human | Esophagus | ESCC | 1.94e-02 | 4.71e-01 | 0.082 |
51001 | MTERF3 | LZE4T | Human | Esophagus | ESCC | 5.46e-15 | 3.80e-01 | 0.0811 |
51001 | MTERF3 | LZE8T | Human | Esophagus | ESCC | 1.11e-06 | 2.94e-01 | 0.067 |
51001 | MTERF3 | LZE24T | Human | Esophagus | ESCC | 9.88e-13 | 3.60e-01 | 0.0596 |
51001 | MTERF3 | LZE6T | Human | Esophagus | ESCC | 1.05e-03 | 1.92e-01 | 0.0845 |
51001 | MTERF3 | P2T-E | Human | Esophagus | ESCC | 5.57e-18 | 3.91e-01 | 0.1177 |
51001 | MTERF3 | P4T-E | Human | Esophagus | ESCC | 1.93e-14 | 3.89e-01 | 0.1323 |
51001 | MTERF3 | P5T-E | Human | Esophagus | ESCC | 6.89e-24 | 4.39e-01 | 0.1327 |
51001 | MTERF3 | P8T-E | Human | Esophagus | ESCC | 3.84e-14 | 2.34e-01 | 0.0889 |
51001 | MTERF3 | P9T-E | Human | Esophagus | ESCC | 4.94e-17 | 4.52e-01 | 0.1131 |
51001 | MTERF3 | P10T-E | Human | Esophagus | ESCC | 9.38e-25 | 4.22e-01 | 0.116 |
51001 | MTERF3 | P11T-E | Human | Esophagus | ESCC | 1.26e-12 | 4.95e-01 | 0.1426 |
51001 | MTERF3 | P12T-E | Human | Esophagus | ESCC | 1.08e-29 | 5.73e-01 | 0.1122 |
51001 | MTERF3 | P15T-E | Human | Esophagus | ESCC | 1.04e-18 | 4.92e-01 | 0.1149 |
51001 | MTERF3 | P16T-E | Human | Esophagus | ESCC | 6.27e-34 | 6.00e-01 | 0.1153 |
51001 | MTERF3 | P19T-E | Human | Esophagus | ESCC | 7.03e-03 | 4.20e-01 | 0.1662 |
51001 | MTERF3 | P20T-E | Human | Esophagus | ESCC | 3.55e-11 | 2.81e-01 | 0.1124 |
51001 | MTERF3 | P21T-E | Human | Esophagus | ESCC | 1.25e-32 | 7.04e-01 | 0.1617 |
51001 | MTERF3 | P22T-E | Human | Esophagus | ESCC | 2.23e-23 | 4.74e-01 | 0.1236 |
51001 | MTERF3 | P23T-E | Human | Esophagus | ESCC | 1.12e-19 | 5.50e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0042255111 | Esophagus | ESCC | ribosome assembly | 50/8552 | 61/18723 | 5.66e-09 | 1.17e-07 | 50 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:004225522 | Liver | HCC | ribosome assembly | 50/7958 | 61/18723 | 2.79e-10 | 9.50e-09 | 50 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:004225520 | Oral cavity | OSCC | ribosome assembly | 49/7305 | 61/18723 | 4.73e-11 | 1.50e-09 | 49 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
GO:0042255110 | Oral cavity | LP | ribosome assembly | 44/4623 | 61/18723 | 8.20e-15 | 1.05e-12 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTERF3 | SNV | Missense_Mutation | novel | c.635A>C | p.Asn212Thr | p.N212T | Q96E29 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MTERF3 | insertion | Frame_Shift_Ins | novel | c.909_910insCCAACAATCA | p.Glu304ProfsTer8 | p.E304Pfs*8 | Q96E29 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MTERF3 | insertion | Frame_Shift_Ins | novel | c.871_872insCATCCTGGGCAACA | p.Leu291ProfsTer9 | p.L291Pfs*9 | Q96E29 | protein_coding | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
MTERF3 | SNV | Missense_Mutation | novel | c.770N>C | p.Arg257Thr | p.R257T | Q96E29 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A7UI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MTERF3 | SNV | Missense_Mutation | novel | c.808N>A | p.Glu270Lys | p.E270K | Q96E29 | protein_coding | tolerated(0.9) | benign(0) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MTERF3 | SNV | Missense_Mutation | c.893N>A | p.Met298Lys | p.M298K | Q96E29 | protein_coding | deleterious(0) | possibly_damaging(0.501) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTERF3 | SNV | Missense_Mutation | rs778548567 | c.931N>A | p.Glu311Lys | p.E311K | Q96E29 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MTERF3 | SNV | Missense_Mutation | novel | c.1105N>A | p.Leu369Ile | p.L369I | Q96E29 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTERF3 | SNV | Missense_Mutation | rs370527769 | c.1175C>A | p.Ser392Tyr | p.S392Y | Q96E29 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
MTERF3 | SNV | Missense_Mutation | c.314A>G | p.Asp105Gly | p.D105G | Q96E29 | protein_coding | tolerated(0.07) | benign(0.019) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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