![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MPG |
Gene summary for MPG |
![]() |
Gene information | Species | Human | Gene symbol | MPG | Gene ID | 4350 |
Gene name | N-methylpurine DNA glycosylase | |
Gene Alias | AAG | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P29372 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4350 | MPG | LZE2T | Human | Esophagus | ESCC | 3.67e-03 | 7.08e-01 | 0.082 |
4350 | MPG | LZE4T | Human | Esophagus | ESCC | 1.97e-12 | 5.08e-01 | 0.0811 |
4350 | MPG | LZE5T | Human | Esophagus | ESCC | 4.47e-05 | 1.40e-01 | 0.0514 |
4350 | MPG | LZE7T | Human | Esophagus | ESCC | 4.31e-06 | 5.40e-01 | 0.0667 |
4350 | MPG | LZE8T | Human | Esophagus | ESCC | 4.47e-05 | 2.76e-01 | 0.067 |
4350 | MPG | LZE20T | Human | Esophagus | ESCC | 5.28e-06 | 2.77e-01 | 0.0662 |
4350 | MPG | LZE22T | Human | Esophagus | ESCC | 3.61e-04 | 4.94e-01 | 0.068 |
4350 | MPG | LZE24T | Human | Esophagus | ESCC | 3.12e-21 | 8.62e-01 | 0.0596 |
4350 | MPG | LZE21T | Human | Esophagus | ESCC | 2.59e-04 | 4.35e-01 | 0.0655 |
4350 | MPG | LZE6T | Human | Esophagus | ESCC | 1.02e-03 | 3.45e-01 | 0.0845 |
4350 | MPG | P1T-E | Human | Esophagus | ESCC | 1.73e-16 | 8.83e-01 | 0.0875 |
4350 | MPG | P2T-E | Human | Esophagus | ESCC | 3.24e-55 | 1.06e+00 | 0.1177 |
4350 | MPG | P4T-E | Human | Esophagus | ESCC | 2.09e-16 | 5.33e-01 | 0.1323 |
4350 | MPG | P5T-E | Human | Esophagus | ESCC | 3.64e-41 | 9.67e-01 | 0.1327 |
4350 | MPG | P8T-E | Human | Esophagus | ESCC | 2.71e-51 | 9.26e-01 | 0.0889 |
4350 | MPG | P9T-E | Human | Esophagus | ESCC | 6.79e-27 | 6.97e-01 | 0.1131 |
4350 | MPG | P10T-E | Human | Esophagus | ESCC | 5.61e-47 | 1.00e+00 | 0.116 |
4350 | MPG | P11T-E | Human | Esophagus | ESCC | 3.97e-16 | 8.53e-01 | 0.1426 |
4350 | MPG | P12T-E | Human | Esophagus | ESCC | 4.33e-64 | 1.20e+00 | 0.1122 |
4350 | MPG | P15T-E | Human | Esophagus | ESCC | 4.36e-47 | 1.21e+00 | 0.1149 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062843 | Esophagus | ESCC | base-excision repair | 33/8552 | 43/18723 | 3.25e-05 | 2.69e-04 | 33 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:0006284 | Liver | HCC | base-excision repair | 27/7958 | 43/18723 | 5.79e-03 | 2.40e-02 | 27 |
GO:00062842 | Oral cavity | OSCC | base-excision repair | 28/7305 | 43/18723 | 4.71e-04 | 2.79e-03 | 28 |
GO:00062841 | Oral cavity | LP | base-excision repair | 19/4623 | 43/18723 | 4.04e-03 | 2.61e-02 | 19 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa034104 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa0341011 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa03410 | Oral cavity | OSCC | Base excision repair | 32/3704 | 44/8465 | 9.11e-05 | 3.25e-04 | 1.65e-04 | 32 |
hsa034101 | Oral cavity | OSCC | Base excision repair | 32/3704 | 44/8465 | 9.11e-05 | 3.25e-04 | 1.65e-04 | 32 |
hsa034102 | Oral cavity | LP | Base excision repair | 23/2418 | 44/8465 | 7.66e-04 | 3.75e-03 | 2.42e-03 | 23 |
hsa034103 | Oral cavity | LP | Base excision repair | 23/2418 | 44/8465 | 7.66e-04 | 3.75e-03 | 2.42e-03 | 23 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPG | SNV | Missense_Mutation | c.140G>C | p.Ser47Thr | p.S47T | P29372 | protein_coding | tolerated_low_confidence(0.07) | benign(0.005) | TCGA-AO-A1KR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
MPG | SNV | Missense_Mutation | rs2308313 | c.358N>T | p.Arg120Cys | p.R120C | P29372 | protein_coding | tolerated(0.06) | benign(0.391) | TCGA-S3-AA12-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
MPG | insertion | Frame_Shift_Ins | novel | c.433dupC | p.Arg145ProfsTer88 | p.R145Pfs*88 | P29372 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MPG | deletion | Frame_Shift_Del | novel | c.513delC | p.Ser172AlafsTer85 | p.S172Afs*85 | P29372 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
MPG | SNV | Missense_Mutation | novel | c.877G>A | p.Glu293Lys | p.E293K | P29372 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A952-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
MPG | insertion | Frame_Shift_Ins | novel | c.199_200insAC | p.Thr67AsnfsTer42 | p.T67Nfs*42 | P29372 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
MPG | SNV | Missense_Mutation | novel | c.640N>T | p.Leu214Phe | p.L214F | P29372 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MPG | SNV | Missense_Mutation | c.760C>T | p.Pro254Ser | p.P254S | P29372 | protein_coding | tolerated(0.85) | benign(0.014) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MPG | SNV | Missense_Mutation | c.299N>A | p.Arg100Gln | p.R100Q | P29372 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MPG | SNV | Missense_Mutation | c.736C>T | p.Arg246Cys | p.R246C | P29372 | protein_coding | tolerated(0.09) | benign(0.047) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |