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Gene: LINC01146 |
Gene summary for LINC01146 |
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Gene information | Species | Human | Gene symbol | LINC01146 | Gene ID | 283587 |
Gene name | long intergenic non-protein coding RNA 1146 | |
Gene Alias | LINC01146 | |
Cytomap | 14q31.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283587 | LINC01146 | NAFLD1 | Human | Liver | NAFLD | 4.76e-17 | 1.35e+00 | -0.04 |
283587 | LINC01146 | S41 | Human | Liver | Cirrhotic | 4.90e-04 | 7.67e-01 | -0.0343 |
283587 | LINC01146 | S43 | Human | Liver | Cirrhotic | 1.65e-04 | -2.89e-01 | -0.0187 |
283587 | LINC01146 | HCC1_Meng | Human | Liver | HCC | 2.31e-70 | -1.98e-01 | 0.0246 |
283587 | LINC01146 | HCC2_Meng | Human | Liver | HCC | 4.95e-09 | -3.43e-01 | 0.0107 |
283587 | LINC01146 | cirrhotic1 | Human | Liver | Cirrhotic | 9.29e-09 | -3.37e-01 | 0.0202 |
283587 | LINC01146 | cirrhotic2 | Human | Liver | Cirrhotic | 4.28e-09 | -3.37e-01 | 0.0201 |
283587 | LINC01146 | cirrhotic3 | Human | Liver | Cirrhotic | 3.02e-03 | -3.08e-01 | 0.0215 |
283587 | LINC01146 | HCC1 | Human | Liver | HCC | 1.96e-32 | 5.19e-01 | 0.5336 |
283587 | LINC01146 | Pt13.a | Human | Liver | HCC | 3.35e-08 | -3.31e-01 | 0.021 |
283587 | LINC01146 | Pt13.b | Human | Liver | HCC | 7.11e-04 | -3.33e-01 | 0.0251 |
283587 | LINC01146 | Pt14.d | Human | Liver | HCC | 1.43e-08 | -3.23e-01 | 0.0143 |
283587 | LINC01146 | S014 | Human | Liver | HCC | 8.68e-06 | -2.56e-01 | 0.2254 |
283587 | LINC01146 | S027 | Human | Liver | HCC | 2.91e-04 | -1.73e-01 | 0.2446 |
283587 | LINC01146 | S028 | Human | Liver | HCC | 6.85e-09 | 2.62e-02 | 0.2503 |
283587 | LINC01146 | S029 | Human | Liver | HCC | 1.45e-07 | 2.09e-01 | 0.2581 |
283587 | LINC01146 | HTA12-15-2 | Human | Pancreas | PDAC | 4.06e-02 | 1.95e-01 | 0.2315 |
283587 | LINC01146 | HTA12-23-1 | Human | Pancreas | PDAC | 8.83e-07 | 8.03e-01 | 0.3405 |
283587 | LINC01146 | HTA12-26-1 | Human | Pancreas | PDAC | 3.27e-24 | 9.66e-01 | 0.3728 |
283587 | LINC01146 | HTA12-29-1 | Human | Pancreas | PDAC | 7.36e-14 | 4.05e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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